Nazmul Haque Email and Phone Number
Nazmul Haque work email
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Nazmul Haque personal email
With over two decades of experience in RNA biology, innate immunology, and RNA virology, I bring a unique combination of skills in RNA drug discovery, RNA drug process development, and analytical assay development.In my current role, I specialize in RNA therapeutic development, synthesis and process development, and RNA characterization. Work closely with the translational research team for RNA-based drug discovery and assay development.Throughout my career, I have led multidisciplinary research teams, concentrating on RNA processing and innate immunology. My expertise lies in studying transcriptional and post-transcriptional RNA processes, including splicing, RNA stability regulation, translational regulation, RNA interference, DNA damage and integrated stress response. I am an effective collaborator, have demonstrated track record of impactful findings, and an engaging communicator for varied audiences. I thrive in collaborative environments that bring together diverse perspectives to address complex challenges.
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Associate Director Senior ScientistUltragenyxSouth San Francisco, Ca, Us
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Associate Director Senior Scientist & Research Lead (Rna Drug Discovery)Ultragenyx Mar 2023 - PresentNovato, California, Us• RNA-Based Drug Discovery: Led research to design and optimize RNA therapeutics for complex genetic disorders.• Focus Area: Rare genetic diseases linked to aberrant pre-mRNA splicing and dysregulated gene expression.• Analytical Assay Development: Developed assays and biomarkers for therapeutic stratification.• Therapeutic Platform Development: Developed assays to stratify RNA-based therapeutics and identify molecular targets.• Biologic Process Development: Led optimization of processes for biologic therapies.• mRNA Process Development: Applied enzyme kinetics and DoE methodologies to optimize mRNA synthesis and minimize immunogenicity.• Cross-Disciplinary Collaboration: Collaborated with translational research, analytical, and process development teams to advance biologic drug programs. -
Staff ScientistThe National Institutes Of Health 2014 - 2023Bethesda, Md, Us -
Postdoc FellowThe National Institutes Of Health Oct 2011 - Oct 2014Bethesda, Md, Us
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Postdoctoral Research AssociateStowers Institute For Medical Research 2008 - 2011Kansas City, Missouri, Us• Studied pre-mRNA splicing and Nonsense-Mediated mRNA Decay (NMD)• Discovered a novel regulatory mechanism of NMD elicitation in fruitfly Drosophila. • Discovered CWC22 as a novel factor of Exon Junction Complex (EJC)• Supervision of junior scientist and research collaborationBarbosa I, Haque N, Fiorini F, Barrandon C, Tomasetto C, Blanchette M and Le Hir H. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Nature Structure and Molecular Biology, (2012), 19: 983-990Saulière J* Haque N*, Harms S, Barbosa I, Blanchette M and Le Hir H. The exon junction complex differentially marks spliced junctions. Nature Structure and Molecular Biology, (2010), 17: 1269-1271. *Equal contribution -
Graduate Research And Teaching AssistantEhime University 2002 - 2008Ehime, Jp• Studied sequence-specific RNA degradation pathway (RNAi) and DNA methylation.• Studied epigenetic modification and positive strand RNA viral replication • Designed and constructed self-amplifying RNA virus, viral RNA preparation by in vitro transcription and host delivery• Managed lab, served as teaching assistant and trained junior laboratory membersHaque N, and Nishiguchi M. Bisulfite sequencing for analysis of cytosine-methylation in RNA silenced plants. Methods in Molecular Biology, (2011), 744: 187-197Haque AKMN, Yamaoka N. and Nishiguchi M. Spreading of RNA silencing along the transgene transcript is accompanied with DNA methylation. Breeding Sciences, (2010) 60: 361-370 Haque AKMN. and Nishiguchi M. RNA silencing and DNA methylation in plants. Book: RNA Interference Research Progress Nova publishers, (2008), ISBN: 978-1-60456-446-4 Haque AKMN,Yamaoka N. and Nishiguchi M. Cytosine methylation is associated with RNA silencing in silenced plants but not with systemic and transitive RNA silencing through grafting. Gene, (2007) 396:321-331Haque AKMN,Tanaka Y., Sonoda S. and Nishiguchi M. Analysis of RNA silencing after grafting in transgenic plants with the coat protein gene of Sweet potato feathery mottle virus. Plant Molecular Biology, (2007), 63:35-47
Nazmul Haque Skills
Nazmul Haque Education Details
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Stowers Institute For Medical ResearchMolecular Biology -
Ehime UniversityVirology
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Ehime UniversityVirology
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University Of DhakaBiochemistry And Molecular Biology
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University Of DhakaBiochemistry And Molecular Biology
Frequently Asked Questions about Nazmul Haque
What company does Nazmul Haque work for?
Nazmul Haque works for Ultragenyx
What is Nazmul Haque's role at the current company?
Nazmul Haque's current role is Associate Director Senior Scientist.
What is Nazmul Haque's email address?
Nazmul Haque's email address is na****@****nih.gov
What schools did Nazmul Haque attend?
Nazmul Haque attended Stowers Institute For Medical Research, Ehime University, Ehime University, University Of Dhaka, University Of Dhaka.
What skills is Nazmul Haque known for?
Nazmul Haque has skills like Molecular Cloning, Rna, Cell Biology, Qpcr, Dna Methylation, Protein Expression, Transfection, Confocal Microscopy, Immunoprecipitation, Genome Wide Rna Protein Interaction, Chromatin Immunoprecipitation, Bisulfite Genome Sequencing.
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