Nikolaos Biris

Nikolaos Biris Email and Phone Number

Senior Director, Structural and Functional Biology @ Astria Therapeutics, Inc.
Nikolaos Biris's Location
Boston, Massachusetts, United States, United States
Nikolaos Biris's Contact Details
About Nikolaos Biris

Structural biologist/Protein chemist with a biophysics background and a focus on hit discovery and lead optimization within multi-disciplinary teams. Extensive experience on the study of protein-ligand interactions and the structural and dynamic characterization of binding. Proficient in production and characterization of monoclonal and bispecific antibodies as well as antibody-drug conjugates.Expertise in managing cross-functional teams and designing all aspects of gene-to-structure workflows.Creative problem solving and troubleshooting applied to challenging projects in a start-up company environment using structural and biophysical methods.Demonstrated success in the use of multiple techniques:Mammalian cell culture, Protein chemistry, Protein purification, construct design, Biologics, fragment-based screening, structure-based drug design, NMR spectroscopy, Isothermal Titration Calorimetry (ITC), MicroScale Thermophoresis (MST), X-ray crystallography.

Nikolaos Biris's Current Company Details
Astria Therapeutics, Inc.

Astria Therapeutics, Inc.

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Senior Director, Structural and Functional Biology
Nikolaos Biris Work Experience Details
  • Astria Therapeutics, Inc.
    Senior Director, Structural And Functional Biology
    Astria Therapeutics, Inc. Feb 2024 - Present
    Boston, Ma, Us
  • Astria Therapeutics, Inc.
    Director, Assay Development
    Astria Therapeutics, Inc. Feb 2022 - Feb 2024
    Boston, Ma, Us
  • Brickbio, Inc.
    Director Of Protein Sciences
    Brickbio, Inc. Dec 2021 - Feb 2022
  • Brickbio, Inc.
    Scientific Project Leader
    Brickbio, Inc. Oct 2019 - Dec 2021
  • Harkerbio
    Principal Project Scientist
    Harkerbio Jul 2018 - Apr 2019
    Buffalo, New York, Us
  • Harkerbio
    Senior Research Scientist
    Harkerbio Mar 2017 - Jul 2018
    Buffalo, New York, Us
  • Albert Einstein College Of Medicine
    Research Associate
    Albert Einstein College Of Medicine Jun 2014 - Feb 2017
    Bronx, New York, Us
    My efforts focused on investigating protein-protein interactions related to signaling such as the mitochondrial cell death pathway. I explored protein interactions of the BAX protein to decode the mechanism of BAX translocation to the outer mitochondrial membrane (OMM). I also worked on the structure and targeting of proteins related to mitochondrial fusion and fission. For that purpose, I utilized advanced NMR techniques and experimentally driven computational methods coupled with biochemical and cell-based approaches. Moreover, I was involved in several drug discovery and development projects using my expertise in computer-aided screening, fragment-based screening, hit-to-lead design and optimization. For several protein targets, we have identified potent, selective, small molecule inhibitors and activators of signaling pathways with drug-like properties that are validated in animal disease models.
  • Ut Health Science Center
    Postdoctoral Fellow
    Ut Health Science Center Apr 2010 - Apr 2014
    San Antonio, Tx, Us
  • Rockefeller University
    Postdoctoral Fellow
    Rockefeller University Dec 2005 - Dec 2006
    New York, Ny, Us
  • Utrecht University
    Visiting Research Associate
    Utrecht University Aug 2005 - Nov 2005
    Utrecht, Utrecht, Nl
  • Rutgers University
    Postdoctoral Fellow
    Rutgers University Jan 2004 - Jun 2005
    New Brunswick, Nj, Us

Nikolaos Biris Skills

Protein Chemistry Protein Expression Protein Purification Biochemistry Structural Biology Life Sciences Molecular Biology Nmr Chemistry Biotechnology Mass Spectrometry Cell Cell Culture Pcr In Vivo Science Biophysics Molecular Cloning Fplc Drug Discovery X Ray Crystallography Fluorescence Spectroscopy Lc Ms Circular Dichroism Computational Biology Nmr Spectroscopy Drug Design Nmr Fragment Based Screening Cell Biology Nuclear Magnetic Resonance Research Drug Development Assay Development Gel Electrophoresis Purification Teamwork Communication Project Management

Nikolaos Biris Education Details

  • University Of Ioannina
    University Of Ioannina
    Peptide Chemistry
  • University Of Ioannina
    University Of Ioannina
    Chemistry

Frequently Asked Questions about Nikolaos Biris

What company does Nikolaos Biris work for?

Nikolaos Biris works for Astria Therapeutics, Inc.

What is Nikolaos Biris's role at the current company?

Nikolaos Biris's current role is Senior Director, Structural and Functional Biology.

What is Nikolaos Biris's email address?

Nikolaos Biris's email address is ni****@****bio.com

What is Nikolaos Biris's direct phone number?

Nikolaos Biris's direct phone number is +121059*****

What schools did Nikolaos Biris attend?

Nikolaos Biris attended University Of Ioannina, University Of Ioannina.

What skills is Nikolaos Biris known for?

Nikolaos Biris has skills like Protein Chemistry, Protein Expression, Protein Purification, Biochemistry, Structural Biology, Life Sciences, Molecular Biology, Nmr, Chemistry, Biotechnology, Mass Spectrometry, Cell.

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