Nikolaos Biris Email and Phone Number
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Structural biologist/Protein chemist with a biophysics background and a focus on hit discovery and lead optimization within multi-disciplinary teams. Extensive experience on the study of protein-ligand interactions and the structural and dynamic characterization of binding. Proficient in production and characterization of monoclonal and bispecific antibodies as well as antibody-drug conjugates.Expertise in managing cross-functional teams and designing all aspects of gene-to-structure workflows.Creative problem solving and troubleshooting applied to challenging projects in a start-up company environment using structural and biophysical methods.Demonstrated success in the use of multiple techniques:Mammalian cell culture, Protein chemistry, Protein purification, construct design, Biologics, fragment-based screening, structure-based drug design, NMR spectroscopy, Isothermal Titration Calorimetry (ITC), MicroScale Thermophoresis (MST), X-ray crystallography.
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Senior Director, Structural And Functional BiologyAstria Therapeutics, Inc. Feb 2024 - PresentBoston, Ma, Us -
Director, Assay DevelopmentAstria Therapeutics, Inc. Feb 2022 - Feb 2024Boston, Ma, Us -
Director Of Protein SciencesBrickbio, Inc. Dec 2021 - Feb 2022 -
Scientific Project LeaderBrickbio, Inc. Oct 2019 - Dec 2021 -
Principal Project ScientistHarkerbio Jul 2018 - Apr 2019Buffalo, New York, Us -
Senior Research ScientistHarkerbio Mar 2017 - Jul 2018Buffalo, New York, Us -
Research AssociateAlbert Einstein College Of Medicine Jun 2014 - Feb 2017Bronx, New York, UsMy efforts focused on investigating protein-protein interactions related to signaling such as the mitochondrial cell death pathway. I explored protein interactions of the BAX protein to decode the mechanism of BAX translocation to the outer mitochondrial membrane (OMM). I also worked on the structure and targeting of proteins related to mitochondrial fusion and fission. For that purpose, I utilized advanced NMR techniques and experimentally driven computational methods coupled with biochemical and cell-based approaches. Moreover, I was involved in several drug discovery and development projects using my expertise in computer-aided screening, fragment-based screening, hit-to-lead design and optimization. For several protein targets, we have identified potent, selective, small molecule inhibitors and activators of signaling pathways with drug-like properties that are validated in animal disease models. -
Postdoctoral FellowUt Health Science Center Apr 2010 - Apr 2014San Antonio, Tx, Us -
Postdoctoral FellowRockefeller University Dec 2005 - Dec 2006New York, Ny, Us -
Visiting Research AssociateUtrecht University Aug 2005 - Nov 2005Utrecht, Utrecht, Nl -
Postdoctoral FellowRutgers University Jan 2004 - Jun 2005New Brunswick, Nj, Us
Nikolaos Biris Skills
Nikolaos Biris Education Details
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University Of IoanninaPeptide Chemistry -
University Of IoanninaChemistry
Frequently Asked Questions about Nikolaos Biris
What company does Nikolaos Biris work for?
Nikolaos Biris works for Astria Therapeutics, Inc.
What is Nikolaos Biris's role at the current company?
Nikolaos Biris's current role is Senior Director, Structural and Functional Biology.
What is Nikolaos Biris's email address?
Nikolaos Biris's email address is ni****@****bio.com
What is Nikolaos Biris's direct phone number?
Nikolaos Biris's direct phone number is +121059*****
What schools did Nikolaos Biris attend?
Nikolaos Biris attended University Of Ioannina, University Of Ioannina.
What skills is Nikolaos Biris known for?
Nikolaos Biris has skills like Protein Chemistry, Protein Expression, Protein Purification, Biochemistry, Structural Biology, Life Sciences, Molecular Biology, Nmr, Chemistry, Biotechnology, Mass Spectrometry, Cell.
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