Andrew Nelson Email & Phone Number

Philadelphia, Pennsylvania, United States

Engineering novel AAV capsids for treatment of neurological disorders

Philadelphia, Pennsylvania

• Studied molecular mechanisms of amyotrophic lateral sclerosis (ALS) using patient-derived neurons and transgenic mouse models, leading to several peer-reviewed publications
• Presented findings at national and international conferences, including the Society for Neuroscience Annual Meeting and the Packard Center for ALS Research Symposium

Phoenix, Arizona

• Employed lentiviral vectors to reprogram human fibroblasts into induced neurons (iNeurons) as an experimental platform for the laboratory
• Identified dendritic arborization deficits in frontotemporal dementia (FTD) patient-derived iNeurons and in the brain of a transgenic FTD mouse models
• Co-authored a review article describing the advantages and disadvantages of patient-derived in vitro systems in the modeling of neurodegenerative disease

Baltimore, Maryland

• Learned and became proficient in cell and molecular biology techniques including mammalian cell culture, qPCR, western blot, and DNA/RNA extraction
• Examined the role of pathological protein accumulation in neurodegenerative disease using patient-derived lymphocytes and fibroblasts
• Presented research findings at end-of-summer symposium

Doctor Of Philosophy - Phd, Neuroscience

Mentor: Davide Trotti, PhD Thesis title: “Determining the Role of Glucose Hypometabolism as a Modifier of C9orf72-ALS/FTD: Potential.

Bachelor Of Science - Bs, Biotechnology