Nicholas B. Vera Email and Phone Number
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Nicholas B. Vera personal email
I have 23 years of experience in small and large molecule mass spectrometry, 20 of which have been with pharmaceutical companies focused on cardiovascular and metabolic disease. Applications include: ADME, PK/PD, metabolite ID, oligonucleotide analysis, siRNA, RNAi, biomarker discovery, LC-MS and LC-MS/MS, GC-MS, DMS-MS/MS, lipidomics, metabolomics, QC, and high throughput screening. Specialties include small and large molecule analytics, principally the application of mass spectrometry. Experience in both biotech and pharmaceutical companies.Specialties: Mass spectrometry (QQQ, ion trap, Q-TOF, Orbitrap)High resolution accurate mass (HRAM) mass spectrometryDifferential mobility spectrometry-tandem mass spectrometry (DMS-MS/MS)Ion mobilityUPLC separation (Waters)HPLC separation (Waters, Agilent, Shimadzu)Reversed-phaseReversed-phase ion pairing chromatographyHILICNormal phase chromatographyLC-MS (Waters) LC-MS/MS (Waters, Sciex, Thermo)GC-MS (Agilent)GC-MS/MS (Agilent, Waters)Triversa Nanomate (Advion)High throughput robotic equipment (Tecan, Multi-mek, Bio-Mek)Metabolite IDsiRNARNAiBiomarker discoveryPK/PDADMEPurification and characterization of small molecules
Novo Nordisk
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Senior Scientist, Oligonucleotide Bioanalysis, Early Development, Global Nucleic Acid TherapiesNovo Nordisk Dec 2023 - PresentBagsværd, DkMember of the Nonclinical Pharmacology group, within Early Development, of the Global Nucleic Acid Therapies (GNAT) department, performing HPLC-FD based PK analysis of siRNA therapeutics. Currently supporting programs entering the clinic. Performed bioanalysis method development and method qualification of oligonucleotide test articles in various matrices (e.g. plasma, liver, urine) from various animal models (e.g. mouse, NHP). Utilized Phoenix WinNonlin software to process and reduce PK data (e.g. non-compartmental analysis). Currently developing LC-MS/MS based methods for PK applications. Performed QC of bioanalytical data generated from nonclinical PK/PD studies used to inform and support programs entering the clinic. Authored bioanalysis reports from nonclinical PK/PD studies that were incorporated into IND filing submissions. Hired and mentored 1 summer intern in the area of liquid chromatography and mass spectrometry. Hired and currently managing 1 contract employee in the areas of PK and bioanalysis.
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Scientist Ii, Oligonucleotide Bioanalysis, Early Development, Global Nucleic Acid TherapiesNovo Nordisk Mar 2023 - Dec 2023Bagsværd, Dk
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Scientist Ii, Dmpk Oligonucleotide BioanalysisDicerna Pharmaceuticals Inc., A Novo Nordisk Company 2021 - Mar 2023Member of the Bioanalytical Chemistry group within the Chemistry department. Utilizing reversed phase ion-pairing chromatography coupled to high resolution accurate mass (HRAM) mass spectrometry for metabolite ID profiling of oligonucleotide therapeutics. Developed and qualified an LC-MS based immunoprecipitation assay for PK applications. Performing sample preparation from various matrices (e.g. plasma, urine, liver, adipose, muscle). Developing targeted and untargeted LC-MS/MS methods for oligonucleotide quantitation. Optimizing oligonucleotide data reduction workflows (e.g. Thermo BioPharma Finder, ProMass). Currently supporting siRNA discovery and pre-clinical programs.
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Senior ScientistPfizer 2014 - 2020New York, New York, UsMember of the Internal Medicine Research Unit (IMRU). Utilized targeted and non-targeted mass spectrometry approaches for lipid and metabolic profiling. Performed pre-clinical biomarker discovery experiments that led to the development of pharmacodynamic assays. Performed metabolic tracer studies to determine the enrichment of stable isotopes in various lipid species and other small molecule metabolites. Research programs focused on Type II Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), Alzheimer’s Disease and Parkinson’s Disease. -
ScientistPfizer 2011 - 2014New York, New York, UsDescribe your position
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Scientist 1Novartis 2010 - 2011Basel, Baselstadt, ChMember of the Analytical Biochemistry group within the Cardiovascular and Metabolic Diseases department, performing LC/MS, LC/MS/MS, GC/MS, and GC/MS/MS analysis of biological samples. Research programs focused on targets associated with type II diabetes and obesity.• High quality method development for lipidomicso Developed methods for lipid extraction from different matrices (plasma/serum, liver, muscle, urine, and feces)o Tissue pulverization and homogenization for high quality lipid extractiono LC-MS MRM, neutral loss scan, and precursor ion scan profiling for targeting lipidso Co-developed excel macros for fast and accurate data processing• Generated lipid profiles for studying type II diabetes and obesity• Implemented new instrument technologies for lipidomics biomarker discovery• Performed various derivatization experiments (fatty acid methyl esters, pentafluorobenzyl esters)• Collaborated with Pharmacology and Biochemistry groups within the Cardiovascular and Metabolic Diseases, Oncology, Dermatology, and Neurodisease departments• Participated in experimental design, generated study plans and reports for each project, and presented results to the appropriate project team(s) -
Scientific Associate IiNovartis 2006 - 2010Basel, Baselstadt, Ch
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Scientific Associate INovartis 2004 - 2006Basel, Baselstadt, Ch
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Associate ScientistArqule 2001 - 2004Member of the rheumatoid arthritis drug discovery group performing LC/MS and LC/MS/MS analysis of samples. Achievements included moving one chemical series from lead generation to pre-clinical toxicology studies in less than one year. A second distinct chemical series moved from lead generation through lead optimization to in vivo efficacy studies in less than nine months.- Performed QC on combinatorial compounds in the bioanalytical chemistry group using HPLC/UV/ELSD/MS and performed instrument maintenance and calibration- Determined eADME parameters for organic compounds entering in vitro studies, performed data acquisition and assessment, recorded LC/MS methods and results, tabulated data and reported results- Developed and validated an assay to assess aqueous sample solubility for up to three different pHs using liquid chromatography/mass spectrometry and UV absorption- Trained medicinal chemists in the use of an open access mass spectrometer- Presented data and conclusions at department meetings
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InternMillennium: The Takeda Oncology Company 2000 - 2000
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InternBiomerieux 1998 - 1998Marcy-L'Étoile, Auvergne-Rhône-Alpes, Fr
Nicholas B. Vera Skills
Nicholas B. Vera Education Details
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Northeastern UniversityChemistry -
Northeastern UniversityChemistry
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Boston UniversityBiochemistry And Molecular Biology
Frequently Asked Questions about Nicholas B. Vera
What company does Nicholas B. Vera work for?
Nicholas B. Vera works for Novo Nordisk
What is Nicholas B. Vera's role at the current company?
Nicholas B. Vera's current role is Senior Scientist, Oligonucleotide Bioanalysis, Early Development, Global Nucleic Acid Therapies, Novo Nordisk.
What is Nicholas B. Vera's email address?
Nicholas B. Vera's email address is ni****@****zer.com
What schools did Nicholas B. Vera attend?
Nicholas B. Vera attended Northeastern University, Northeastern University, Boston University.
What skills is Nicholas B. Vera known for?
Nicholas B. Vera has skills like Lc Ms, Hplc, Mass Spectrometry, Biotechnology, Assay Development, Purification, Drug Discovery, Biochemistry, Chromatography, In Vitro, High Throughput Screening, Chemistry.
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