Nicholas Spadoni Email & Phone Number

Hayward, California, United States

• Supported development of cutting-edge antibody therapeutics as a member of a fast-paced, interdisciplinary team focused on delivering quality data for clients.• Spearheaded internal R&D initiatives, notably driving the creation and evaluation of an innovative, targeted AAV gene therapy delivery platform.• Independently formulated and optimized assay protocols, enhancing efficiency in method execution, with thorough documentation allowing for smooth implementation.• Engaged in effective client communication, both written and verbal, to articulate and disseminate pertinent scientific findings.• Took initiative to address unique challenges around the workplace, not typical to traditional scientific duties, including equipment maintenance, repair, and facility handiwork.

Hayward, California, United States

• Performed in vitro ADME screening and profiling of compounds to bolster pre-clinical drug and therapeutic exploration for biotech, pharmaceutical, and academic entities.• Collaborated within an interdisciplinary setting to execute diverse bioanalytical methodologies, encompassing ELISA, flow cytometry, LC/MS and HPLC.• Interfaced with clients, effectively communicating findings, and accommodating evolving research objectives.

Concord, California, United States

- Data handling and quality control (QC) analyst for clinical and GLP raw data, Excel data management files, and FDA submission reports- Processing of blood products for performance validation studies in a GLP setting- Measuring human blood components for key physiological parameters including pH,osmolality, protein content, and coagulation function

Berkeley, Ca

-Performing stem cell tissue culture based experiments to aid in development of a proprietary non-invasive tracking method for transplanted cells in vivo in a fast-paced, start-up environment-Streamlined data processing and presentation of fluorescent microscope images and various plate based assay data-Assisting in operation of Terumo Quantum Cell Expansion system for production of in-house stem cell bank-General laboratory duties including cleaning, supply inventory and ordering, vendor management, and equipment maintenance

Berkeley, Ca

-Researching and analyzing chemicals that inactivate virus for the purification of protein therapeutics in the manufacturing process. Patent and publication pending.-Assisting in the development and validation of viral clearance methods for Phase I, II, and III protein therapeutics in a GLP study environment-Responsible for general laboratory practices including: data presentation, report drafting, assay validation, cell culture maintenance of multiple cell lines, laboratory cleaning, and equipment maintenance-Miscellaneous: Mentoring college summer interns, training new employees, and interviewing prospective job candidates

Chico, California Area

-Assay troubleshooting and development-Protocol development-Mammalian cell line tissue culture-Molecular techniques including: DNA and protein gel electrophoresis, western blot, nucleic acid extraction, nuclear content extract, PCR amplification, densitometry-Preparation of media and reagent-General lab housekeeping and maintenance -Produce technical documents-Present data/findings written and orally