Nicholas Boria Email & Phone Number

Phoenix, Az, Us

Phoenix, Az, Us

Phoenix, Arizona, United States

Next-Generation Sequencing (NGS): Caris has one of the most advanced sequencing laboratories in the world, enabling Whole Exome (DNA) and Whole Transcriptome (RNA) sequencing on every patient.DNA Sequencing: Whole Exome DNA sequencing is performed on all tumor types and for every patient, enabling accurate detection of mutations, copy number variations, insertions and deletions in a large number of cancer-relevant genes, plus precisely characterize homologous recombination deficiency* (HRD), genome-wide loss of heterozygosity (LOH), microsatellite instability (MSI), tumor mutational burden (TMB) and human leukocyte antigen (HLA) genotyping*.RNA Sequencing: Whole Transcriptome RNA Sequencing analysis is performed on every patient and is the superior method to detect clinically relevant aberrations such as gene-fusion events and splice variants. RNA provides sequence information after gene splicing has occurred, thus avoiding the complexities of genomic features of DNA, such as large intronic regions. Caris molecular profiling has the ability to detect rare fusion events far better than DNA-based short-read methods, and provides broad coverage of all exons, capturing all possible fusion partners.Immunohistochemistry (IHC): Caris evaluates protein biomarkers through an extensive immunohistochemical panel analyzed in a tumor-type specific manner to conserve tissue and avoid unnecessary testing. Our large team of board-certified expert pathologists utilizes digital pathology, overseeing application and interpretation of this technology.In situ Hybridization (ISH): For select genes, we offer ISH to provide higher level of resolution to our IHC results to detect amplification.Pyrosequencing (PyroSeq): We offer methylation analysis of the MGMT promoter to guide therapy selection in glioma.

Phoenix, Arizona, United States

The Ivy Brain Tumor Center is home to the largest Phase 0 clinical trials program in the world and the first of its kind for neuro-oncology. We have adapted the Phase 0 strategy to brain tumor patients and incorporated a clinical trial ‘trigger’ that advances Phase 0 patients into a therapeutic study arm only if the drug is having an effect in an individual patient.This approach addresses the two most common reasons most drugs fail in brain tumor patients:Most new drugs are incapable of reaching the brain.Laboratory animal studies of new drugs paint an incomplete picture of how the drugs will perform in humans.In a conventional Phase 1, 2, or 3 clinical trials, a patient may be on an experimental drug for months before learning that the therapy is ineffective. At the Ivy Center, we understand that time is the most important commodity for our patients. Therefore, our Phase 0 clinical trials match patients to first-in-class drug combinations, confirm drug effects within days of exposure, and only treat patients when therapies are active in a patient’s own tumor.

Phoenix, Arizona, United States

My Responsibilities and Experiences: Created 2nd generation Lentiviral vectors such as TDT, to transduce patient derived glioblastoma cells Conducted mouse health assessments on patient derived xenograph models to assess for experimental collection Maintained mammalian cell lines (U87, BT145, GB189) for DNA, RNA, and protein isolation Grew cells lines for luciferization which were used for intracranial injections to develop patient derived xenograph mouse models Conducted perfusions, brain extractions, blood collections, and intracranial injections on PDX mice Organized and maintained a constant supply of numerous medias and buffers for the entire lab to use during experiments Worked collaboratively with OR nurses and pharmacodynamics lab technicians to establish a smooth and timely method for crucial patient tissue collections

Tucson, Arizona, United States

Customer Service:• Provide a positive representation of [EMPLOYER].• Proactively assist customers in solving problems.• Greet customers entering and throughout the store. Thank customers when finished and when they are leaving the store.• Possess a friendly outgoing demeanor; work well with customers as well as associates.• Ensure all pages and calls are answered promptly, courteously and effectively.• Forward any customer complaint that cannot be handled to a member of management.• Possess strong product knowledge and knowledge of store layout and location of products.• Assist customers throughout the store with personal, customized service based on the premise of amazing every customer, every time.Store Operations• Assist in creating a positive, professional and safe work environment.• Assist with receiving, checking in and stocking of merchandise throughout the store.• Assist with maintaining back stock levels.• Assist with daily maintenance, orderliness and cleanliness of the sales floor, stock room and outdoor merchandise area.• Assist with providing a clean and orderly sales floor, including end caps and ad merchandise.• Assist with merchandise resets through the store.• Provide assistance to Department Specialists, i.e. price changes, special orders.• Ensure signage is current throughout the store.• Operate forklift with proper training.• Communicate any Store Support Center issue to General Manager for follow up.• Communicate any merchandising, cost control or sales idea to General Manager.• Participate in store meetings.• Be professional in appearance and actions.• Perform all other duties as assigned.

Tucson, Arizona Area

Phoenix, Arizona Area

Paradise Valley High School

I was elected to be the treasurer for the organization, keeping records of purchase orders, club fees, fundraising, and more. This position holds a great amount of responsibility since being a unified organization rests on looking the same with t-shirts, which the treasurer is responsible for.1) Is responsible for all financial dealings with NHS. 2) Records all financial transactions. 3) Records and collects membership dues. 4) Provides financial report to executive board and general meeting as needed. 5) Provides annual financial report to principal and membership. 6) Works directly with and is answerable to NHS advisors. 7) Assumes all duties and responsibilities that may occur during the year.

Tempe, Arizona

The goal of our research is to identify novel pharmacological and behavioral interventions for the treatment of drug abuse, and to explore the neurobiological substrates of addiction. Our work has revealed novel neurobiological mechanisms of nicotine addiction, and has the potential to contribute to the development of novel therapeutic options aimed at reversing nicotine-induced alterations and thus improve smoking cessation outcomes. This work has resulted in translational collaborations to examine clinical efficacy of pharmacotherapeutics in promoting smoking cessation.The lab examines the neurobiological underpinnings of cue-triggered motivation and conditioned reinforcement, specifically examining alterations in synaptic plasticity via dendritic spine morphology and glutamatergic signaling in nicotine self-administration and reinstatement. This research utilizes both in vivoand in vitro methodologies to study rapid alterations in synaptic plasticity (measured as changes in dendritic spines or AMPA/NMDA ratios) during or immediately following behavior (specifically, during reinstatement of cocaine or nicotine seeking).

Tucson, Arizona Area

I researched different protein mechanisms, structures, and properties. In addition, I aided in discovering new ion channel pathways that may be used to relieve chronic pain.

Phoenix, Arizona Area

This manager/representative took control over who was allowed to use the technology in the classroom, manage inventory of computers, and assist for someone in need when dealing with technology.

Neuroscience And Cognitive Science, Neurobiology And Neurosciences

All students have: a science foundation in biology, chemistry and physics; a psychology/philosophy foundation focusing on the mind.

Biotechnician Assistant Credential (Bace), Biology Technician/Biotechnology Laboratory Technician

This school is a small specialty school apart of Paradise Valley High School but stands alone in its curriculum due to the coursework.

High School, Biotechnology, 12Th

Activities and Societies: Link Crew, National Honors Society (NHS), HOSA (Health Occupations Students of America), Concert BandI have.

Physical Sciences, 10Th

Activities and Societies: Concert Band, Marching BandI was educated on the basics of core classes such as English, Math, Science.