Nicholas Delatorre Email & Phone Number

Boston, Ma, Us

Boston, Massachusetts, United States

• Built workflows in Asana for project and resource tracking aligned with the modality lead to ensure timelines were met• CHO cell culture development lead using BDCU 2L, Ambr250 HT, and Ambr15 to develop the initial media and process • Performed DOEs involving media optimization, additives, and process levers to build a toolbox of product quality and titer modulating factors• Presented CHO work at Cell UK titled: “The CHO Edge System: Advanced process development to tune product quality” https://www.youtube.com/watch?v=Mqq_yo0g8bc• Led over 5 tech transfer projects involving process transfer to both innovator partners and CDMOs successfully demonstrating process validation• Developed initial lentiviral process and optimization in Ambr15 with further mentorship of PD scientists for both Lentiviral and AAV small scale optimization• Managed the procurement and development of initial downstream and analytical capabilities including feasibility analysis of bioreactor systems, Bio Accord LCMS, HPLC, Octet, and StreamLink purification system• Managed 3 direct reports of varying skillsets from Co-op, Contractor, and Full-Time

Boston, Massachusetts, United States

Boston, Massachusetts, United States

Cambridge, Massachusetts, United States

• Established novel alternative host bioreactor processes and achieved initial target goals for cell density• Successfully lobbied for an internal grant and negotiated with vendors and internal stakeholders to establish laboratory infrastructure for innovation projects• Improved upstream/downstream continuous manufacturing process in small scale to develop the next generation of bioprocessing• Authored and supported clinical documentation and reports to produce monoclonal antibodies while simultaneously developing the small-scale process for eventual tech transfer

Greater Boston Area

• Led the formulation and process development of polymeric biodegradable materials to tune the degradation rate for desired properties and increase the retention of an ultra-long lasting oral dosage form in the gastric environment• Created protocols to understand material properties in different simulated environments using Thermal (DSC, TGA, Rheology) and Mechanical Characterization (Instron, Flexural Testing) for pH responsive and biodegradable materials• Continuous improvement of cryogenic grinding process to increase yield by 30% and decrease runtime by 50%• Planning, execution, and analysis of polymer formulations from benchtop hot melt extrusion to large scale continuous manufacturing • Authored and executed process equipment Batch Records and SOPs for cGMP regulatory manufacturing of polymer formulations to ensure product quality• Created and optimized 3D printing filament for additive manufacturing processes to understand the printability of custom polymer formulations

Greater Boston Area

• Increased the reliability of pH responsive materials for a safety mechanism in ultra-long lasting oral dosage forms• Method development using HPLC for characterizing new drugs for release properties and solubility• Performed initial development of coatings as a controlled release mechanism of drug polymer formulations

Greater Boston Area

• Confirmed the effect of titanium nanoparticles on increasing compatibility with muscle cells and disrupting bacteria growth• Performed Contact Angle measurements and calculations of nanoparticle coated plates to measure surface energy• Synthesized chitosan coated selenium nanoparticles and determined the mechanism of bacteria growth kinetics inhibition using the Gompertz and Richards Growth Model• Presented research at the Annual AICHE Conference in San Francisco Titled “Chitosan-Coated Selenium Nanoparticles and Their Effects on Bacterial Growth Kinetics”• Co-Author, “Decreased bacterial growth on titanium nanoscale topographies created by ion beam assisted evaporation”

Greater Boston Area

• Developed 350-line Python Modeling program to predict electrical and thermal conductivity of composite materials• Developed composite materials to make foam more robust, analyzed using SEM, FTIR, and tested material mechanical properties• Researched and created an experiment to test small-scale piezoelectric materials for energy harvesting applications• Wrote and presented report on current mobile device technology using FTIR and microscopy

Tarragona, Spain

•Performed optimization experiments of the degradation of cellulose for use in developing bio-plastics•Used FTIR, TOC, HPLC, and SEM for characterization•Second place at the National AICHE Conference in Salt Lake City for the Undergraduate Poster Competition in the Sustainability Section entitled “Comparing Cellulose Hydrolysis under Microwave and Autoclave Conditions”

Greater Boston Area

• Performed asset walk downs of facility equipment and tagged for Preventive Maintenance• Used computerized maintenance management system to make daily updates and reports to track maintenance issues• Improved process efficiency for CIP skids by making processing changes• Trained for clean room and Good Manufacturing Practices

• Identified documentation issues and created 40-slide PowerPoint proposal to recommends documentation process changes• Presented three spreadsheets with pivot tables showing bug reports and sales for the year• Tracked wins and losses for Provider Access Business Unit Engineering Division’s sales