Nicholas Bushby Email & Phone Number

Manchester, England, Gb

Manchester, England, United Kingdom

Supporting the commissioning and operation of radionuclide laboratories

Manchester Area, United Kingdom

Managing the safety, health, and environment requirements of an AstraZeneca research anddevelopment site and acting as chemical and radiation safety specialist to multiple AstraZenecasites across the UK

Manchester, United Kingdom

-Responsible for radiation safety advice at 5 AstraZeneca sites throughout the UK-Ensure compliance with Ionising Radiations Regulations 1999 and radiation permits-Lead interactions with regulator (Environment Agency) and radiation protection advisers-Provide advice to laboratory scientists, site management, waste handlers and logistics on work with all ionising radiation sources-Maintain source accountancy software-Applied for and granted new EPR radiation permits for new… Show more -Responsible for radiation safety advice at 5 AstraZeneca sites throughout the UK-Ensure compliance with Ionising Radiations Regulations 1999 and radiation permits-Lead interactions with regulator (Environment Agency) and radiation protection advisers-Provide advice to laboratory scientists, site management, waste handlers and logistics on work with all ionising radiation sources-Maintain source accountancy software-Applied for and granted new EPR radiation permits for new research facilities and varied existing permits-Co-ordinating decommissioning of radiochemistry facilities-Supporting work with a variety of radiation sources, including: Open source work with different beta-emitting isotopes (H-3, C-14, P-32/33)Imaging work with PET & SPECT isotopes (F-18, In-111, Tc-99m)X-Ray equipment (irradiators, XRF, XRD)Sealed sources Show less

Alderley Park, Macclesfield, Uk

-Managing the isotope chemistry needs of a portfolio of drug projects across all stages of development-Planning and carrying out the delivery of radiolabelled drug substance to cGMP standard for use in clinical trials. Working collaboratively across functions to bring together data and produce regulatory CMC documents in time for IMPD submission-Commissioning cGMP syntheses from 3rd party providers-Working to appropriate quality standards including cGMP and GLP and acting as GLP… Show more -Managing the isotope chemistry needs of a portfolio of drug projects across all stages of development-Planning and carrying out the delivery of radiolabelled drug substance to cGMP standard for use in clinical trials. Working collaboratively across functions to bring together data and produce regulatory CMC documents in time for IMPD submission-Commissioning cGMP syntheses from 3rd party providers-Working to appropriate quality standards including cGMP and GLP and acting as GLP study director.-Understanding the requirements of my major customers (drug metabolism, bioanalysis) in order to advise them and deliver material that meets their needs-Taking strategic decisions on whether to carry out work in-house or at an external company and then taking responsibility for all aspects of the delivery-Developing new methodologies for the isotopic labelling of drug compounds-Providing supervision and coaching to staff and students to enable them to develop and meet their objectives-Acting as Departmental Radiation Protection Supervisor (DRPS) for drug safety department. Taking responsibility for radiation safety in my laboratory and providing assistance and guidance to local Radiation Protection Supervisors in other labs Show less

Synthesis of small libraries of compounds using automation and solid-phase synthesis.

Bude, Uk

Developing chemistry for synthesis of large libraries of compounds