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Understanding the importance of residue motion in enzyme activity may eventually allow us to develop methods to modify, modulate and/or design new protein functions, which would have far-reaching implications in biotechnology, protein engineering, nanotechnology and drug design.The main goal of our research is to successfully modify enzyme biocatalysts aimed at environmental and pharmaceutical applications, with a broader interest focused on understanding the role between structure, function and flexibility in various enzymatic systems.To address this important problem, our research strategy combines directed evolution experiments coupled with biochemical and biophysical characterization such as nuclear magnetic resonance (NMR), molecular biology, enzyme kinetics, and molecular modeling. Using this approach, we specifically focus on achieving the following aims:1- To understand how the amino acid sequence and local structural environment of conserved residues determine the motional and functional properties of enzymes.2- To investigate how functionally and structurally related enzymes retain their motional properties within similar folds.3- To modify, reproduce and apply this 'structure-function' and 'flexibility-function' information to the design of new and improved molecular biocatalysts.
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Full ProfessorInstitut National De La Recherche ScientifiqueLaval, Qc, Ca
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Full ProfessorInstitut National De La Recherche Scientifique Jun 2019 - PresentMontreal, Quebec, Canada
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Associate ProfessorInstitut National De La Recherche Scientifique May 2015 - Jun 2019Montreal, Canada Area
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Assistant ProfessorInstitut National De La Recherche Scientifique Aug 2010 - May 2015Montreal, Canada Area
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Postdoctoral AssociateYale University Careers Sep 2007 - Jul 2010NMR Relaxation and Enzyme Catalysis, J. Patrick Loria Lab, Chemistry Department
Nicolas Doucet Skills
Nicolas Doucet Education Details
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Chemistry
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Biochemistry -
Biochemistry
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Biochemistry
Frequently Asked Questions about Nicolas Doucet
What company does Nicolas Doucet work for?
Nicolas Doucet works for Institut National De La Recherche Scientifique
What is Nicolas Doucet's role at the current company?
Nicolas Doucet's current role is Full Professor.
What is Nicolas Doucet's email address?
Nicolas Doucet's email address is ni****@****inrs.ca
What is Nicolas Doucet's direct phone number?
Nicolas Doucet's direct phone number is +145068*****
What schools did Nicolas Doucet attend?
Nicolas Doucet attended Yale University, Université De Montréal, Université De Montréal, Université Laval.
What skills is Nicolas Doucet known for?
Nicolas Doucet has skills like Biochemistry, Molecular Biology, Protein Engineering, Nmr, Molecular Modeling, Protein Chemistry, Lifesciences, Chemistry, Drug Design, Biotechnology, Enzyme Kinetics, Enzymes.
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Nicolas Doucet
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