Human Virtual Modeling - Virtual Twin Technology

As a Clinical Specialist I✔ Provide clinical support and training to neurosurgeons and surgical teams using the ClearPoint® system (Hardware + Software) during MRI-guided neurosurgical procedures.✔Develop novel computational models for neurosurgery treatment planning and quantification (Neuromodulation, Drug Delivery, Biopsy and Laser Ablation). ✔ Contribute to the 510k FDA submission process of novel software for neurosurgery (document control, validation, data processing).✔ Provide liaison between surgeons and the R&D team to ensure product feedback is communicated and help ensure continuous improvement and innovation of the system.ClearPoint provides real-time MRI guidance for a range of minimally invasive procedures in the brain (e.g., biopsies, catheter and electrode placement, drug delivery, and laser ablation) and can be used in both diagnostic and intraoperative MRI suites. It is currently used in clinical and pre-clinical practice.

- Lead the development of a universal virtual brain model on the 3DExperience platform from an MRI brain Atlas for patient-specific multi-physics FEA simulation of disease or treatment development.- Oversee the development of a brain implant medical device for vision-impaired patients using a brain virtual twin.- Focus on human physiological system modeling on the 3DExperience platform for applications toward precision medicine, surgery planning, diagnostic method calibration, and medical device design and FDA approval.- Initiate efforts towards creating a whole-body human Virtual Twin, with involvement in the Living Heart project and a specific focus on modeling the central nervous system.

- Spearheaded the creation of an innovative data processing pipeline to enhance MRI-based diagnostics for neurodegenerative diseases, boosting specificity.- Utilized multi-scale compartmental modeling techniques to derive cellular-level insights from macroscopic MRI data.- Pioneered the introduction of novel quantitative biomarkers for evaluating the progression of aging within the white matter of the human brain based on a transversely isotropic model of white matter for magnetic resonance elastography.

- Independently managed communication between medical surgeon and engineering lab to design novel bio-system CAD model for bio-compatible vascular grafts conditioning.- designed and optimized a flow system for shear stress conditioning of endothelial cells in vascular grafts lumen prior to surgery in swine.

- Led data collection on encapsulation efficiency of doxycycline in PLGA/PCL nanoparticles for drug delivery applications.- Assessed cellular responses in 3D cell culture models.- Characterized neovascularization with confocal microscopy.- Optimized processes to achieve desired 5-week sustained release.

- Developed a polymeric loading platform to optimize nanoparticle synthesis for CT/MRI contrast enhancement.- Collected and analyzed data using scanning electron microscopy techniques.