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Nicolas Rivron Email & Phone Number
Co-Founder
at
dawn-bio
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Nicolas Rivron is listed as Co-Founder at dawn-bio, a with 8 employees, based in Austria. AeroLeads shows a matched LinkedIn profile for Nicolas Rivron.
Nicolas Rivron previously worked as Principal Investigator at Imba - Institute Of Molecular Biotechnology, Vienna, Austria and Guest at Hubrecht Institute, Developmental Biology And Stem Cell Research. Nicolas Rivron holds Doctor Of Philosophy (Phd), Vascular Development, Tissue Engineering from University Of Twente.
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About Nicolas Rivron
Stem cell-based embryo models have emerged as powerful scientific and ethical alternatives to the use of embryos in research. Nicolas Rivron led the development of the first complete embryo model. It reflects the blastocyst in mice (2018, Nature) and humans (2021, Nature) and is named blastoid. Blastoids are unique in two respects: they are complete and thus allow the study of embryogenesis as a whole, and they represent the pre-implantation stage thereby enabling implantation in utero and ultimately the study of all subsequent stages (e.g. gastrulation, organogenesis). Using blastoids, the Rivron lab explores (1) the conserved principles of embryonic self-organization, focusing on the coordination and pacing of molecular and mechanical signalings in the context of human heterochronies, and (2) the human genetic traits that have led to our low fecundity compared to other primates (50% of fertilized oocytes never develop). This fundamental research aims to uncover the evolutionary constraints and vulnerabilities of human embryogenesis, knowledge of which is necessary for the development of novel therapeutic approaches to global health challenges such as family planning, fertility decline and prenatal preventive medicine. Nicolas Rivron is co-founder of dawn-bio, a biotech company that leverages blastoids for human reproductive medicine. These advances have ethical implications. Nicolas Rivron is contributing to drawing a roadmap for the gradual, justifiable use of embryo models, and for the dissemination of a sensible, accurate picture of contemporary human embryology that aim to maximize public support and societal benefit. Some of these activities have been carried out within the framework of the International Society for Stem Cell Research (2018-2021), national ethics committees (UK parliament & G-SCBEM, France, Netherlands, Germany, Scandinavia, EU consortium HYBRIDA; 2021-today) and the EMBL Ethics Board (2024-today).
Listed skills include Biomedical Engineering, Stem Cells, Regenerative Medicine, Developmental Biology, and 2 others.
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Dawn-Bio
8 roles · 27 years
Nicolas Rivron work experience
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Principal Investigator
Leading an academic laboratory (~10 people) working on mouse and human blastoid development and implantation.www.imba.oeaw.ac.atwww.blastoid.orgThe blastocyst is the early mammalian organism before implantation (day 5 for mice, day 9 for humans). We discovered how to promote the self-organization of stem cells into structures remarkably resembling the mouse and human blastocysts, and called this embryo model blastoid. Blastoids are morphologically and transcriptionally similar to the blastocyst and contain analogs of all three cell types that further develop into the complete organism (embryonic and extra-embryonic tissues/organs). Because blastoids model the pre-implantation stage, they can be introduced into the uterus of a mouse (mouse blastoid) or combined with uterine cells in vitro (human blastoid) to recapitulate aspects of the hidden processes of implantation. Contrary to blastocysts, blastoids are versatile in that they facilitate the more systematic modulation and analysis of the impact of cell numbers, states, and communication mechanisms on development. Blastoids are also amenable to screenings and complex genetic manipulations, which are at the base of scientific and biomedical discoveries. As such, they open previously inaccessible ways to investigate the interaction rules and design principles underlying embryonic development. Long-term, we anticipate that the knowledge gained using blastoids contributes in tackling global health issues of family planning, fertility decline, and of the developmental origin of health and diseases.Our group gathers embryologists, stem cell biologists, geneticists, engineers, and computational biologists. Our lab is grounded both in fundamental biology (self-organization, gene regulation, human evolution) and in technology development including microsystems, 3D high-content imaging, single cell genomics, and computational analysis.
Nov 2010 - Jul 2019
Principal Investigator
Merln Institute For Technology-Inspired Regenerative Medicine.
Leading an academic laboratory (~5 people) working on mouse blastoid development and implantation.
Feb 2013 - Jun 2019
Researcher
Mira Institute
Leading a personal research line (2 PhD students: : Erik Vrij and Javier Frias Aldeguer) on mouse blastoid development.Hosted at the Hubrecht Institute for stem cell biology and developmental research.
Nov 2010 - Feb 2013
Phd Candidate
Department of Tissue RegenerationVascular development for tissue regeneration.
2006 - Sep 2010
Research Scientist
Heart Valve Research Division, Santa Ana, USA Material and Bioscience Center, Minneapolis, USA.Cardiovascular medical devices.
2002 - 2004
~2 yrs
Research Trainee
Laboratory for Biomedical Microsensors/system, INSA Lyon, France - Prof. A. DittmarMicrotools for brain surgery.
2000 - 2001
~1 yr
2 education records
Nicolas Rivron education
Doctor Of Philosophy (Phd), Vascular Development, Tissue Engineering
Master'S Degree
FAQ
Frequently asked questions about Nicolas Rivron
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What company does Nicolas Rivron work for?
Nicolas Rivron works for dawn-bio.
What is Nicolas Rivron's role at dawn-bio?
Nicolas Rivron is listed as Co-Founder at dawn-bio.
Where is Nicolas Rivron based?
Nicolas Rivron is based in Austria while working with dawn-bio.
What companies has Nicolas Rivron worked for?
Nicolas Rivron has worked for Dawn-Bio, Imba - Institute Of Molecular Biotechnology, Vienna, Austria, Hubrecht Institute, Developmental Biology And Stem Cell Research, Merln Institute For Technology-Inspired Regenerative Medicine., and Mira Institute.
How can I contact Nicolas Rivron?
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What schools did Nicolas Rivron attend?
Nicolas Rivron holds Doctor Of Philosophy (Phd), Vascular Development, Tissue Engineering from University Of Twente.
What skills is Nicolas Rivron known for?
Nicolas Rivron is listed with skills including Biomedical Engineering, Stem Cells, Regenerative Medicine, Developmental Biology, Microfabrication, and High Throughput Screening.
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