Nicole M. Reilly, Ph.D. Email and Phone Number
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- Research scientist with 6+ years of post-graduate experience in fast-paced academic and industry settings.- Expertise in pharmacodynamic and predictive biomarker identification and validation, translational biology, molecular oncology, pre-clinical cell models, MOA studies, and cell-based assays.- Highly driven and detail-oriented with a passion for cancer drug development with the goal of translating preclinical discoveries into patient selection strategies.
C4 Therapeutics, Inc.
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Senior Research Scientist, Translational MedicineC4 Therapeutics, Inc. Jul 2024 - PresentWatertown, Ma, Us- Translational medicine scientist for clinical-stage programs performing laboratory-based confirmatory experiments for clinical biomarker strategies, supporting clinical assay development and implementation, and performing key experiments to inform on indication expansion opportunities.- Lead translational medicine scientist for pre-development candidate programs facilitating clinical biomarker assay development and implementation strategies, and performing laboratory-based experiments to support clinical trial design. -Engage cross functionally with Discovery Biology and Clinical Development teams to support candidate nomination activities, IND enabling studies, and clinical biomarker assay development.-Engage CROs to develop clinical biomarker assays for use in Phase I/II clinical trials and procurement of patient samples for ex vivo validation of biomarker strategies and indication expansion activities.
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Research Scientist Ii, Translational MedicineC4 Therapeutics, Inc. Mar 2023 - Jul 2024Watertown, Ma, Us
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Senior Scientist, Translational ResearchCyteir Therapeutics Jan 2022 - Feb 2023Lexington, Ma, Us- Lead laboratory scientist for reverse translational studies of the clinical-stage monocarboxylate transporter inhibitor CYT-0851.- Utilized cellular- and molecular-based assays, including cell viability assays, generating stable over-expression cell models, western blot, and qPCR methods, to validate putative predictive and pharmacodynamic biomarkers for CYT-0851.- Performed gene set enrichment and over-expression analysis of preclinical RNA-seq and metabolomics data to identify novel predictive and pharmacodynamic biomarkers.- Worked collaboratively with Discovery and Platform Biology Groups to develop over-expression and knockdown/out cell models to perform MOA studies and test biomarker hypotheses for CYT-0851.- Worked with CROs to establish a clinical-use IHC assay, validate pharmacodynamic biomarkers using proteomic analyses, and produce custom antibodies for in-house validation studies. -
Airc Postdoctoral Research FellowCandiolo Cancer Institute Irccs Feb 2018 - Dec 2021Candiolo, It-Recepient of the Associazione Italiane per la Ricerca sul Cancro (AIRC) Post-Doctoral Fellowship which funded 3 years of research.- Established cell- and molecular-based techniques in the laboratory to characterize a composite biomarker to predict cellular response to clinical-stage ATR inhibitors (Durinikova E, Reilly NM, et al, Clinical Cancer Research, 2022), to measure DNA damage induction and functional loss of DNA repair pathways after EGFR and BRAF inhibition (Russo M, et al, Science, 2019), and to correlate DNA repair proficiency with cellular sensitivity to colibactin-induced genotoxic stress (Sogari et al, Cell Reports Medicine, 2024). -Formed a successful collaboration with an industry partner to investigate a clinical-stage molecule in clinically relevant colorectal cancer cellular and patient derived experimental models. - Utilized CRISPR-Cas9 technology to identify novel resistance mechanisms to standard-of-care therapy regimens used for the treatment of colorectal cancer. Candidates were validated using cell-based sensitivity assays, WB, and IF techniques.- Formed successful internal collaborations with fellow laboratory members and external collaborators with industry partners.- Mentored one master’s student (now PhD student) and one MD/PhD student. -
Graduate Research AssistantUniversity Of South Carolina Jul 2012 - Jan 2018Columbia, Sc, Us- Utilized molecular mutagenesis tools, genetic complementation assays, immunofluorescence microscopy, and DNA damage repair assays to identify two lysine residues along the RAD51D protein which are required for cellular repair of DNA inter-strand crosslinks (Yard BD, Reilly NM, et al, DNA Repair, 2016) and further demonstrated that RAD51D functions to maintain telomere integrity in response to 6-thioguanine damage (Wyatt MD, Reilly NM, et al, Environmental and Molecular Mutagenesis, 2018). - Utilized microarray and RNA Seq bioinformatic technologies to characterize gene expression alterations and genomic fusions and translocations in Rad51d-deficient mouse embryonic fibroblast cells.- Mentored five undergraduate and two pharmacy students. - Presented twenty-eight abstracts, including three posters and two flash talks at the 2016 Environmental Mutagenesis and Genomics Society international conference. -
Research AssistantAppalachian State University Oct 2008 - Jul 2012Boone, Nc, UsDuring my undergraduate studies, the goal of my research project was to develop an in vivo biosensing system to measure the inactivation of beta-lactam antibiotics.
Nicole M. Reilly, Ph.D. Skills
Nicole M. Reilly, Ph.D. Education Details
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University Of South CarolinaPharmaceutical Sciences -
Appalachian State UniversityForensic Science
Frequently Asked Questions about Nicole M. Reilly, Ph.D.
What company does Nicole M. Reilly, Ph.D. work for?
Nicole M. Reilly, Ph.D. works for C4 Therapeutics, Inc.
What is Nicole M. Reilly, Ph.D.'s role at the current company?
Nicole M. Reilly, Ph.D.'s current role is Translational Medicine | Biomarker Discovery | Molecular Oncology | DNA Repair.
What is Nicole M. Reilly, Ph.D.'s email address?
Nicole M. Reilly, Ph.D.'s email address is ni****@****eir.com
What is Nicole M. Reilly, Ph.D.'s direct phone number?
Nicole M. Reilly, Ph.D.'s direct phone number is +3933189*****
What schools did Nicole M. Reilly, Ph.D. attend?
Nicole M. Reilly, Ph.D. attended University Of South Carolina, Appalachian State University.
What skills is Nicole M. Reilly, Ph.D. known for?
Nicole M. Reilly, Ph.D. has skills like Molecular Biology, Western Blotting, Microscopy, Gel Electrophoresis, Fluorescence Microscopy, Polymerase Chain Reaction, Molecular Cloning, Confocal Microscopy, Statistics, Biochemistry, Mammalian Cell Culture, Protein Expression.
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