Niharika Singh Email & Phone Number

Cardiff, Gb

Valencia, Valencian Community, Spain

Combining epigenetics and computational bioinformatics, I am working on creating a scaled-down model of Horvath's Clock, enhancing our grasp of biological aging and providing accessible tools for clinicians and researchers in aging studies.

Cardiff, Wales, United Kingdom

I am supervised by Dr. Isabel Martinez-Garay, Dr. Florian Siebzehnrubl, and Dr. You Zhou.The key focus of my project are the following: 1. The interaction dynamics of the transcription factor Zeb1 in adult hippocampal neural stem cells (NSCs) to determine the impact their loss has on NSC output, i.e., increasing the number of neurons that are produced at the expense of glial cells.2. Prospective role of Zeb1 in the production of glial cells during development.3. Elucidating… Show more I am supervised by Dr. Isabel Martinez-Garay, Dr. Florian Siebzehnrubl, and Dr. You Zhou.The key focus of my project are the following: 1. The interaction dynamics of the transcription factor Zeb1 in adult hippocampal neural stem cells (NSCs) to determine the impact their loss has on NSC output, i.e., increasing the number of neurons that are produced at the expense of glial cells.2. Prospective role of Zeb1 in the production of glial cells during development.3. Elucidating its function in mature astrocytes. Show less

Investigating the underlying mechanisms of neurite length asymmetry and co-orientation in neural explants containing dorsal root ganglion from E8 chick embryos.

Delhi, India

Investigating the impact of huntingtin aggregates on the self-renewal activity of asymmetrically dividing neuroblasts in the brain of transgenic Drosophila melanogaster (UAS Htt ex1 PQ93).

Chennai, Tamil Nadu, India

Computational modelling of the STN-GPe subsystem of the basal ganglia and their role in exploratory dynamics. Neuronal oscillations were modelled and resulting changes from altering corticothalamic and hyperdirect current was analysed to investigate their impact on the exploratory output of the basal ganglia. Working on this project, I was able to delineate the underlying neuronal coupling that manifests as a bradykinetic state and lowered exploration observed in patients of Parkinsonian… Show more Computational modelling of the STN-GPe subsystem of the basal ganglia and their role in exploratory dynamics. Neuronal oscillations were modelled and resulting changes from altering corticothalamic and hyperdirect current was analysed to investigate their impact on the exploratory output of the basal ganglia. Working on this project, I was able to delineate the underlying neuronal coupling that manifests as a bradykinetic state and lowered exploration observed in patients of Parkinsonian disorders. Show less

Kolkata, West Bengal, India

Kolkata, West Bengal

I worked on a project in the Laboratory of Toxicology, Division of Molecular Medicine for a period of one month and my project encapsulated the oxidative stress ameliorating effects mediated by the drug Taurine on the Streptozotocin induced diabetes in rats.

Doctor Of Philosophy - Phd, Neuroscience

Msc Dissertation, Computational Neuroscience

Computational modelling of the exploratory dynamics in the STN-GPe subsystem of the basal ganglia, studied during deep brain stimulation.

Masters, Neuroscience, 1St Class, First

Bachelor'S Degree, Zoology Honours, First Class With Distinction

Activities and Societies: Debate, National Social Scheme (NSS),Quiz Represented my college in debates organized by various organizations.

School, 95% In Isc

Activities and Societies: Senior Prefect,Debates,Quizzes, President of Psychology Club, Editorial Board member