Thesis title: New signal transduction methods for cucurbit[n]uril-based chemosensors- Developed supramolecular analytical assays based on novel signal transduction methods for the detection of biologically important analytes.- Established proof-of-concept solutions for molecular diagnostics that can be implemented in homes or point-of-care units.- Involved in the automation project to optimize a high-throughput automated workflow for screening sensing assays.- Acquired proficiency in various instruments including UV-Vis and Fluorescence spectrometer (JASCO), NMR spectrometer (Bruker Ultrashield plus 500), IR spectrometer (Perkin-Elmer), ESI-ToF Mass spectrometer (Bruker), HPLC (JASCO), Multimode Microplate Reader (Perkin Elmer and BMG Labtech), Pipetting Robot (Opentrons OT-2), and Portable bipotentiostat/galvanostat for electrochemical measurements (Metrohm).- Teaching assistantship in protein isolation practical course for undergraduate students.

Project: Design and synthesis of DNA-oligohexaphenylbenzene bolaamphiphiles and their self-assembly into DNA-decorated 2D nanosheets- DNA-hexaphenylbenzene bolaamphiphiles were synthesised using solid phase oligonucleotide synthesizer.- Systematically the number of hexaphenylbenzene units was increased to investigate the stability of 2D nanosheets.

Project: Kinetochore-microtubule interaction: role of S𝑘𝑎1 SHLP motif- Introduced various point mutations in Ska1 (Spindle and kinetochore assisted protein) SHLP motif through site-directed mutagenesis.- Studied the effect and phenotype characterisation of these mutations in mammalian cells using confocal microscopy.

Project: Synthesis of galactose-hexaphenylbenzene conjugates and their self-assembly into galactose-decorated 2D nanosheets- Galactose-hexaphenylbenzene conjugates were synthesised using multistep organic synthesis.- Formation of 2D nanosheets by the self-assembly of bolaamphiphiles was confirmed using microscopic techniques.

Project: Synthetic approach for the synthesis of n-fused heterocyclic derivatives- Synthesised N-fused indoles using direct catalytic cyclisation.- Characterisation of the compounds was performed using NMR spectroscopy.