Senior Scientific Manager (Chemistry Synthesis) I am a passionate synthetic organic chemist. Experience in custom synthesis (CRO's), route scouting, route selection, process development of pharmaceutically active compounds. Designing of the novel, robust, cost effective, scalable routes as per client requirement. Updating the progress of the project in terms of weekly/ biweekly telecommunication and email.

Research Scientist (Team Leader, Route Scouting and Process Development Department) The activity which includes route scouting, route selection, Proess Development. Designing of the novel, robust, cost effective, scalable routes as per client requirement. Directly dealing with UK and USA based clients and updating the progress of the project in terms of weekly/ biweekly telecommunication and email. Report/ Proposal writing upon request of clients.

Job responsibility includes team handled, Lab set up, Design, Establishment of cost effective and scalable processes effectively. Discusses and presents work responsibly at group/project meetings in the context of team goals. Development of API molecules and process development of various intermediates. Translated small scale reaction conditions in to larger scale to allow synthesis in kilogram quantities.Route scouting, route selection, paper costing, feasibility studyDevelopment of… Show more Job responsibility includes team handled, Lab set up, Design, Establishment of cost effective and scalable processes effectively. Discusses and presents work responsibly at group/project meetings in the context of team goals. Development of API molecules and process development of various intermediates. Translated small scale reaction conditions in to larger scale to allow synthesis in kilogram quantities.Route scouting, route selection, paper costing, feasibility studyDevelopment of processes at bench scale level / parameter optimizationProcess validation impurities identification and impurities profiling Show less

Job responsibility includes team handled, Job responsibility includes scaling up lab technology to pilot and commercial scale in coordination with Technology and production team and also the establishment of cost effective and scalable processes effectively. Discusses and presents work responsibly at group/project meetings in the context of team goals. Development of generic molecules and process development of various intermediates and Active Pharmaceutical Ingredients(API):Translated… Show more Job responsibility includes team handled, Job responsibility includes scaling up lab technology to pilot and commercial scale in coordination with Technology and production team and also the establishment of cost effective and scalable processes effectively. Discusses and presents work responsibly at group/project meetings in the context of team goals. Development of generic molecules and process development of various intermediates and Active Pharmaceutical Ingredients(API):Translated small scale reaction conditions to larger scale to allow synthesis in kilogram quantities.The main responsibilities were:Route scouting, route selection, paper costing, feasibility studyDevelopment of processes at bench scale level / parameter optimizationProcess validation impurities identification and impurities profiling Show less

Scale up’s and Process Development Experience During Piramal Enterprises Ltd (Kilo-Lab as well as in Medicinal Chemistry).Involved in the scale up’s as well as development of good process for the synthesis of expensive intermediate (which is a key intermediate for P1736 is in Phase II clinical trials for metabolic disorder) drastically reduces the cost as well as synthetic steps.Involved in the scale up’s as well as process development for PL225B is in Phase I clinical trials for… Show more Scale up’s and Process Development Experience During Piramal Enterprises Ltd (Kilo-Lab as well as in Medicinal Chemistry).Involved in the scale up’s as well as development of good process for the synthesis of expensive intermediate (which is a key intermediate for P1736 is in Phase II clinical trials for metabolic disorder) drastically reduces the cost as well as synthetic steps.Involved in the scale up’s as well as process development for PL225B is in Phase I clinical trials for anticancer project.Involved in the scale up’s as well as process development of final step of P11187 which drastically reduced solvent for extraction of final step as well as time.Involved in the scale up as well as process optimization of many final molecules as well as their key intermediates and delivered the same within timelines.Medicinal Chemistry Experience:Involved in design and synthesis of analogues for developing a GPR40 inhibitor that would qualify internal candidate selectioncriteria’s to be nominated as an IND. P11187 for GPR40 inhibitor is presently undergoing Phase I Clinical trials.Actively involved towards synthesizing an IND (PL225B) for anticancer and its back-up molecule. PL225B is presently undergoing Phase I clinical trials.Involved in the synthesis of multi-gram to kilogram scale-up of candidate molecules for IND-enabling studies.Actively involved in the design, synthesis, and characterization of molecules.Provide regular project updates in the form of presentations in group meetings.Prepare literature as per requirements for patents, journal manuscripts and poster presentations. Show less