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Drug hunter with 20+ years of medicinal chemistry research across pharma, biotech, and techbio companies with focus on oncology, cardiovascular, immunology, and CNS/neuro indications.. Well versed in strategic research group and program management and team building skills, complemented by a creative spirit, energy, and enthusiasm for solving complex problems. Passionate about the application of target unbiased cellular and whole animal phenotypic assays to identify novel drugs for challenging diseases/Specialties: 1) Experienced Head of Chemistry and project leader advancing multiple compounds to IND filing across a variety of therapeutic indications. 2) Phenotypic drug discovery to identify CNS, fibrotic, and oncology drugs with unprecedented mechanisms of action.2) Structure-based & rational drug design in the development of aspartyl protease, serine protease, & kinase inhibitors, as well as agonists/antagonists of calcium channels, nuclear hormone receptors, & GPCRs and protein misfolding/trafficking correctors.3) Integration of external contract resources into project teams
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Owner And WinemakerAaronap CellarsWestford, Ma, Us -
Senior DirectorRecursion Jan 2023 - PresentSalt Lake City, Utah, UsStrategic management of AI-driven phenotypic drug discovery projects for an external partner. -
Owner & WinemakerAaronap Cellars Sep 2011 - PresentOwner, Chief Executive Officer, President of Winemaking, Senior Director of Tank Scrubbers, Chief Bottle Washer, & Lead Salesperson for a microwinery producing 850 gallons/year of premium red, white, & dessert wines using fruit sourced from select partner vineyards in New England and beyond. Yankee ingenuity meets wine!www.aaronapcellars.com
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Senior Director / Head Of ChemistryDelix Therapeutics Jun 2020 - Dec 2022Boston, Massachusetts, UsHead of Medicinal chemistry group leader for emerging CNS focused biotech. Responsible for the advancement of programs through IND-enabling studies using 100% external chemistry, biology, DMPK, toxicology, & CMC resources. Built a platform of psychedelic-inspired neuroplastinogens for the treatment of a wide variety of CNS diseases -
DirectorSunovion Pharmaceuticals Apr 2019 - Jun 2020Marlborough, Ma, Us -
Associate DirectorSunovion Pharmaceuticals Apr 2013 - Apr 2019Marlborough, Ma, UsPioneered medicinal chemistry strategies for SAR using whole animal phenotypic behavioral assays to identify novel CNS agents. Oversaw large external chemistry groups and drove in vitro and in vivo pharmacology & DMPK screening through CRO collaborators.
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Senior ScientistEisai Research Institute Jul 2012 - Dec 2012Optimized a lead series of kinase inhibitors for the treatment of B-cell mediated autoimmune diseases
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Senior Scientist IiProteostasis Therapeutics, Inc. Jul 2011 - Jun 2012Triaged screening hits and identified 2 lead series of small molecule dF508-CFTR correctors with activity in human primary bronchial epithelial cells for the treatment for cystic fibrosis. Managed 6 external chemistry FTEs and additional external pharmacology resources.
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Principal ScientistBiogen Idec Feb 2011 - Jul 2011Cambridge, Ma, Us-Project leader of a Hit-to-Lead & Lead Optimization stage project in Immunology. -Successfully managed external screening program and hit-to-lead triage to identify two series of nuclear hormone receptor inverse agonists that were selected for advancement to Lead Optimization.-Project staffed through 100% external chemistry resources.-Matrix contributed to a late stage kinase project targeted B-cell mediated autoimmune diseases and contributed to identification of compound that was selected for clinical development. -
Senior ScientistBiogen Idec Aug 2007 - Feb 2011Cambridge, Ma, Us-Project leader of a Candidate Selection stage project in Oncology. -Designed follow-up project strategy that successfully identified two series of novel pan-Raf inhibitors that were advanced from initial design to pre-clinical development candidate selection in less than 14 months.-Directed team of internal PhD & MS chemists in addition to 6-10 external chemistry FTEs.
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Senior Principal ScientistPfizer Inc Sep 2000 - Aug 2007New York, New York, UsResearch goals targeted the discovery of small molecule inhibitors of renin, serine proteases, and kinases, as well as calcium channel and GPCR antagonists, for the treatment of hypertension, thrombosis, metabolic syndrome, & atherosclerosis.-Project leader of early stage Sky Kinase project. Triaged HTS hits and identified 2 series of ATP-competitive inhibitors that demonstrated exquisite selectivity against the kinome. Successfully optimized the potency & ADME/PK properties of one series and identified orally available, potent, & selective inhibitors that were used to demonstrate in vivo POC.-Discovered & developed a series of non-peptidomimetic small molecule inhibitors of renin. Optimized potency and PK properties utilizing structure-based drug design, NMR fragment screening, & isothermal calorimetry.-Supervised 3 BS/MS internal chemistry FTEs and directed the research of a team of 6 MS/PhD level external FTEs. -
Nih Postdoctoral FellowUniversity Of Michigan Sep 1998 - Sep 2000Ann Arbor, Michigan, UsSynthesized analogs of aureolic acid to determine structural requirements for DNA binding. Developed new methodology for the diastereoselective synthesis of propargylic 1,2-anti-diols. Proposed synthetic route towards the natural product formamicin and completed synthesis of the C1-C11 fragment.
Noel Powell Skills
Noel Powell Education Details
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Uc IrvineOrganic Synthesis -
University Of MichiganChemistry
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University Of MinnesotaOrganic Chemistry
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Central CollegeChemistry
Frequently Asked Questions about Noel Powell
What company does Noel Powell work for?
Noel Powell works for Aaronap Cellars
What is Noel Powell's role at the current company?
Noel Powell's current role is Owner and Winemaker.
What is Noel Powell's email address?
Noel Powell's email address is na****@****ast.net
What is Noel Powell's direct phone number?
Noel Powell's direct phone number is +173442*****
What schools did Noel Powell attend?
Noel Powell attended Uc Irvine, University Of Michigan, University Of Minnesota, Central College.
What skills is Noel Powell known for?
Noel Powell has skills like Drug Discovery, Drug Design, Medicinal Chemistry, Chemistry, Organic Chemistry, Clinical Development, Organic Synthesis, Lead Change, Adme, Nmr, Research, High Throughput Screening.
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