Sophie Noel Email & Phone Number

Thuillies, Région Wallonne, Belgique

CLINIX Training - Certification in Clinical Research Professionals to complete my research experience and to pursue my career in the Clinical research field (ULB HeLSci, 10/2019 - 01/2020)An ideal gateway to a wide range of clinical research professions: Theoretical and practical training covering all aspects of Drug Development, Drug Safety, Study Design, Protocol Writing, Implementing Clinical Trials, GCP & Quality management, Clinical Data Management, Regulatory Affairs, Pharmacovigilance and Health Economics.Strengthening PEOPLE & PROJECTS MANAGEMENT skills through certification in collaborative leadership (FUCAM, UCL, 01- 06/2019) and Prince 2® certification (B2Blearning, 09-2019). Expanding knowledge in Stem cells & Cell therapy, Flow cytometry, Quality and GMP (ULB HeLSci, 05 to 07/2019)

Gosselies, Belgium

PRECLINICAL PROJECTS MANAGEMENT from early stage to clinical candidate selection:- in vitro ADME profiling and Assay Development according FDA guidelines. Screening of drug candidates for internal and external projects in usual ADME/TOX assays. - in vivo activities and Animal Laboratory (Pharmacokinetics, Pharmacodynamics, Efficacy studies and Animal models development on rodents). Elaboration of ethical and experimental in vivo protocols.- Bioanalyses for in vitro and in vivo studies. Development and optimisation of new analytical methods and procedures by LC/MS-MS.SUPPORT CLINICAL LEAD PROJECT- Identification of one clinical candidate, as specific antagonist for NK3 (CNS target). - Set up assays to define drug metabolism and new approaches leading to drug-drug interactions studies as well as evaluation of drug potential toxicity.- Management of samples bioanalyses and follow up of the method validations with CRO - Support in writting the IND filling (preclinical studies results).- Coordination all profiling assays of competitors- Support due diligence and management of project information transfer to ASTELLASPEOPLE MANAGEMENT-Training and supervision of the team (Technicians and research associates; 8 people)-Optimisation timelines for results delivery and reinforcement team spirit.

Gosselies, Belgium

- Development of usual ADME/TOX assays for compound profiling (Cytotoxicity on HEPG2, CYP inhibition, Plasma Protein Binding, Metabolic stability (Phase I & II), Permeability in Caco2 cells lines, Plasma Stability, hERG binding, Drug transporter (Pgp, OATP), Liver toxicity evaluation)- Management of all ADME profiling for internal and external programs- People management (Training, supervision of 2 research associates)

Bruxelles, Belgium

- Development of extraction protocols from biological matrix in order to identify natural ligand for Orphan GPCRs- Responsible of the development of the Biological extract library for screening- Management of the extracts screening (96 and 384 wells) and hits confirmations - Purification and identification of natural ligands from specific activities - Follow up on two projects in collaboration with Novartis Pharma (Basel, Switzerland) - Coordination for Euroscreen of the European project FP6: “Functional Pharmacogenomics of G Protein-Coupled Receptors” (LSHB-CT-2003-503337)- People management (Training and team supervision (2 to 6 technicians))

Brussels

- Responsible for chemical and microbiological technical units in food quality control (Development of new analyses methods, analyses follow up and report writing, stock management and Technological follow up)- Quality Control on all DELHAIZE products and Specific qualitative analyses for customers- Implementation of the Quality system, Assays and quality procedures writing (norm EN45001)- People management (Training, supervision of 2 technicians)

Louvain-La-Neuve; Belgium

PhD in collaboration with INTERBREW and KRONENBOURG as Industrial partners (Financing by FRIA) Thesis subject: “Characterization of the aging beer precursors and revealing their formation during the brewing process” - Development of biochemical and microbiological analyses methods - Extraction, identification and quantification of beer aroma - Follow up of specific molecules through the brewing process and storage  - Training and supervision of students and technicians

Louvain-La-Neuve; Belgium

Research project in collaboration with INTERBREW and KRONENBOURG as Industrial partners: “Impact of oxygen in the headspace of bottled beer on the flavour stability”

Phd In Biosciences Engineering

Prince2® Certification, Project Management - 09/2019

Certificate In Collaborative Leadership- 01 To 06/2019

Master In Laboratory Animal Sciences (Level I) - 09/2012

Master In Biosciences Engineering, Chemistry And Bioindustries