Norrapat Shih

Norrapat Shih Email and Phone Number

Bangkok, TH
Norrapat Shih's Location
Boston, Massachusetts, United States, United States
Norrapat Shih's Contact Details

Norrapat Shih work email

Norrapat Shih personal email

About Norrapat Shih

I have a strong passion for developing therapeutics to improve patient's lives. This was why I started studying science in the first place. My Ph.D. in Pharmacology work was about developing peptides we isolated from snake venom and tick saliva as anticoagulant therapies for use in patients who come into the hospital with a heart attack. My current work is about the development of a novel protein drug as a therapy for a number of diseases e.g. Duchenne Muscular Dystrophy. My top scientific expertise: Preclinical Pharmacokinetics/Pharmacodynamics studies. In vivo pharmacology. Animal models. Animal surgery. Bioanalytical assay development. Ligand Binding Assays (e.g. ELISAs). Mass spectrometry. Solid-phase extraction. Liquid-liquid extraction.Apart from my scientific background, I've also had experience founding my own company and managing a small team of researchers to achieve a common goal.

Norrapat Shih's Current Company Details
Mithridates Therapeutics

Mithridates Therapeutics

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Co-Founder
Bangkok, TH
Employees:
1
Norrapat Shih Work Experience Details
  • Mithridates Therapeutics
    Co-Founder
    Mithridates Therapeutics
    Bangkok, Th
  • Harvard Medical School
    In Vivo Pharmacology & Bioanalytical Assay Development
    Harvard Medical School Jul 2022 - Present
    Boston, Ma, Us
    • Optimization of animal models for Duchenne Muscular Dystrophy to test the efficacy/safety of a novel protein therapeutic.• Development of bioanalytical assays (ELISA, mass spectrometry) for quantitation of a novel protein drug in pharmacokinetic / pharmacodynamic studies.
  • Dana-Farber Cancer Institute
    Postdoctoral Research Fellow
    Dana-Farber Cancer Institute Jul 2022 - Present
    Boston, Ma, Us
    • Optimization of animal models for Duchenne Muscular Dystrophy to test the efficacy/safety of a novel protein therapeutic.• Development of bioanalytical assays (ELISA, mass spectrometry) for quantitation of a novel protein drug in pharmacokinetic / pharmacodynamic studies.
  • National University Of Singapore
    Research Fellow
    National University Of Singapore Apr 2021 - Jun 2022
    Singapore, Sg
    • Developed an efficient peptidomics and glycoproteomics workflow for identification of novel plasma/platelet biomarkers of acute coronary syndrome. • Development of a microalgae-based air purifier. Microalgae extraction and analysis.
  • Etbio
    Co-Founder
    Etbio May 2019 - Aug 2020
    Singapore, Singapore, Sg
    • Development of a microalgae-based air purifier and algae extraction technology for large-scale ambient air CO2 removal.• Raised pre-seed investment.• Acquired 7 Letters-of-intent from customers and partner companies for trial and purchase of our device.
  • Freelance
    Consultant
    Freelance Jan 2017 - Aug 2020
    • Personally developed (or advised on the development of) bioanalytical quantitation assays for peptides/proteins, small molecule drugs and their metabolites.
  • Entrepreneur First
    Founder-In-Residence
    Entrepreneur First Jul 2018 - Jul 2019
    London, Gb
  • National University Of Singapore
    Phd Student/Research Fellow (Kini Lab / Mark Chan Lab/Spin-Off Company)
    National University Of Singapore Aug 2012 - Jul 2018
    Singapore, Sg
    • Designed and performed preclinical in-vivo models (rats, mice, pigs) to study the efficacy and safety of novel anticoagulant peptides derived from snake venom and tick saliva. Data acquired was used for fundraising activities with venture capital firms and liaising with CROs for ADME-tox and Phase I studies.• Initiated fundraising activities with venture capital firms and liaised with CROs for ADME-tox and Phase I studies.• Developed bioanalytical assays (LC-SRM, enzyme-based) and performed in-vivo animal pharmacokinetic studies for the anticoagulant peptides in rats and pigs. • Engineered a Plexiglas perfusion chamber for the porcine ex-vivo stent thrombosis model, without prior knowledge of engineering/design technology (I had to self-learn everything!). This perfusion chamber is now being used for Phase 0 clinical studies of our anticoagulant peptide.• Wrote and amended IACUC protocols and liaised with the animal use committee to obtain protocol approvals. • Managed a team of 3 research assistants for animal surgery procedures.
  • University Of Toronto
    Msc Student (Krause Lab)
    University Of Toronto May 2009 - May 2012
    Toronto, Ontario, Ca
    Identification of ligands for the orphan nuclear receptor PPARy (a target for many Type II Diabetes drug) from transgenic zebrafish:- Development/optimization of a protein purification protocol of a tagged-PPARy receptor fusion protein transgenically expressed in zebrafish embryos.- Optimization of a mass spectrometry method for identification of the endogenous ligand.
  • University Of Toronto
    Junior Research Assistant
    University Of Toronto Sep 2008 - May 2009
    Toronto, Ontario, Ca
    Development of an antibody targeting the cadherin domain of the drosophila melanogaster Cad88c protein.- Molecular cloning of the sequence encoding for cad88c antigen region into an expression vector- Heterologous expression of the Cad88c antigenic domain in E. coli- Protein purification of the expressed Cad88c antigenic domain
  • University Of Toronto
    Junior Research Assistant
    University Of Toronto Sep 2007 - May 2008
    Toronto, Ontario, Ca
    Forward genetic screen to identify mutant Arabidopsis thaliana with resistance towards Pseudomonas syringae bacteria.
  • National Nanotechnology Center (Thailand)
    Junior Research Assistant
    National Nanotechnology Center (Thailand) May 2007 - Aug 2007
    Liposome-based encapsulation of asiaticoside

Norrapat Shih Education Details

  • National University Of Singapore
    National University Of Singapore
    Analytical Chemistry
  • Online Gmp Training
    Online Gmp Training
    Good Laboratory Practice Certificate (Glp Nonclinical)
  • Singapore-Mit Alliance For Research And Technology - Innovation Fellow Program
    Singapore-Mit Alliance For Research And Technology - Innovation Fellow Program
    Entrepreneurial And Small Business Operations
  • University Of Toronto
    University Of Toronto
    Biochemistry And Molecular Biology
  • University Of Toronto
    University Of Toronto
    Developmental Biology And Embryology
  • Bangkok Patana School
    Bangkok Patana School
    High School Diploma
  • University Of Toronto
    University Of Toronto

Frequently Asked Questions about Norrapat Shih

What company does Norrapat Shih work for?

Norrapat Shih works for Mithridates Therapeutics

What is Norrapat Shih's role at the current company?

Norrapat Shih's current role is Co-Founder.

What is Norrapat Shih's email address?

Norrapat Shih's email address is no****@****ail.com

What schools did Norrapat Shih attend?

Norrapat Shih attended National University Of Singapore, Online Gmp Training, Singapore-Mit Alliance For Research And Technology - Innovation Fellow Program, University Of Toronto, University Of Toronto, Bangkok Patana School, University Of Toronto.

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