Norrapat Shih work email
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I have a strong passion for developing therapeutics to improve patient's lives. This was why I started studying science in the first place. My Ph.D. in Pharmacology work was about developing peptides we isolated from snake venom and tick saliva as anticoagulant therapies for use in patients who come into the hospital with a heart attack. My current work is about the development of a novel protein drug as a therapy for a number of diseases e.g. Duchenne Muscular Dystrophy. My top scientific expertise: Preclinical Pharmacokinetics/Pharmacodynamics studies. In vivo pharmacology. Animal models. Animal surgery. Bioanalytical assay development. Ligand Binding Assays (e.g. ELISAs). Mass spectrometry. Solid-phase extraction. Liquid-liquid extraction.Apart from my scientific background, I've also had experience founding my own company and managing a small team of researchers to achieve a common goal.
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Co-FounderMithridates TherapeuticsBangkok, Th -
In Vivo Pharmacology & Bioanalytical Assay DevelopmentHarvard Medical School Jul 2022 - PresentBoston, Ma, Us• Optimization of animal models for Duchenne Muscular Dystrophy to test the efficacy/safety of a novel protein therapeutic.• Development of bioanalytical assays (ELISA, mass spectrometry) for quantitation of a novel protein drug in pharmacokinetic / pharmacodynamic studies. -
Postdoctoral Research FellowDana-Farber Cancer Institute Jul 2022 - PresentBoston, Ma, Us• Optimization of animal models for Duchenne Muscular Dystrophy to test the efficacy/safety of a novel protein therapeutic.• Development of bioanalytical assays (ELISA, mass spectrometry) for quantitation of a novel protein drug in pharmacokinetic / pharmacodynamic studies. -
Research FellowNational University Of Singapore Apr 2021 - Jun 2022Singapore, Sg• Developed an efficient peptidomics and glycoproteomics workflow for identification of novel plasma/platelet biomarkers of acute coronary syndrome. • Development of a microalgae-based air purifier. Microalgae extraction and analysis. -
Co-FounderEtbio May 2019 - Aug 2020Singapore, Singapore, Sg• Development of a microalgae-based air purifier and algae extraction technology for large-scale ambient air CO2 removal.• Raised pre-seed investment.• Acquired 7 Letters-of-intent from customers and partner companies for trial and purchase of our device. -
ConsultantFreelance Jan 2017 - Aug 2020• Personally developed (or advised on the development of) bioanalytical quantitation assays for peptides/proteins, small molecule drugs and their metabolites.
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Founder-In-ResidenceEntrepreneur First Jul 2018 - Jul 2019London, Gb -
Phd Student/Research Fellow (Kini Lab / Mark Chan Lab/Spin-Off Company)National University Of Singapore Aug 2012 - Jul 2018Singapore, Sg• Designed and performed preclinical in-vivo models (rats, mice, pigs) to study the efficacy and safety of novel anticoagulant peptides derived from snake venom and tick saliva. Data acquired was used for fundraising activities with venture capital firms and liaising with CROs for ADME-tox and Phase I studies.• Initiated fundraising activities with venture capital firms and liaised with CROs for ADME-tox and Phase I studies.• Developed bioanalytical assays (LC-SRM, enzyme-based) and performed in-vivo animal pharmacokinetic studies for the anticoagulant peptides in rats and pigs. • Engineered a Plexiglas perfusion chamber for the porcine ex-vivo stent thrombosis model, without prior knowledge of engineering/design technology (I had to self-learn everything!). This perfusion chamber is now being used for Phase 0 clinical studies of our anticoagulant peptide.• Wrote and amended IACUC protocols and liaised with the animal use committee to obtain protocol approvals. • Managed a team of 3 research assistants for animal surgery procedures. -
Msc Student (Krause Lab)University Of Toronto May 2009 - May 2012Toronto, Ontario, CaIdentification of ligands for the orphan nuclear receptor PPARy (a target for many Type II Diabetes drug) from transgenic zebrafish:- Development/optimization of a protein purification protocol of a tagged-PPARy receptor fusion protein transgenically expressed in zebrafish embryos.- Optimization of a mass spectrometry method for identification of the endogenous ligand. -
Junior Research AssistantUniversity Of Toronto Sep 2008 - May 2009Toronto, Ontario, CaDevelopment of an antibody targeting the cadherin domain of the drosophila melanogaster Cad88c protein.- Molecular cloning of the sequence encoding for cad88c antigen region into an expression vector- Heterologous expression of the Cad88c antigenic domain in E. coli- Protein purification of the expressed Cad88c antigenic domain -
Junior Research AssistantUniversity Of Toronto Sep 2007 - May 2008Toronto, Ontario, CaForward genetic screen to identify mutant Arabidopsis thaliana with resistance towards Pseudomonas syringae bacteria. -
Junior Research AssistantNational Nanotechnology Center (Thailand) May 2007 - Aug 2007Liposome-based encapsulation of asiaticoside
Norrapat Shih Education Details
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National University Of SingaporeAnalytical Chemistry -
Online Gmp TrainingGood Laboratory Practice Certificate (Glp Nonclinical) -
Singapore-Mit Alliance For Research And Technology - Innovation Fellow ProgramEntrepreneurial And Small Business Operations -
University Of TorontoBiochemistry And Molecular Biology -
University Of TorontoDevelopmental Biology And Embryology -
Bangkok Patana SchoolHigh School Diploma -
University Of Toronto
Frequently Asked Questions about Norrapat Shih
What company does Norrapat Shih work for?
Norrapat Shih works for Mithridates Therapeutics
What is Norrapat Shih's role at the current company?
Norrapat Shih's current role is Co-Founder.
What is Norrapat Shih's email address?
Norrapat Shih's email address is no****@****ail.com
What schools did Norrapat Shih attend?
Norrapat Shih attended National University Of Singapore, Online Gmp Training, Singapore-Mit Alliance For Research And Technology - Innovation Fellow Program, University Of Toronto, University Of Toronto, Bangkok Patana School, University Of Toronto.
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