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My laboratory (slavovlab.net) aims to understand the rules governing emergent systems-level behavior and to use these rules to rationally engineer biological systems. We make quantitative measurements, often at the single-cell level, to test different conceptual frameworks and discriminate among different classes of models. Areas of focus include:• Ribosome mediated translational regulation: Mechanisms by which ribosomal modifications regulate protein synthesis • Single-cell protein analysis: We develop and apply mass-spectrometry methods that allow analyzing thousands of proteins in single cells. These data have enabled characterizing post-transcriptional regulation in single cells at systems level, as well as discovering macrophage polarization in the absence of polarizing cytokines.Background I received a BS from MIT in 2004 and then pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. As a postdoc in the van Oudenaarden laboratory at MIT, I characterized trade-offs of aerobic glycolysis (also known as Warburg effect) and obtained direct evidence for differential stoichiometry among core ribosomal proteins, suggesting that specialized ribosomes regulate protein synthesis.
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ProfessorNortheastern UniversityCambridge, Ma, Us
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ProfessorNortheastern University 2024 - PresentBoston, Ma, Us
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Associate ProfessorNortheastern University Jun 2021 - 2024Boston, Ma, Us
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Assistant ProfessorNortheastern University Sep 2015 - Jun 2021Boston, Ma, UsThe Slavov laboratory develops methods for high-throughput Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS and SCoPE2) and used them to quantify and understand protein networks that regulate cell fate and differentiation.
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Founding DirectorParallel Squared Technology Institute Feb 2023 - Present -
AffiliateBroad Institute 2015 - Oct 2017Cambridge, Ma, Us -
ScientistHarvard University Jan 2014 - Aug 2015Cambridge, Massachusetts, Us -
Postdoctoral ResearcherMassachusetts Institute Of Technology (Mit) Feb 2011 - Dec 2013Cambridge, Ma, UsSelected Primary Research Articles: http://www.cell.com/cell-reports/abstract/S2211-1247(14)00254-Xhttp://pubs.acs.org/doi/abs/10.1021/cn300218dhttp://www.molbiolcell.org/content/23/10/1986.full -
Postdoctoral ResearcherPrinceton University Jun 2010 - Jan 2011Princeton, Nj, UsSelected Primary Research Articles: http://www.molbiolcell.org/content/24/2/157.fullhttp://www.pnas.org/content/108/47/19090.fullhttp://www.molbiolcell.org/content/22/12/1997.full
Nikolai Slavov Skills
Nikolai Slavov Education Details
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Princeton UniversityCoordination Of Growth-Rate With Metabolism And Gene Expression -
Massachusetts Institute Of TechnologyMolecular Biology
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Harvard Medical School
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University College DublinSystems Biology
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Princeton UniversityMolecular Biology
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Sofia University St. Kliment OhridskiMolecular Biology
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Pmg
Frequently Asked Questions about Nikolai Slavov
What company does Nikolai Slavov work for?
Nikolai Slavov works for Northeastern University
What is Nikolai Slavov's role at the current company?
Nikolai Slavov's current role is Professor.
What is Nikolai Slavov's email address?
Nikolai Slavov's email address is n.****@****ern.edu
What is Nikolai Slavov's direct phone number?
Nikolai Slavov's direct phone number is +161737*****
What schools did Nikolai Slavov attend?
Nikolai Slavov attended Princeton University, Massachusetts Institute Of Technology, Harvard Medical School, University College Dublin, Princeton University, Sofia University St. Kliment Ohridski, Pmg.
What are some of Nikolai Slavov's interests?
Nikolai Slavov has interest in Science And Outdoors, Politics, Education, Environment, Health.
What skills is Nikolai Slavov known for?
Nikolai Slavov has skills like Cell, Molecular Biology, Computational Biology, Bioinformatics, Data Analysis, Microscopy, Matlab, Statistics, Molecular Cloning, Proteomics, Latex, Machine Learning.
Who are Nikolai Slavov's colleagues?
Nikolai Slavov's colleagues are Enid Franco-Zabala, Elizabeth Chilvers, Daniel Rachev, Srushti P., Mithali Manjunath, Magda H. Barecka, Akram Bayat.
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