Oleg Borbulevych

Oleg Borbulevych Email and Phone Number

Staff Scientist @ QuantumBio Inc.
Oleg Borbulevych's Location
State College, Pennsylvania, United States, United States
Oleg Borbulevych's Contact Details

Oleg Borbulevych work email

Oleg Borbulevych personal email

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About Oleg Borbulevych

Highlights: * Out-of-the-box thinking scientist with 20 years of work experience including 10 years in industry.* Ph.D. in Crystallography/Computational Chemistry.* Published over 90 research articles in international peer-reviewed journals. * Excelled in advancing multiple discovery projects leveraging a rare combination of professional skills in crystallography, computational chemistry and programming.* Strong creativity and problem solving skills. * Created XModeScore - the novel method (U.S. patent # 10,614,909) of accurate determination of protonation/tautomer states (Borbulevych et al., Acta Cryst., 2016, D72, 586) - that generates a six-figure revenue.* Engineered cutting edge technologies for the X-ray protein QM refinement (Borbulevych et al., Acta Cryst., 2014, D70, 1233) and ONIOM QM/MM refinement (Borbulevych et al, Acta Cryst, 2018, D74, 1063) that dramatically improve the crystal structure quality.Major Professional Skills: * Protein crystallography - all aspects * Cryo-EM refinement* Expert knowledge of protein refinement and pitfalls of traditional ligand treatment and fitting * Small molecule crystallography * Computational methods - molecular dynamics, protein docking, QM calculations, QSAR, Pipeline Pilot* Machine Learning (ML)* Statistical analysis, bioinformatics* Excellent programming skills (C++, Python, R, Perl, VBA) * Professional Software Development - NetBeans IDE, GitHub, Jenkins Platform* Stock Trading , Development of Strategies for Swing and Position Trading, OptionsSpecialties: * Crystallographer* Computational Chemist* Programmer * Software Developer

Oleg Borbulevych's Current Company Details
QuantumBio Inc.

Quantumbio Inc.

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Staff Scientist
Oleg Borbulevych Work Experience Details
  • Quantumbio Inc.
    Staff Scientist
    Quantumbio Inc. Feb 2011 - Present
    State College, Pa, Us
    * Originated advanced algorithms for the ligand conformational search and protein – ligand free energy calculations based on the novel Movable Type (MT) statistical mechanics method on a par with FEP.* Applied Machine Learning to predict ligand binding modes.* Created XModeScore - the novel method (U.S. patent # 10,614,909) of accurate determination of protonation/tautomer states based on the QM refinement (Borbulevych et al., Acta Cryst., 2016, D72, 586) * Advanced the cutting edge technology for the X-ray macromolecular refinement (Borbulevych et al., Acta Cryst., 2014, D70, 1233).* Pioneered advanced methods of the solvent treatment for protein simulations based on combination of the RISM model and X-ray crystallography data *Designed multi-step automated workflows for ligand and structure processing, refinement and post refinement QM calculations
  • University Of Notre Dame
    Professional Faculty
    University Of Notre Dame Dec 2003 - Jan 2011
    Notre Dame, In, Us
    * Served as a key X-ray crystallographer in structural studies of protein-protein complexes – class I pMHC and T-cell receptors (TCR).* Discovered the novel mechanism for pMHC/TCR interactions – the study highlighted in Nature Medicine (2010, 16, p.174).* Gained critical insights into molecular dynamics and mobility of over 20 pMHC /TCR complexes using molecular dynamics computational methods* Devised the new principles for the structure-based design of epitope cancer vaccines.* Shed light on methicillin-resistant Staphylococcus aureus (MRSA) long standing problem in Medicinal Chemistry by solving the crystal structures of various antibiotics bound to the signaling protein BlaR1. * Illuminated the structural mechanism of action of beta-lactamase enzymes.
  • Medical University Of Ohio
    Postdoctoral Fellow
    Medical University Of Ohio Mar 2002 - Nov 2003
    Us

Oleg Borbulevych Skills

Protein Chemistry Drug Design Molecular Dynamics Nmr Computational Chemistry Structural Biology Biophysics Medicinal Chemistry Biochemistry X Ray Crystallography Molecular Modeling Crystallography Life Sciences Drug Discovery Chemistry Molecular Biology Quantum Chemistry Qsar Python Docking C++ Perl Vba

Oleg Borbulevych Education Details

  • New Mexico Highlands University, Las Vegas, Nm
    New Mexico Highlands University, Las Vegas, Nm
    Chemistry

Frequently Asked Questions about Oleg Borbulevych

What company does Oleg Borbulevych work for?

Oleg Borbulevych works for Quantumbio Inc.

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Oleg Borbulevych's current role is Staff Scientist.

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Oleg Borbulevych attended New Mexico Highlands University, Las Vegas, Nm.

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Oleg Borbulevych has skills like Protein Chemistry, Drug Design, Molecular Dynamics, Nmr, Computational Chemistry, Structural Biology, Biophysics, Medicinal Chemistry, Biochemistry, X Ray Crystallography, Molecular Modeling, Crystallography.

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