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Highlights: * Out-of-the-box thinking scientist with 20 years of work experience including 10 years in industry.* Ph.D. in Crystallography/Computational Chemistry.* Published over 90 research articles in international peer-reviewed journals. * Excelled in advancing multiple discovery projects leveraging a rare combination of professional skills in crystallography, computational chemistry and programming.* Strong creativity and problem solving skills. * Created XModeScore - the novel method (U.S. patent # 10,614,909) of accurate determination of protonation/tautomer states (Borbulevych et al., Acta Cryst., 2016, D72, 586) - that generates a six-figure revenue.* Engineered cutting edge technologies for the X-ray protein QM refinement (Borbulevych et al., Acta Cryst., 2014, D70, 1233) and ONIOM QM/MM refinement (Borbulevych et al, Acta Cryst, 2018, D74, 1063) that dramatically improve the crystal structure quality.Major Professional Skills: * Protein crystallography - all aspects * Cryo-EM refinement* Expert knowledge of protein refinement and pitfalls of traditional ligand treatment and fitting * Small molecule crystallography * Computational methods - molecular dynamics, protein docking, QM calculations, QSAR, Pipeline Pilot* Machine Learning (ML)* Statistical analysis, bioinformatics* Excellent programming skills (C++, Python, R, Perl, VBA) * Professional Software Development - NetBeans IDE, GitHub, Jenkins Platform* Stock Trading , Development of Strategies for Swing and Position Trading, OptionsSpecialties: * Crystallographer* Computational Chemist* Programmer * Software Developer
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Staff ScientistQuantumbio Inc. Feb 2011 - PresentState College, Pa, Us* Originated advanced algorithms for the ligand conformational search and protein – ligand free energy calculations based on the novel Movable Type (MT) statistical mechanics method on a par with FEP.* Applied Machine Learning to predict ligand binding modes.* Created XModeScore - the novel method (U.S. patent # 10,614,909) of accurate determination of protonation/tautomer states based on the QM refinement (Borbulevych et al., Acta Cryst., 2016, D72, 586) * Advanced the cutting edge technology for the X-ray macromolecular refinement (Borbulevych et al., Acta Cryst., 2014, D70, 1233).* Pioneered advanced methods of the solvent treatment for protein simulations based on combination of the RISM model and X-ray crystallography data *Designed multi-step automated workflows for ligand and structure processing, refinement and post refinement QM calculations -
Professional FacultyUniversity Of Notre Dame Dec 2003 - Jan 2011Notre Dame, In, Us* Served as a key X-ray crystallographer in structural studies of protein-protein complexes – class I pMHC and T-cell receptors (TCR).* Discovered the novel mechanism for pMHC/TCR interactions – the study highlighted in Nature Medicine (2010, 16, p.174).* Gained critical insights into molecular dynamics and mobility of over 20 pMHC /TCR complexes using molecular dynamics computational methods* Devised the new principles for the structure-based design of epitope cancer vaccines.* Shed light on methicillin-resistant Staphylococcus aureus (MRSA) long standing problem in Medicinal Chemistry by solving the crystal structures of various antibiotics bound to the signaling protein BlaR1. * Illuminated the structural mechanism of action of beta-lactamase enzymes. -
Postdoctoral FellowMedical University Of Ohio Mar 2002 - Nov 2003Us
Oleg Borbulevych Skills
Oleg Borbulevych Education Details
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New Mexico Highlands University, Las Vegas, NmChemistry
Frequently Asked Questions about Oleg Borbulevych
What company does Oleg Borbulevych work for?
Oleg Borbulevych works for Quantumbio Inc.
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Oleg Borbulevych's current role is Staff Scientist.
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Oleg Borbulevych attended New Mexico Highlands University, Las Vegas, Nm.
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What skills is Oleg Borbulevych known for?
Oleg Borbulevych has skills like Protein Chemistry, Drug Design, Molecular Dynamics, Nmr, Computational Chemistry, Structural Biology, Biophysics, Medicinal Chemistry, Biochemistry, X Ray Crystallography, Molecular Modeling, Crystallography.
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