Oscar Cabrera Email & Phone Number

Somerville, Ma, Us

• Supervised and performed functional studies to generate CAR-T cells (eg. ex vivo and same-day) using Tessera’s gene writer platform (via non-viral gene delivery)• Led cross-functional team efforts with research and CMC to nominate gene writing critical components for potential DC nomination of Tessera’s CAR-T program.• Led a T cell/PBMC cell core operations group of 4 people involved in primary cell banking and donor registration/assessment for suppling frozen cell material across multiple research groups in the organization.

• Lead contributor to the current and next generation of ATLAS screening platform, utilizing various techniques including cell sorting, multicolor flow-cytometry, and high-throughput screening assays.• Troubleshot and developed improved workflows applicable for research and clinical development.• Ensured scientific integrity and documentation of experimental data to meet standards suitable for intellectual property and FDA submissions

Brentford, Middlesex, Gb

• Key contributor in investigating the biology of novel targets and evaluate the effects of newly developed drug lead candidates in autoimmune disorders (eg. SLE, RA, sarcoidosis).• Designed and performed experiments using cell and molecular techniques suitable for drug target identification and validation.• Generated and presented scientific findings at various meetings to partners/collaborators and collaboratively planned experimental paths moving forward.

Wakefield, Massachusetts, Us

• Key contributor in generating new CRISPR-based assays for enhancing biomarker and early cancer detection discovery using NGS and GR’s Negative Enrichment platform.• Validated target-based enrichment in both genomic and cfDNA using next-gen sequencing and qPCR.• Designed sgRNA and PCR primers / qPCR probes for CRISPR-based targeted enrichment. • Planned and carried out proof-of-concept experiments for developing targeted enrichment kits.

North Chicago, Illinois, Us

• Worked cross-functionally with our functional genomics team to screen and validate novel therapeutic targets for the treatment of autoimmune disorders and chronic inflammation.• Supported target validation group by generating CRISPR mutations using both mammalian cell lines and primary immune cells.Managed one associate scientist to develop standard operating procedures (SOPs) for establishing a lentiviral core facility at the AbbVie Cambridge site.• Generated study reports and maintained a detailed record of experiments in electronic lab notebooks in accordance with company policy.

Worcester, Ma, Us

• Prepared and designed course materials such as syllabus, homework assignments and tests• Delivered lectures to undergraduate students on the medical and biological implication of microorganisms such as prokaryotes, eukaryotes and viruses.• Facilitated classroom discussions• Maintained regularly scheduled office hours to advise and assist students.• Courses taught: BI204 – Microbiology (Student Approval Rating – 4.5 on 5 point scale) and BI206 – Medical Microbiology (Student Approval Rating – 3.9 on 5 point scale)

Worcester, Ma, Us

• Generated a fluorescent oncogenic Hedgehog reporter cell line to perform a small molecule screen looking for ciliary inhibitors in basal cell carcinoma (a Hedgehog-derived cancer). This work led to the identification of two potential inhibitors that inhibit basal cell carcinoma in a Smo-dependent manner. • Developed an arrayed CRISPR screen using a ciliary Hedgehog reporter cell line to identify novel genes involved in primary cilium-dependent Hedgehog signaling using high-content confocal microscopy. • Advised two junior post-doctoral associates; established multicenter collaboration with other universities for drug screening; supervised the research projects of one graduate rotation student and two undergraduate summer students.

Tallahassee, Fl, Us

• Developed and executed a proteomic-based approach to identify proteins required for acentrosomal cell division in Drosophila. This work led to the identification of proteins involved oxidative stress, which led us to understand the role for centrosomal proteins involved in cell homeostasis during autophagy.• Executed a forward genetics screen looking for genes required during centrosome loss. This work led to identification of proteins involved in acentrosomal mitosis.

Miami, Fl, Us

Project: Studied how methylation of histone H3K56 affects the chromatin remodeling complex SWI/SNF during Nucleotide Excision Repair in Saccharomyces cerevisiae.Responsibilities: Worked under supervision of research associate to isolate chromatin and immunoprecipitate the SWI/SNF complex for H3K56 methylation. Methodologies: Chromatin immunoprecipitation (ChIP), yeast cell culture.

Miami, Fl, Us

Determined whether gap junction proteins in invertebrates (innexins) form ion channels or receptor through glycosylation.

Ph.D., Biomedical Sciences

B.S., Biochemistry And Molecular Biology

Other; Hmx Fundamentals/Pro Online Certificate Program – Immunology