Eric Chan Email & Phone Number

New York, NY, US

Miami, Florida, US

Pennington, New Jersey, US

- Led a team of 5 scientists & engineers to develop and implement scalable high-yielding processes using novel technologies for the production of plasmid DNA and viral vectors, related new modalities to support early and late-stage gene therapy programs. - Responsible for tech transfer processes from China to the US production site. Supporting US site.

US

- Led a team of scientists in optimizing AAV triple transfection processes (DoE/Qbd approach) to support IND filings and GMP production campaigns. Leading tech transfer efforts in authoring & reviewing development, process description, facility fit reports, BOM, master batch record. Collaborating with the manufacturing team on MCB generation, Veeva systems.

Global, Global, OO

- Built technical credibility for the Cytiva Cell Culture business by providing scientific and strategic support of upstream customers for cell culture products and new services offerings.- Worked with the commercial team through a specific territory plan to find Cytiva Cell Culture media business opportunities and provided innovative solutions to meet.

Lawrence Township, NJ, US

- Led a team of two scientists in early stage bispecific antibodies (BsAbs) process development, tasks include but not limited to initial platform fit exercise, media/feeds screening, RCBs clone selection, clone stability studies(Ambr15), high throughput process development runs (Ambr250 & 3L bioreactors), process lock, confirmation, tox material.

Lawrence Township, NJ, US

Waltham, MA, US

- Supported BLA filing of Felzartamab, upstream PD team lead on scale down model qualification and acceptance criteria establishment (equivalence tests, 3SD & tolerance interval approach). Led the upstream PD process characterization efforts with statistician, MSAT, manufacturing & cross functional CMC teams to conduct PHA, SDMQ, DoE, FMEA, risk.

杭州, 浙江省, CN

- Responsible to generate research grade reagents (antibodies, Fc-fusion proteins, enzymes, cytokines and etc.) to support discovery programs in house, leading a group of junior scientists to oversee wide range of bioprocess operations from cloning, expression, purification and basic analytical testing.- Successfully developed a semi-high throughput.

Waltham, Massachusetts, US

- Led the upstream PD effort on biosimilar tuning of Ustekinumab by alternating process parameters & media formulation/supplements to match the approved originator’s quality profile (N glycans & PTMs). Over 100 perfusion runs were executed with 95%+ success rate, the process was successfully transferred to GMP production site and received EMA approval in.

Melbourne, VIC, AU

- Responsible for managing CMOs and CROs for bio-analytical methods establishment and testing of human Mesenchymal Stem cells (MSCs) in 2D cell culture environment. Task includes analytical assay development/transfer/validation to support BLA filing.- Worked closely with QA & project management to support in process GMP sample testing, QC lot release.

Indianapolis, Indiana, US

- SME in molecular cloning and protein expression, cloned ~500 constructs a year to support company's pipelines. Enhanced protein/antibody expression level by manipulating promoters, leader signal sequences and codon optimization.- Developed semi-automated high through-put antibody cloning platform using In-fusion homologous recombination technology, which.

Indianapolis, Indiana, US

- Responsible for performing cells based ADCC, CDC and ELISA based binding assays to support all stages of therapeutic antibody development. Optimized Fc effector function ADCC NFAT reporter gene bioassays to establish a new system suitability using anti CD20 Rituxanmab and CD20 expressing Wil2-S line to improve assay range, linearity and LLOQ..

Farmingdale, NY, US

- Developed novel fluorescent cell assays in flow cytometry (FACS), fluorescent microscopy and 96/384 wells plate cell-based platform for high-throughput drug screening that offer a superior assay signal window, improved lower detection limit, higher specificity, higher Z’-score and low intra/inter-plate CVs than traditional commercial assays.- Developed.

Morris Plains, New Jersey, US

- Developed processes using bench scale and GMP pilot scale bioreactors (Stainless steel) to produce therapeutic antibodies. Responsible for bioreactor operations such as assembling, SIP, CIP, pressure testing, buffer prep, seed train expansion & troubleshooting.- Delivered high yielding stable mammalian cell lines for production of monoclonal antibodies..

New York, NY, US

- Designed primers to clone over 50 proteins screened from yeast-2-hybrid system into Flag/GFP tagged vectors for the study of protein-protein interaction.- Confirmed protein interactions fished from yeast-2-hybrid by Co-transfection of two fusion proteins into HEK293 cells. Analyzed interactions by Co-IP, SDS-PAGE and western blot.- Cultured Myoblast.

- Conducted fieldwork to obtain soil and air samples in the city.- Involved in testing of the samples and writing environmental assessment report.