Howard Parker Email & Phone Number

Northwich, Gb

Cheshire East, England, United Kingdom

Co-founder and CSO of UltraPlex Bioanalysis Ltd, providing specialist biomarker research, identification and quantification. Specialist in protein chemistry, immunoassay and biomarkers.

Cheshire

Bioanalytical project leader with main focus on immunoassays for PK, PD and immunogenicity. Broad experience with a number of platforms and technologies, and strong track record in project delivery.

Fordham

Development of new assays for clinical research projects including PK, biomarker and ADA studies. I have taken a lead role on many ongoing projects, regularly giving suggestions and advice where needed and producing robust, quality data to tight deadlines. I perform critical reagent management, assay re-establishment and validation (PK and ADA) as well as assay troubleshooting and project manager / sponsor interaction. I have a great deal of experience with a number of platforms including ELISA, ECLIA (MSD), bead luminescence (Luminex), AlphaScreen and FRET/HTRF.

ICP-MS analysis of soil, water and leachate samples. ISO 14001 compliance, CHAS accreditation, environment, health and safety.

Cambridge, United Kingdom

In vivo specialist within CVMD, working on diabetes, obesity and chronic kidney disease. Currently building models of 5/6 nephrectomy and implantation of cardiac telemetry, incorporating real-time glucose measurements.

Mölndal

Providing in vitro support to novel iMED RIA projects, validating targets and exploring new pathways to treat respiratory inflammation and asthma. Primary assays include immunoassays (MSD, ELISA, Luminex), RT-PCR, Western blot and FRET, with additional mediator analysis as needed.

Göteborg, Sverige

Staff Scientist within the Cardiovascular and Metabolic Research Laboratories, working with Pr. Jan Boren and Dr Malin Levin. In vitro and in vivo research, focussing on cardiac lipid metabolism.Current role includes RT-PCR, ex vivo cardiac metabolism and glucose / insulin / beta oxidation studies in vivo. Most recently I have been devloping a model of cardiac pressure overload, using transaortic constriction model in mice.

Core member of Animal Physiology Team, providing in vivo support to Genes and Metabolism section of the CSC.Key role is to establish phenotypes in transgenic and congenic rodent strains using a broad range of physiological and pharmacological techniques. Central to this is the generation of chronic and acute models, integrating cardiac imaging (ultrasound, PET/CT, MRI), metabolic studies and haemodynamics.In addition to providing solid in vivo support I run several in vitro models including Langendorff isolated perfused heart and production of native cell preparations.I also function as a training resource for Imperial College and MRC staff and students, having given lectures and first hand demonstrations of various techniques.

Research assistant in cardiology group. We are a cutting edge cardiac imaging group using magnetic resonance and positron emission tomography techniques to obtain non-invasive images of the beating heart. Main roles and responsibilities include:In vitro biochemical and molecular biology techniques including Western Blot, RT-PCR, enzyme and receptor pharmacology assays including ELISA, EIA and radioligand binding, protein sequencingIn vivo pharmacology and physiology experiments including conscious and anaesthetised modelsIn vitro pharmacology and phsiology experiments using isolated tissues and organsNon invasive imaging using ultrasound, PET/CT and MR in models of heart failure and diabetes. Other imaging modalities include echoMRI and bioluminescence.Image registration, segmentation and analysis and statistical interpretation of dataCommunication of data and results in written and oral forms

Senior research scientist with background in cardiovascular disease and obesity. Latterly some biomarker research. Main roles and responsibilities include:In vivo preclinical pharmacology and physiology experiments in rodent and canine models of diseaseBroad range of in vitro techniques including Western Blot, RT-PCR, enzyme and receptor pharmacology assays including ELISA, EIA and radioligand binding, protein sequencingSupervision of junior scientistsStatistical analysis of dataOral and written presentation of dataProject management and assignation of resourceCollaboration with external research groups

Project manager for a obesity / diabetes drug approach, led preclinical proof of mechanism studies.Biomarker specialist for several projects including obesity, diabetes and respiratory diseases.Immunology specialist for Infectious Diseases therapeutic area.

Responsibilities included Day to day laboratory and classroom maintenance, management of departmental accounts, equipment and sundries, curricular support for A-level and GCSE students.

Bsc Hons, Applied Biology

Carried out as part time day release study

Hnc Applied Biology

part time day release

Education record