Patricia C. Email and Phone Number

Pathology and Analytical Laboratory

Responsible for establishment, validation and conduct of in vitro metabolism studies including metabolic stability, metabolite profiling and enzyme inhibition in cryopreserved hepatocytes and sub-cellular fractions. Bioanalysis of samples from in vitro metabolism and in vivo toxicokinetic studies using LC-MS, LC MS/MS and HPLC-UV. Bioanalytical method development and validationStudy Director working within requirements of GLP

Responsible for establishment, validation and conduct of in vitro and in vivo genetic toxicology studies: rodent micronucleus, mammalian chromosome aberration, mouse lymphoma mutation and bacterial reverse mutation.Customer liaison to establish and deliver required studies within agreed time frame Day to day management of a small team of study directors and technicians; scheduling workloads, conducting performance reviews, recruiting staff, organising training, maintaining safe working environmentConduct and validation of a variety of other in vitro techniques including ELISA and cytotoxicity assays (e.g. Mattek EpiDerm™, EpiOcular™).Study Director working within requirements of GLP

Performance of in vitro genetic toxicology studies: CHO chromosome aberration and point mutation.

Performing chemical and physical analysis of cigarettes and combustion products and, subsequently, in vitro genetic toxicology studies.