Patrick Collins Email & Phone Number

Millbrae, CA, US

Sunnyvale, California, US

• Created and evolved therapeutics strategy as a member of the discovery leadership team
• Pitched immunology and inflammation assets and capabilities to VCs and companies for a potential spinout
• Worked closely with statistical geneticists and epidemiologists to identify therapeutic opportunities and patient population(s) likely to benefit based on the incomparable 23andMe database

Sunnyvale, California, US

• Developed strategy and built capabilities for applying functional genomics to genetics-informed targets internally and in collaboration with GSK
• Built and developed a highly collaborative and effective team from 0 to 11 team members
• Co-led ophthalmology, hearing loss, rare disease and opportunistic target discovery with GSK
• Co-chaired the Joint Research Committee for discovery stage programs with GSK

• Molecular Engineering group leader, Genome Analysis Unit
• Performed and directed positive and negative selection pooled CRISPRko, CRISPRi, CRISPRa and shRNA screens for target identification and mechanism of action/resistance studies
• Developed and implemented a cloning pipeline, reagents and assays for validation of novel T-cell receptors for TCR-T therapeutic candidates
• Supported siRNA therapeutic development with trigger selection, candidate screening and mechanism of action studies
• Investigated transcriptional and post-translational regulation solutions for cell and gene therapies
• Managed viral vector (AAV, LV and HSV) optimization and production

• Target ID & Validation, Genome Analysis Unit
• Performed and directed high-throughput, arrayed, cell-based screens for metabolic, inflammation, neuroscience and oncology target and biomarker discovery
• Assembled, annotated and maintained an arrayed, cDNA library for overexpression screens

• Develop new promoter and 3’ UTR reporter products
• Generate data for marketing literature and product support
• Direct sub-cloning of 10,000 reporter clones into a lentiviral vector for a joint venture with Sigma-Aldrich

• Performed and analyzed high-throughput, cell-based promoter and 3’ UTR reporter assays as a functional genomics service for academic and pharma customers
• Implemented a high-throughput site-directed mutagenesis pipeline for functional validation of transcription factor binding site predictions in cell-based reporter assays
• Managed collaborations with academic labs as part of NHGRI’s ENCODE project

Waltham, MA, US

• Led the development of the AmpFlSTR® Identifiler™ PCR Kit, used for human identity and parentage
• Performed test site installs and manage collaborations with federal, state and private crime laboratories
• Maintained development documentation for ISO 9001 compliance

Ph.D., Genetics

B.A., Biology, Classical Studies