Patrick Farrell Email & Phone Number

Calgary, Ab, Ca

Specializing in early-stage biologics development and strategic oversight for vaccine and therapeutic products, interim leadership, CMC regulatory support, technology transfer and outsourcing, due diligence, and technical writing.Expertise is based on 20+ years experience leading research and development teams in both small biotech and large biopharma organizations. Progressed over a dozen vaccines and therapeutics into Phase 1 and 2.• As VP of mRNA-LNP Vaccine Process & Analytical Development, led teams responsible for production of plasmids, mRNA, cationic lipids, LNPs, analytical packages, DS and DP GMP manufacturing, QC and stability testing of mRNA-LNP vaccine candidates for infectious diseases and cancer.• As Head of Global Bioprocess Technology, CMC leader for the advancement of novel subunit vaccines for influenza and led corporate initiatives related to biomanufacturing, expression technologies, and new vaccine approaches including mRNA.• As Global Director for Upstream Bioprocess Development, responsible for GMP manufacturing processes for cell banking, viral seeds, and drug substances for approximately 20 live viral, subunits, and mAb candidates produced from animal and microbial cultures.• As Head of Research and Development for immunodiagnostic devices, directed activities in proteomic discovery and moving disease-related biomarkers onto immunodiagnostic platforms. Targets included congestive heart failure, Alzheimer's, diabetes, traumatic brain injury, and influenza.

Calgary, Alberta, Ca

Lead talented teams of scientists and research associates responsible for all aspects of mRNA-LNP vaccine development and supply including: plasmid preparation, mRNA synthesis, lipid nanoparticle formulation, analytical development, QC and stability testing, large-scale GMP manufacturing by CMOs, process validation, analytical testing by CTLs, support of external partnerships, and preparation of regulatory submissions.

Paris, France, Fr

Led various corporate initiatives related to bioprocess and vaccine expression technologies CMC leader for new subunit vaccine approaches for influenza including technology transfers. Led a scientific team evaluating expression systems for subunit and mRNA vaccine manufacturing. Co-ordinated external collaborations related to technology development from small biotech and academic partners. Worked with Business Development and External R&D evaluating new acquisition and licensing opportunities.

Paris, France, Fr

Directed Upstream process development activities for a team of scientists and technologists related to live viral and subunit vaccines, and monoclonal antibody therapeutics. Antigen designs and expression system optimization. Responsible for GMP manufacturing processes for vaccine drug substances used in clinical trials from animal and microbial cultures, and cell banking and viral seeds. Co-ordinated external collaborations and large outsourced manufacturing projects. Member of Global Project Teams for various vaccine project CMC activities and regulatory submissions. Supported Industrial Operations for troubleshooting and improving licensed product manufacturing processes. Collaborated with academic institutions for strategic activities.

Directed research, development, and production activities related to discovering and moving potential disease-related biomarkers into commercial immunoassays.

Calgary, Alberta, Ca

Research Scholar sponsored by the Alberta Medical Foundation for Medical Research. And Associate Director of the Pharmaceutical Production Research Facility. Conducted independent research in the areas of therapeutic virus production from animal cells, DNA vaccines, applications of flow cytometry, high-throughput protein expression schemes, transfection, and recombinant virus generation.

Msc, Phd, & Post-Doc, Medical Science And Engineering

B.Eng, Bio/Chemical Engineering