Patrick L. Email & Phone Number

Molecular biologist with over 10 years of research experience working in gene therapy and diagnostic companies, specialized in Next Generation Sequencing (NGS), genomics, bioinformatics, and genome editing technologies.- Supervised a team of Ph.D. level scientist and research associates- Implemented unbiased genome-wide off-target assays (both in vivo and in vitro) and identified off-targets for internal and external programs- Serve as subject matter expert on gene editing specificity with external partners, FDA, and NIST- Developed various assays for difficult-to-sequence repeat expansion disease genes- Developed assays for somatic NGS panel testing of FFPE tumor tissues- Developed assays for splicing VUS resolution- Drafted SOPs and validation plans- Oversaw the NGS team to provide NGS service and bioinformatic support to research scientists- Established a tissue-specific ribosome-bound mRNA isolation method in Drosophila melanogaster- Identified dietary restriction-induced tissue-specific translation regulation- Uncovered the translation mechanism of mouse L1 retrotransposon- Identified L1 mRNA-binding cellular modulators of retrotransposition- Published over 20 peer-reviewed articles