Patrick Leung Email & Phone Number

Switzerland 🇨🇭 , Ch

San Carlos, California, Us

Defined the hardware architecture for the first commercial proteomic analysis platformand performed detailed designs for subassemblies from chassis, fluidic manifolds/liquidhandling modules, to flowcell and consumables designs. Supervised contract design firmson development such as electronic board designs, miniature robotic reagent sampler,and industrial design. Supported internal R&D fixture development and test activities.

Waltham, Ma, Us

Developed the mechanical architecture and perform detailed designs of the IVD-ready Genexus™ Integrated Sequencer and Purification System at multiple levels: chassis/skin, robotics/sample prep deck layout, thermal cycler, reagent chiller, thermal management, and consumables design. Handed off initial designs to junior designers and supervised for completion. Interacted with internal manufacturing infrastructure, external contract manufacturers/design house for design transfer and OEM production. Led different development/planning phases of Ion Chef robotic sample prep system. Designed liquid cooled PCR module, temperature controlled reagent trays, emulsion breaking centrifuge, as well as associated pipet tip and reagent cartridge assemblies. Architected overall air flow/thermal management. Created product specifications, DHF, and instrument design verification tests/reports. Provide overall instrument hardware guidance. Set up and manage external contract manufacturers and internal reagent manufacturing for consumable builds, including manufacturing spec definition, fixture designs, and investigating manufacturing related problems.Designed Ion OneTouch2 sample amplification/collection instrument for semiconductor DNA Sequencers. Transferred design to contract manufacturer and developed the final production test for the instrument. Supported product validation testing and production transfer phase activities. Provided engineering support for field-related issues. Led part cost-reduction activities and developed multiple OEM/in vitro diagnostic versions for sample prep instruments/PGM Sequencer platforms, which has completed the FDA listings for clinical use as a class II medical device.

San Diego, Ca, Us

Engaged in all development phases (from concept/feasibility study, development, to production transfer) of MiSeq® personal sequencing instrument platform. Tested early concepts and develop fluidics architecture for both the instrument and consumable sides. Specified component/system-level requirements and components. Developed and carried out validation test plans for fluidics subsystems. Supported production transfer phase activities.Designed, tested, and validated glass flowcells, optical test targets, and flowcell plastics consumables for MiSeq® final part qualification. Manage vendor interaction for technical development and final part qualification. Designed equipments for internal flowcell processing usage.Evaluated research projects for future platform development. Led all development efforts in flowcell holder design with gasket/manifolding and thermal control, system fluidics layout, vacuum chucking system, and coolant supply system for HiSeq® 2000 and 2500 high-throughput genome sequencing platform. Developed and carried out validation test plans for fluidics subsystems. Supported production transfer phase activities, including stage tip-tilt and other motion control systems.Provided sustaining engineering supports for existing Genome Analyzer® platform.

Designed, prototyped, and tested a chip-based microfluidic HPLC system (cHiLPC® nanoflex system) from component to system level. Developed a novel microfluidic interface for high pressure (over 6kpsi) liquid chromatography and mass spectrometry-electrospray (MS-ESI) applications. Developed and test pressure transducers using silicon strain gauges. Developed and tested a novel electro-kinetic flow control scheme. Designed and tested high pressure electro-pneumatic pumps. Designed and prototyped fast heating/cooling module for PCR-RT application.Conducted FMEA/design reviews and developed systems specs/design history file (including design verification/validation protocols, assembly and test procedures, part drawings, BOM, etc) for new chip-based HPLC systems and modules.Developed, prototyped and tested a novel, chip-based particle processing platform, which analyze a cardiac panel bead-based assay in a parallel format. Designed, prototyped, and evaluated microchips, hardware, and optical imaging systems with both off-axis and confocal illumination and fluorescent measurement configurations. Wrote software for nl/min flow control, image capture, and image processing.

Sunnyvale, Ca, Us

Designed and prototyped a low thermal mass heatsink, optimized the cooling control system in RT-PCR products with a 25% cooling time reduction; characterized an ultrasonic cell-lysing system with laser Doppler vibrometry and ultra-miniature pressure transducers; performed statistical analysis to experimental results.

Lisboa, Pt

Conducted opto-mechanical design reviews/DFM studies for the head-mounted display products for laparoscopic surgical use; assisted design engineers to select prototyping processes such as using aluminum injection molds, laser machining, and sheetmetal chemical-etching; set up in-house manufacturing facility to support pre-production builds; set up a documentation system, ISO compliance, and FDA/cGMP guidelines; evaluated, selected and interacted with contract manufacturers for scale-up production build.

Introduced four new product lines to production and managed over 100 complex hardware/software configurations for motor drive products; designed sheet metal packaging, heat sinks, plastic enclosures, and production fixtures; prototyped new plastic packages with SLA and urethane molding; conducted thermal analysis and tests; prepared ECOs and BOMs; acted as a Materials Review Board member.

Ms, Mechanical Engineering

Bs, Mechanical Engineering