Alder is now a Lundbeck company

Manager for analysts, including responsibility for two direct reports.Analytical lead on a late stage mAb commercial development project.Analytical lead on a project for integrating non-mAb molecules into the Amgen platform.

Analytical development, general process development support and some formulation work

Analytical development, general process development support and some formulation work

Protein chemist, HPLC separations action, lab baker.

High-throughput screening (HTS) of proteins using various methods, including: thermostabilization, differential static light scattering, differential scanning fluorimetry, HPLC- and activity-based assaysConstructed and maintained small molecule libraries (generic and family-specific)Developed and implemented activity assays for proteases, kinases, and lipasesIsothermal titration calorimetry binding studies of protein - ligand interactionsManaged Agilent ESI TOF LC/MS system: trained all users, performed specialized MS experiments such as non-denaturing ESI MS for ligand detection, analysis of peptides, small molecules and enzymatic reactionsProtein modification including reductive methylation (to aid in crystallization) and biotinylation (for generation of antibodies)CD spectroscopic analysis of proteins and protein - ligand complexesComputer database work for compound management and screening resultsHands-on instruction and seminars at protein screening workshops for external scientists

- Helped steer the Ontario Access Coalition though incorporation- Organized and coordinated the OACs annual Earth Day cleanup event in 2009 for over 100 volunteers. - Spearheaded online petition that garnered over 800 signatures to protest the suggested closure of the Niagara Glen bouldering area- Responsible for web site development and maintenance (currently remain the site administrator)

Characterized fast time-scale motion in proteins and protein complexes using solution NMR spectroscopy of 15N, 13C, and 2H labeled proteins and peptidesIsothermal titration calorimetry to study protein - peptide interactionsProtein and peptide expression and purification using HPLC, IEC, HIC and various affinity methodsExtensive computing experience including: NMR and structural biology programs; shell, Perl, and TCL/TK scripts; Linux, SGI and SUN system administration; MySQL database managementSupervised research technician for several years

Characterized a zinc finger protein that binds double-stranded RNA from discovery of the partial cDNA to characterization of the biochemical and developmental properties of the full-length proteinSupervised and trained graduate students in various tasks found in RNA laboratories including: RNA transcription and purification, protein expression and purification, frog embryology, and use of radioisotopes (32P, 35S)Teaching assistant for various courses including exam preparation and running study sessionsVolunteered at a Salt Lake City elementary school to supervise dissection of dogfish sharks and discussion of anatomy (volunteered two years

Expression and characterization of growth factors in tissue culture cells using radio-assaysManaged laboratory reagents and supplies, various molecular biology techniques (cloning, etc.) for producing growth factor proteins in tissue culture cellsTrained research technician in tissue culture and DNA manipulation techniques

Maintained laboratory reagents, prepared plasmid DNA, maintained tissue culture cells and isolated nuclei from cultured cellsTrained several laboratory assistants