Patrick Johnstone, Mba Email & Phone Number

Cambridge, Ma, Us

Cambridge, Ma, Us

Cambridge, Ma, Us

- Upstream engineer within the Manufacturing Sciences department responsible for developing and operating 5L and 15mL (ambr15) scale-down models of large-scale cell culture bioreactor processes, investigations and trouble-shooting of manufacturing deviations via small-scale experiment design to identify root cause, assisting in the technology transfers of processes entering our large-scale manufacturing facility, implementation and understanding of advanced process control technologies (e.g. capacitance probes), lab lead for cell culture perfusion technologies, and experienced in cell bank generation. - Recently completed a temperorary work assignment within the Tech Transfer group, successfully leading the upstream cell culture portion of two large-scale process transfers into our GMP manufacturing facility that produced drug substance for clinical trial re-supply by organizing and conducting large cross-functional weekly and ad-hoc meetings, maintaining and updating the process flow diagram that detailed the process controls for each unit operation, making real-time processing decisions to ensure product quality and manufacturing success, and communicating process trending updates and data analysis to internal groups and external partners.- Published in the Biotechnology Progress journal for my characterization of cell damage within a rotary lobe pump in a cell culture perfusion process. - Presented at the 2019 American Institute of Chemical Engineers (AIChE) Annual Meeting in Orlando, Fl on my investigation into capacitance driven process variation in large-scale manufacturing, as well as my characterization of cell culture damage via a rotary lobe pump in a large-scale N-1 seed perfusion process.

Cambridge, Ma, Us

- Led a cross-functional collaborative sub-team focused on re-developing a cell culture bioreactor process to increase per batch protein production output 3-fold while maintaining product quality that could ultimately lead to millions of dollars in additional annual revenue.- Supported technology transfers by conducting laboratory experiments, analyzing process trends across multiple data systems, and providing decisions for manufacturing implementation based on technical expertise.- Designed and independently conducted upstream cell culture small-scale bioreactor and shake flask studies to support process development and robustness, media and vendor qualification, and scale-down model development and improvement that helped ensure continuity to our drug substance supply.- Mentored and trained new lab associates, creating a manual that provided insights on how to effectively plan and conduct lab experiments, aseptic handling techniques, and uses of upstream lab equipment while setting expectations and providing support.

Cambridge, Ma, Us

- Biogen is an international biotechnology company, driven to bring innovative and high-quality treatments for neurological diseases to patients via world-class science, technology, and engineering. - Upstream associate scientist responsible for operating and understanding 5L scale-down bioreactor models of large-scale cell bioreactor processes. - Assisted in supply chain improvement projects by conducting raw material and vendor qualification studies at lab scale that was able to extend the shelf-life of complex, chemically defined media powders out to 2+ years.- Assisted in the technology transfers of processes into our facility by conducting satellite bioreactor studies and generating cell banks for stability testing.

Sant Cugat Del Vallès, Barcelona, Es

Responsible for generation and analysis of Engineering Test Plan for process yield improvements performed at manufacturing scale. Analyzed data from previous years to spot trends and suggested process improvements. Assisted on bench scale studies and bioanalytics testing.

Chicago, Il, Us

Responsible for a variety of projects including billing automation efficiency, development of training material, and presentation review and feedback.

Master Of Business Administration - Mba

Bachelor’S Of Science (B.S.), Chemical Engineering, Biomanufacturing Sciences Minor