Paul Severson Email & Phone Number

San Diego, California, Us

Translational Medicine: Clinical Biomarker and Patient Selection Strategies, Biomarker Discovery and DevelopmentHead of Bioinformatics: Real-World Evidence, Clinical Genomics, Transcriptomics

Translational Medicine: Clinical biomarker strategy, laboratory execution and data analysis. Data Science, Bioinformatics & Biostats. Preclinical PK/PD, efficacy and biomarker discovery studies.

Tucson, Arizona, Us

Postdoctoral Researcher with the Human Genes and the Environment Research Training Program. Working in the cancer epigenomics lab and with the Genomics core facility I've gained the following techniques and skills:• ChIP-Seq using Ion PGM and Proton sequencers• Human Exome Sequencing (using the Ion AmpliseqTM Exome kit and the Proton sequencer from Life Technologies)• Analysis of next-gen sequencing data in Linux (using programs such as Samtools, TMAP, MACS, VCFtools etc.)• Bioinformatic analyses of large datasets using R for statistical computing and graphic display

Tucson, Arizona, Us

Graduate student in the cancer epigenomics laboratory in the Arizona Cancer Center. My graduate student project was to characterize the epigenetic mechanisms of toxicant-induced malignant transformation.Summary of techniques and skills:• MeDIP-on-Chip• Gene expression microarrays, RT-PCR, microRNA expression• Chromatin immunoprecipitation• Bioinformatic analyses of large datasets using R for statistical computing and graphic display• Basic molecular biology and cell culture

As an in vivo and in vitro biologist I conducted animal and cell culture studies to validate the efficacy and mechanisms of action of novel pharmaceuticals. I also conducted pharmacokinetic and toxicology studies.Summary of techniques and responsibilities • Zebrafish microinjections and genetic manipulation• Assay development of small molecule drug screening in Zebrafish embryos• Subcutaneous and orthotopic xenograft studies in athymic and SCID mice• Pharmacokinetic and pharmacodynamic studies in rats and mice• Mouse IV, IP, S.C. and PO dosing• Rodent surgeries (Rat jugular and tail vein catheterizations)• Bioluminescent and fluorescent in vivo small animal imaging• Small animal x-ray• Cell culture• Flow cytometry• Hollow fiber assays• Rodent and fish anesthesia• Immunohistochemistry (both manual and automated)• General Histology