Paul Donegan Email & Phone Number

Portland Oregon

Ensuring product quality through various analytical chemistry techniques. Verification of product composition and absence of microbiological and mold contamination. Working with production to maintain production goals and consistency. Troubleshooting and calibrating analytical and production equipment. Generating and updating QA SOPs

Hillsboro, OR

Contributed to the qualification of Automated Inspection Machines (AIMs) used to inspect outgoing drug product vials. Managed and created drug product vial defect kits used during the AIM qualification process. Managed the execution of defect kit manual characterizations by manufacturing personnel in a GMP environment. Prepared execution packages and.

Vancouver, WA

Performed analytical laboratory testing on product samples in an FDA regulated GMP/GLP environment. Prepared samples for HPLC and GC testing and analyzed results to ensure product met quality and composition standards.

Analysis of subunit stereochemistry and it's affect on novel RNA antisense drug molecules. Utilized solid phase synthesis techniques to create oligonucleotide drug molecules using subunit diastereomers isolated via chiral column HPLC. Looked at the relationship between subunit and oligomer stereochemistry using NMR, mass spectroscopy, and HPLC methods..

Collaborated with a team of engineers from various disciplines to design and implement a low capital cost biodiesel production process. Contributed to the design of a raw material pre-processing process along with an inexpensive methanol recovery system. Involved in continuous process optimization to increase yields and production rate in order to meet.

Worked with software engineer to optimize an automated Western Blot assay machine along with an automated Plasmid Purification machine.+Tested numerous changing versions of each software and logged bugs in a bug tracking program.+Tested the Plasmid and Western machines for software compatibility.-End results from the software/machine compared with previous.

Projects: "Polymerase Chain Reaction (PCR) after methylation sensitive digestion to detect repeat induced point mutation (RIP) mechanism in filamentous fungi,." and "Designing a cytological assay for the pairing phenomenon predicted to occur in RIP"The purposes of these projects were to determine the mechanism by which RIP occurs and to look at how the.