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A versatile and solution-focused Research and Development Leader with 15+ years of in-depth, diverse cross-sector experience spanning the intersection between robust bench science, strong team leadership and mature corporate acumen; enabling better strategies, faster problem-solving and accelerated timelines.Highly motivated with advanced analytical and decision-making skills leading to prompt clear directives at times of crisis or pressure. Uses robust Project and Programme Management knowledge combined with exceptional organisational, multi-tasking and prioritisation skills, honed in a high-pressure, fast-paced environment, to deliver well-structured project plans with clearly identified risks and milestones.Excellent communication skills strategically tailored to the audience, from internal C-Suite/Board level to technical level, to key external parties including investors, scientific collaborators, financial markets and scientific conferences (15 external data presentations), using a variety of media. Skilled at building and maintaining robust professional relationships with all stakeholders based on trust and respect, whilst managing stakeholder expectations, which has led to collaboration agreements, high-impact publications and revenue. People-focused, with excellent interpersonal skills, possessing the ability to work independently or leading diverse groups with a track record of recruiting, training, and building effective teams that maintain an honest, open, data-led ethos.Research and Development Leadership • Building and Leading Effective Teams • Advanced IT skillset (MS Office, Statistics packages, Coding) • Discovery and Preclinical • Multi-disciplinary projects • Complex Problem Solving/Root Cause Analysis • Drug Delivery Strategies • Effective Communication • Deep Science Knowledgebase • Programme and Project Management • Risk Management and Mitigation • Corporate Vision and Strategy • Process and System Development • Commercial and Business Acumen • Crisis ManagementContact email: paul.spencer.hole@gmail.com
Zentraxa
View- Website:
- zentraxa.com
- Employees:
- 13
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ZentraxaCardiff, Gb -
Programme ManagerImophoron Ltd Mar 2023 - PresentBristol, Bristol, Gb -
Programme LeaderReneuron Group Plc Oct 2021 - Mar 2023Bridgend, Gb• Developed and presented a strategy for expansion of exosome programme resulting in company focus shift.• Launched a new platform for drug delivery (ReNeuron CustomEX) in Oct 2022.• Expanded the exosome development group (increased from 4 to 8 members).• Leadership and management of the exosome programme, including communication to Exec committee and Board and contributing to press releases at regular intervals.• Day to day on-site technical leadership and direction of exosome development group. -
Principal InvestigatorReneuron Group Plc Jun 2020 - Oct 2021Bridgend, Gb• Led the team to secure milestones in research projects worth a total of £300K.• Expanded the exosome development group (2 to 4 members) during COVID pandemic and company restructuring.• Led a cross-disciplinary team to design and implement improvements to a manufacturing process, resulting in 160-fold improvement in purity and enabling research project progression.• Managed external collaborations with big pharma and academia.• Trained team members in necessary skills to accelerate development and manufacture of exosomes as therapeutic vehicles. -
Senior Research ScientistReneuron Group Plc Nov 2018 - Jun 2020Bridgend, Gb• Successfully transitioned from academic to industrial research.• Responsible for management and technical aspects external collaboration with clinical stage pharma.• Developed flow cytometric immunoassays enabling progression of collaboration to in-vivo studies and secured further collaborations worth £200K. -
Postdoctoral Research ScientistCardiff University / Prifysgol Caerdydd Apr 2013 - Oct 2018Cardiff, Wales, Gb• In 2018, awarded Leukaemia and Myeloma Research UK Seed Grant - PI, £7K. Funder's first grant recipient.• In 2015, again awarded LLR Programme Grant – Co-applicant, £850K.• In 2013, awarded LLR Programme Grant – Co-applicant, £660K.• Developed a novel technique for studying leukaemia-associated fusion proteins using CRISPR/Cas9.• Developed new models and assays to measure oxidative stress and metabolite production kinetics in leukaemia cells in real time.• Examined the role of aquaporins in redox homeostasis in acute myeloid leukaemia cells.• Investigated the role of catalase export in evasion of cellular stress in AML.• Identified a new oxidative stress-resistant population with stem-cell properties in primary cancer cells, and published findings.• Invited oral presentation at American Society of Haematology, San Francisco, Dec 2014. -
Junior Postdoctoral Research ScientistCardiff University / Prifysgol Caerdydd Apr 2010 - Mar 2013Cardiff, Wales, Gb• Studied the role of NOX-derived hydrogen peroxide in leukaemia cell proliferation.• In 2010, awarded LLR Programme Grant – Co-applicant, £650K• Awarded Kay Kendall Leukaemia Fund Project Grant, £180K -
Pharmacovigilance AssistantShire Jun 2005 - Aug 2005Tokyo, Jp, Jp• Tasked with completing database updates for Dynepo(R) clinical data.• Awarded bonus for completion ahead of schedule. -
Pathology Laboratory MlaNhs Jun 2000 - Feb 2001Gb• Oncological pathology specimen sample preparation for diagnostic analysis and assessment.
Paul Hole Skills
Paul Hole Education Details
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University Of CambridgeNatural Sciences Tripos -
Cardiff University / Prifysgol CaerdyddCancer Biology -
HyperiondevData Science Bootcamp (Funded By Dfe)
Frequently Asked Questions about Paul Hole
What company does Paul Hole work for?
Paul Hole works for Zentraxa
What is Paul Hole's role at the current company?
Paul Hole's current role is Accelerating progress in Life Sciences Research and Drug Development through People, Leadership and Data.
What is Paul Hole's email address?
Paul Hole's email address is ho****@****f.ac.uk
What is Paul Hole's direct phone number?
Paul Hole's direct phone number is +4475288*****
What schools did Paul Hole attend?
Paul Hole attended University Of Cambridge, Cardiff University / Prifysgol Caerdydd, Hyperiondev.
What are some of Paul Hole's interests?
Paul Hole has interest in Politics, Science And Technology, Human Rights, Health.
What skills is Paul Hole known for?
Paul Hole has skills like Research, Molecular Biology, Genetics, Chemistry, Cell Biology, Pharmacology, Science, Microscopy, Cell, Biology, Biochemistry, Lecturing.
Who are Paul Hole's colleagues?
Paul Hole's colleagues are Petra Oyston, Agnieszka Bucholc, Rebecca Davidson, Steve Kenny, Lucy Speight, Kevin Cox, Jack Steventon.
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