Paul Mccoy Email & Phone Number

Pennington, Nj, Us

New York, Us

Abbott Park, Illinois, Us

Technology development and implementation of automation for Phase 1 clinical trials enabling cell line development used in the production of biologic pharmaceuticals. Integration and optimization of bio-layer interferometry, flow cytometery, and microplate imager instruments for determination of protein titer, cell viability/concentration, and cell confluence/growth. Workflow analysis and modeling for process improvement and costs estimation. Perform as liaison and interpreter between scientists, automation vendors, and informatics programmers to ensure production of an effective automated cell line development system.

Valby, Copenhagen, Dk

Improved productivity through automation of compound management, in-vitro screening and analytical chemistry processes. Utilized Lean/Six Sigma principles and Design of Experiments methodology for problem analysis and resolution with compound dilution for assays and instrument optimization. Managed a programmer and multiple high school and summer interns.

Basel, Baselstadt, Ch

Provided technical support of the Lead Discovery Center with operations including compound management, cell and protein production, high throughput screening, and pre-clinical profiling. Primary service support for automated cell culture (TAP SelecT) and automated compound solution archive (TAP SolAr). Primary engineering support for the development of an Assay-Ready Plate system.

Männedorf, Zh, Ch

Developed Cellerity Automated Cell Culture System at Sanofi-Aventis. Performed Acceptance Testing, installation, and methods development as a liaison between Tecan and Sanofi-Aventis. Collaborated with labware vendors on use of disposable cell culture flask and the replacement of re-useable labware with disposable labware. Adapted manual cell culture conditions for optimum cell growth in an automated system. Developed and validated methods for sterilization and prevention of cell line cross-contamination.

Paris, France, Fr

Improved Kinase Selectivity Profiling productivity through assay process optimization and instrument programming. Utilized Design of Experiments methods for assay optimization.

Us

Optimized the assembly process for an In-Vitro Diagnostic Device disposable cuvette utilizing Design of Experiments methodology. Critical variables investigated were UV cure adhesive bonding, assembly environment, and injection molded cuvette. Executed manufacturing process improvement in a cGMP/IVDD environment.

Basel, Baselstadt, Ch

Responsible for instrumentation and equipment, valued over $4.4M, of the Drug Discovery Center. Operated, maintained and provided service support for an automated compound storage and retrieval system (TAP SolAr). Developed maintenance and validation protocols for reagent dispensers and pipetters as well as plate readers and imagers. Supervised a laboratory technician in developing and implementing instrument validation protocols. Integrated equipment and instrumentation into drug discovery screening systems.

Developed homogeneous, cell, and particle based drug discovery assays. Designed, developed, and implemented apparatus and equipment for screening of small molecule pharmaceutical compounds. Developed and validated dry film compound management methods for low volume screening. Designed electro-mechanical, fluidic, and mechanical components utilizing tools such as 3D engineering graphics and high-speed video. Developed calibration and validation protocols for testing ultra-high throughput screening equipment and disposable lab ware.

Designed, certified, and tested compressed air and gas drying systems. Managed daily operation of product testing laboratory. Wrote and developed design and test procedures and standards for ISO9001, UL/CSA and CAGI. Performed safety certification of dryers to UL and CSA standards and was responsible for quarterly on-site compliance inspections and report maintenance. Wrote PLC and Windows-based PC process control software to control air and gas dryers and allow their integration into Building Management Systems (DataLink PC).

Designed refrigeration systems for food service and institutional equipment. Tested products for compliance to NSF and UL standards. Instructed/scheduled work for development laboratory technician.

Developed built-to-order environmental chambers, from concept through production, controlling temperature, relative humidity, and lighting. Wrote software for distributed control systems used for in-house testing and product development. Designed sheet metal parts and production tooling for commercial point-of-sale refrigerators. Designed control systems for blood bank refrigerators, diurnal and pharmaceutical product stability incubators, research animal and plant growth chambers.