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Preclinical scientist with a 15-year track record of driving innovation in translational research at world leading institutions. Expertise in managing in vivo biomedical projects across a number of areas (Alzheimer's disease, oncology, neuromuscular medicine) with an emphasis on the application of anatomical and functional imaging modalities for preclinical evaluation and biomarker discovery. Also, experience in applied nanotechnology, encompassing polymer and graphene based drug delivery systems. Focused on achieving excellence through a multidisciplinary approach that enables the fusion of diverse ideas to achieve greater goals. Strengths in communicating complex data to a variety of audiences demonstrated by articles in peer reviewed scientific journals, conference presentations, teaching lectures and public outreach. Always seeking new challenges, learning from others and committed to excellence.
Medicines Discovery Catapult
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Lead ScientistMedicines Discovery Catapult May 2023 - PresentAlderley Edge, England, United Kingdom
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Senior ScientistMedicines Discovery Catapult Sep 2020 - May 2023Alderley Edge, England, United Kingdom
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Preclinical Research ScientistThe University Of Manchester Apr 2018 - Apr 2020Manchester, United KingdomResearch area: Nanotechnology, Neuro-oncology, Drug deliveryThe principle objective was to exploit the unique properties of graphene-based materials to develop innovative solutions for unmet clinical need (EPSRC funded). My specific role was to establish and optimise preclinical cancer models for evaluating the potential of graphene-based materials as multifunctional drug delivery platforms. Furthermore, to apply existing imaging modalities (MRI, optical) to determine in vivo functionality and therapeutic efficacy of novel graphene-based nanocarriers. -
Senior Research AssociateThe University Of Sheffield Apr 2014 - Apr 2018Sheffield, United KingdomResearch area: Alzheimer's disease, cerebral blood flow, neuroimaging.The principle objective was to explore the pathogenic contribution of cerebrovascular dysfunction in Alzheimer's disease (ARUK funded). My role was to provide scientific expertise at all stages of the research programme including the design, execution, data interpretation and communication. This involved implementing novel in vivo imaging research methodologies, performance management to meet project milestones, direct supervision of researchers, develop the team's strategic interests through internal/external collaborations and disseminate the research findings through high-quality publications and conference presentations. -
Project ManagerUniversity Of Sheffield Jul 2009 - Oct 2014Sheffield, United KingdomResearch area: Nanotechnology, Pharmaceutics, Neurodegenerative disease.The principle objective was to demonstrate proof-of-principle for a polymer-based nanoparticle drug delivery system targeting the CNS (EPSRC funded). My role was to manage the development pipeline of new polymer formulations from optimising in vitro functional assays, through to applying in vivo optical methods to evaluate nanoparticle pharmacokinetics/biodistribution and developing high-resolution microscopy to determine penetrance into the CNS. Efficient and effective communication across cross-functional groups to support the flow of information was paramount in order to achieve project ambitions.
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Postdoctoral Research AssociateImperial College London Jun 2004 - Jul 2009London, United KingdomResearch area: Neuromuscular medicine The overarching theme was to develop viral and non-viral genetic therapies to treat motor neurone disease and Duchenne muscular dystrophy (Dept. of Health UK funded). My primary responsibilities were to manage, collate, interpret and communicate high quality translational data to accelerate the development of novel therapeutic strategies for neuromuscular diseases. My key outputs were focused on the preclinical functional evaluation of gene-modifying approaches, achieved either though the generation of transgenic overexpressing mice, viral gene therapy, or exon-skipping based strategies. A significant development has been the first FDA-approved Duchenne muscular dystrophy treatment (EXONDYS 51), an exon skipping therapy that in principle is the same strategy that showed much promise in preclinical evaluations that I conducted (see links). -
Postdoctoral FellowUniversity Of Alberta May 2003 - Jun 2004Edmonton, Canada AreaResearch area: Neurodegenerative disease The principle objective was to advance our understanding of the pathophysiology of motor neurone disease (CIHR funded). My role was to implement a rejsearch program to characterise disease progression in a mouse model of MND and investigate whether promoting peripheral nerve regeneration can ameliorate disease severity.
Paul Sharp Skills
Paul Sharp Education Details
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Frequently Asked Questions about Paul Sharp
What company does Paul Sharp work for?
Paul Sharp works for Medicines Discovery Catapult
What is Paul Sharp's role at the current company?
Paul Sharp's current role is Lead Scientist Translational Imaging.
What is Paul Sharp's email address?
Paul Sharp's email address is p.****@****d.ac.uk
What schools did Paul Sharp attend?
Paul Sharp attended University College London, U. Of London, Ucl, Goldsmiths College, U. Of London.
What skills is Paul Sharp known for?
Paul Sharp has skills like Microscopy, In Vivo Electrophysiology, In Vivo Multiphoton Microscopy, Cerebral Blood Flow Imaging, Muscle Physiology, Pharmacokinetics, Molecular Biology, Nanomedicine, Drug Delivery, Cell Culture, Confocal Microscopy, Cell Biology.
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