Linux (Ubuntu) systems administrator for a longitudinal research projectEnsure database (MySQL) integrity and data consistency via close collaboration with usersDevelopment of customized data capture form and scoring scripts for web based application (Loris)Language: PHP, MySQL

Drug discovery projects core team memberProvided guidance to discovery teams to improve DMPK properties of newly designed compoundsProposed and implemented strategies for compounds evaluationIdentified DMPK liabilities and implemented mitigation strategiesSupported efficacy and toxicological studies by providing PK profile predictions and proposed dose regimensBridged gaps between in vivo biology, in vitro pharmacology, DMPK and chemistryLead the integration of competitive knowledge into a drug discovery project

DMPK core team member on novel drug discovey projectsActed as a DMPK consultant for drug discovery projects running at other AZ sitesImplemented the AZ Reactive Metabolite Strategy in MontrealCo-authored the AZ Reactive Metabolite StrategyChaired the Global Biotransformation User GroupDeveloped and implemented a local biotransformation strategy in line with local business prioritiesConceived a new web-application to simplify request submissions and follow-upIntegrated an early PKPD model into compound progressionImplemented the Compound Management System within the Medicinal Chemistry DepartmentActed as an internal consultant on reactive metabolites for drug discovery projectsEstablish and lead a small group of Biotransformation scientists at the Montreal siteCoached scientists during their integration period

Acted as deputy Core Team Member on novel drug discovery projectsReduced turn-around time of metabolic stability assay by half by introducing the use of automated liquid handlersImplemented ChemStore db to automate LC/MS data archiving/storageConceived a new informatics tool to automate injection sequences and data analysis on mass spectrometer (Agilent MSD)Automated metabolic stability assays on a Tecan systemManaged the development of ChemStore/ChemAnalyzer applications to document metabolic profile of new compounds

Built a new ADME lab at the Montreal facilityDeveloped and implemented in vitro metabolic stability screening methods

Developed an in vitro hepatocyte model for metabolism studies (1995-1996)Identified non-CYP mediated metabolism of a lead molecule (1995)