Selected projects include:PHARMACOMETRICS CLOUD INTEGRATION• Implemented platforms (Metworx) and tools for performing PK/PD modeling and simulation in Cloud using AWS, including seamless integration with existing execution environment on in-house compute grid• Built proof-of-concept (POC) parallel cluster env. for R/R-Studio/RS-Connect with AWS team and IT teams to execute R and R-Shiny programs in AWS cloud with strict separation of regulatory activities from other work • Developed custom tools and scripts to enable new functionality and eliminate error-prone manual operationsVIRTUAL SYSTEMS PHARMACOLOGY PLATFORM (BMS)• Saved millions of $$ in increased productivity and potential avoidance of costly clinical trials by designing a highly flexible platform for clinicians to run prepared simulations on demand, vs. having to request that such calculations be prepared by modelers• Enabled novel modeling approaches (using quantitative physiological models) by reducing their complexity to a user-friendly interface and integrating with a cloud-based grid for computational load.MODEL EXPLORER (Merck)• Enabled faster, better decision making by enhancing collaboration between modelers & clinical teams, with an application to interactively explore effects of changing model parameters or clinical trial conditions• Teamed with functional areas (M&S, Clinical, IT) to harmonize business processes across globally distributed groupseMASTER (M&S Tracking, Evaluation and Reporting) (BMS)• In only 2 weeks, designed an innovative prototype to manage, track, analyze, visualize and report on scientific modeling results, then turned into a project to build the full-scale application• Eliminated time-consuming manual processes, provided significant competitive advantage, saving 2-3 hours/day.• Designed/built multi-server networked 3-tier application with web front-end & compute farm back-end, integrated into high perf. computing grid, managed entire validation process

• Improved efficiency and productivity by at least 25% by implementing a customized application for managing modeling calculations and their results• Enabled capture of institutional knowledge, sharing of information, and re-use of previously built models through design and implementation of a customized third-party application to serve as knowledge repository for drug/disease models• Managed relationships between functional groups, IT, and vendor, and collaborated with vendor to design functionality, manage priorities, resources, scope and changes

• Assessed lack of capabilities, integrated tools and techniques to achieve competitive advantage, attract top talent, improve efficiency and mitigate regulatory risks.• Developed a road map of initiatives necessary to implement business and IT strategy, defined technology solutions architecture within global enterprise framework, and harmonized business processes across functional and regional areas

• Converted lab operations for metabolism research from paper to custom electronic lab notebook, that serves as central knowledge repository, making data easily accessible, searchable and shareable, with derived results directly associated with data captured from instruments• Saved 2-3 hours / day / user by enabling scientists to generate and capture data much more efficiently and redesigning associated business processes• Collaborated with vendor to design functionality, including storage & searching of non-specific structures, and instrument data capture and automatic uploads

• Built data center to serve as the new disaster fail-over site and increased capacity. Deployed 200+ nodes in a distributed computing architecture. Prepared, implemented and executed disaster recovery procedures. Developed corporate change management process, designed capacity planning strategy, new backup architecture, and security standards; created standard operating procedures (SOPs) • Hired and managed the system administration team (staff of 5). Led projects to provide application services to new clients.

• Made strategic technology and architecture recommendations to meet future scientific computing needs. Provided management and validation expertise. Advised on strategy decisions as active member of Discovery Informatics computing infrastructure committee• Integrated newly acquired West Coast research laboratories by coordinating required infrastructure and aligning business processes

• Engineered solutions for all technologies (servers, network, desktops) for the entire company in FDA regulated environment. Managed a list of 170+ projects. Designed solutions to automate and integrate business processes for clinical trials, document management, regulatory submissions, and data warehouse efforts• Ensured availability of systems and services for business-critical processing. Directed and implemented strategy and best practices for service delivery following ITIL principles. Designed standard configurations and operating procedures. Implemented suite of tools for enterprise management and proactive monitoring • Hired and supervised teams of up to 25. Conducted employee performance reviews

• Provided systems management support for R&D computing (molecular design, spectroscopy, and clinical statistics) at Abbott Laboratories• Responsible for numerous software packages for molecular modeling, numerical computations, and graphical manipulations, as well as their integration into the infrastructure; managed network of over 90 UNIX workstations and servers

• Developed new methods and algorithms for analysis of NMR spectroscopic data• Wrote programs for Linear Prediction, Maximum Entropy, and Bayesian Analysis applied to modeling of 1-D and 2-D NMR spectra• Managed software build and release cycles