• Perform non-clinical drug safety testing and drug discovery studies, responding promptly to customer questions, providing interpretation of results, and suggesting follow-up assays when appropriate• Coordinate with client manager, scientific support staff, project coordinator, and archivist to determine appropriate study scope, conclude the study within the expected time frame, and ensure that study documentation is complete• Coordinate with study monitors to report… Show more • Perform non-clinical drug safety testing and drug discovery studies, responding promptly to customer questions, providing interpretation of results, and suggesting follow-up assays when appropriate• Coordinate with client manager, scientific support staff, project coordinator, and archivist to determine appropriate study scope, conclude the study within the expected time frame, and ensure that study documentation is complete• Coordinate with study monitors to report results in the desired format (e.g., using client database portals when requested)• Write SOPs and internal resource documents• Create complex Excel templates which help to make scientific procedures and data analysis more consistent and efficient• Coordinate service on equipment and maintain adequate supply of materials• Train other scientists in scientific and support procedures Show less

• Developed and validated new assays based on customer requests and expected customer demand• Troubleshot problems with assays and designed experiments to identify sources of variability and potential experimental artifacts• Coordinated with cell culture group to test clones of newly developed cell lines while also running studies on existing assays in the same time frame• Developed procedures for using automated liquid handling systems for use with 384-well and… Show more • Developed and validated new assays based on customer requests and expected customer demand• Troubleshot problems with assays and designed experiments to identify sources of variability and potential experimental artifacts• Coordinated with cell culture group to test clones of newly developed cell lines while also running studies on existing assays in the same time frame• Developed procedures for using automated liquid handling systems for use with 384-well and 96-well plate-based assays• Contributed to multiple projects in which customer assays were adapted for high throughput screening, coordinating with the CRL site in the UK to provide compounds for the HTS study and to process results, including one project for which I was study director in which 200,000 compounds were screened Show less

• Developed and validated new assays based on customer requests and expected customer demand• Troubleshot problems with assays and designed experiments to identify sources of variability and potential experimental artifacts• Coordinated with cell culture group to test clones of newly developed cell lines while also running studies on existing assays in the same time frame• Developed procedures for using automated liquid handling systems for use with 384-well and… Show more • Developed and validated new assays based on customer requests and expected customer demand• Troubleshot problems with assays and designed experiments to identify sources of variability and potential experimental artifacts• Coordinated with cell culture group to test clones of newly developed cell lines while also running studies on existing assays in the same time frame• Developed procedures for using automated liquid handling systems for use with 384-well and 96-well plate-based assays• Contributed to multiple projects in which customer assays were adapted for high throughput screening, coordinating with the CRL site in the UK to provide compounds for the HTS study and to process results, including one project for which I was study director in which 200,000 compounds were screened Show less

• Developed heterologous cell lines stably expressing ion channel proteins for use in non-clinical drug safety testing and drug discovery studies• Developed a novel assay to identify compounds which have a safety risk not detectable by existing assays; this assay (hERG-Lite assay) resulted in a publication and a patent• Designed an adaptor which allowed our existing automated plate washers to be used to wash seal chips used on an automated patch-clamp instrument and… Show more • Developed heterologous cell lines stably expressing ion channel proteins for use in non-clinical drug safety testing and drug discovery studies• Developed a novel assay to identify compounds which have a safety risk not detectable by existing assays; this assay (hERG-Lite assay) resulted in a publication and a patent• Designed an adaptor which allowed our existing automated plate washers to be used to wash seal chips used on an automated patch-clamp instrument and worked with a machine shop to create these, semi-automating the washing procedure and improving throughput• Created moderately complex Excel templates to aid scientific support procedures Show less

Performed research investigating mechanisms of RNA polymerase II transcription. Research led to a revision of the model for transcriptional arrest.