My Laboratory is studying the mechanisms that promote DNA Repair and Genome Editing.We employ cutting-edge genome editing technologies (CRISPR-transposons, base editing, and prime editing), high-throughput genetic screens in cell lines and in vivo, biochemical assays, cell biology experiments, and mouse models to interrogate and manipulate the cellular mechanisms that protect our genome. Studying and controlling the cellular DNA damage response will provide new insights into the… Show more My Laboratory is studying the mechanisms that promote DNA Repair and Genome Editing.We employ cutting-edge genome editing technologies (CRISPR-transposons, base editing, and prime editing), high-throughput genetic screens in cell lines and in vivo, biochemical assays, cell biology experiments, and mouse models to interrogate and manipulate the cellular mechanisms that protect our genome. Studying and controlling the cellular DNA damage response will provide new insights into the mechanisms that promote genome stability to enhance cancer treatments and improve the accuracy, efficiency, and safety of modern precision genome editing technologies for the treatment of human genetic diseases. Show less

The DNA damage response network in cancer and genetic disorders, and development of novel genome editing technologies. (Alberto Ciccia's lab)Inventions:- iSTOP (https://www.cell.com/molecular-cell/pdfExtended/S1097-2765(17)30605-6)- DTECT (https://www.cell.com/action/showPdf?pii=S2211-1247%2820%2930236-9)

Functions and regulatory roles of acetylation to maintain the integrity of the genome. (Jacques Coté's lab)

Mechanisms of DNA replication stress in cancer. (Thanos Halazonetis' lab)

Identification of RNA and DNA binding proteins by the surface plasmonic resonance andmass spectrometry technology. (Anne-Catherine Prats' lab)

Characterization of XRCC-4 phosphorylations in response to DNA damage. (Patrick Calsou's lab)