Pierre Romé, Phd Email & Phone Number

Montpellier, Occitanie, Fr

Montpellier, Occitanie, France

Montpellier, Occitanie, France

Montpellier, Occitanie, France

• Technology transfer of an anti-cancer drug screening assay to a biotechnology company• International collaboration• Grant proposal writing and proofreading• Biochemical characterisation of enzyme/substrate relationships• Mammalian tissue culture and microscopy• Fundamental project lead.

Edinburgh, United Kingdom

1) Proof of concept of an in-vitro assay to identify novel anti-cancer molecules.• Personal grant awarded for the project: Wellcome Institutional Partnership Award (Wellcome iTPA)• Design and development of the proof of concept of the assay• Invention disclosure with the TTO of the University of Edinburgh• Establishment of a technology transfert to a French biotech------------------------------------------------------------------------------------2) Development of a high-throughput enzymatic assay to identify novel inhibitors of an enzyme involved in fibrosis (supervised by Pr. Scott Webster)• In collaboration with Astra Zeneca• Project lead for the development and the upscaling of the screening pipeline• Budget estimation of the total screening cost + reagent supply organisation• Screening of 1 million compounds against the targeted enzyme (at AZ)• Pharmacology analysis of positive hits (IC50, Km, in cellulo validation)• Protein purification from mammalian cells via AKTA• Supervision of two Master students------------------------------------------------------------------------------------3) Design and development of microscopy-based drug discovery screening pipeline to find anti-cancer drug against prostate cancer (supervised by Pr. Neil Carragher)• Project lead for the design and development of the screen• Mammalian tissue culture, viral transduction• Validation of the setup to pharma standards (Coefficient of variation, Z-factor, reproducibility)• Screen of a small molecules library via automated Incucyte microscopy• Pharmacology analysis of positive hits: IC50, in vivo efficacy (in progress)• Invention disclosure (in progress)• Publication of the proof of concept (in progress)

Edinburgh, Royaume-Uni

• Design and development of a novel in vitro microtubule nucleation assay in Drosophila• Fundamental project lead: Identification of a novel microtubule nucleation pathway in Drosophila oocytes• Publications in international scientific journals • Supervision of two PhD students• 9 oral presentations (including one best presentation award) and 8 scientific posters to international conferences

Rennes, Brittany, France

• Fundamental project lead: Identification of new partners of the oncogenic Aurora A Kinase during Mitosis

• Identification of new partners of Aurora A Kinase during Mitosis in Drosophila melanogaster.

• Study of the subcellular localisation of Sanpodo, a co-activator of the Notch pathway in Drosophila melanogaster

• Topic of research: Study of the NeuroD promoter of Xenopus laevis

Post-Doctorat, Biology

Doctor Of Philosophy - Phd, Biology, General

Master Of Science - Ms, Cell/Cellular And Molecular Biology

Bachelor Of Science - Bs, Cell/Cellular And Molecular Biology

Phd, Biology/Biological Sciences, General