Pilgrim Jackson Email and Phone Number
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Biochemistry LeaderI am a motivated drug hunter, keen on delivering dynamic therapies using the most efficient available modalities and methodologies. I have extensive experience building and leading multidisciplinary teams to tackle challenging drug discovery problems in the areas of inflammation and oncology. In my role at Celgene, a company best known for creative use of under-appreciated assets and data, I recognized the gap between informatics and bench science as the biggest challenge facing drug discovery. The ease with which current 'omics technologies can gather millions of data points was creating large datasets that were being wasted. To address this inefficiency I sought and was granted permission to build a cross-functional group that utilized both experiment and bioinformatic analysis. This “systems proteomics” group used rapid iteration cycles to turn large data sets into actionable knowledge. In this capacity we were able to identify numerous novel protein degrader targets. Additionally, this approach uncovered biological pathways and mechanisms of action that revealed new biomarkers. Together with the protein sciences group I managed, we delivered 6 therapeutics to clinic resulting in 4 patents over the course of 8 years. The process of building and leading these groups has given me a broad understanding of early research through translational development. Moving forward I hope to build on these pioneering ideas to continue addressing the fundamental gaps in biopharmaceutical research. I have extensive experience in key aspects of protein science including; proteomics, molecular biology, protein expression, protein purification, crystallography, protein-NMR, display technologies, SPR, LC-MS, assay development and small molecule screening
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Ceo/FounderYatiri Bio Inc. Jun 2020 - PresentYatiri Bio is committed to revolutionizing therapeutic discovery. We develop cutting edge proteomics and bioinformatics tools to create preclinical models capable of predicting patient outcomes. Yatiri Bio is dedicated to integrating our proteomic knowledge-base, tailored models, and clinical proteomics for patient stratification and molecular subtyping, to drive improved patient outcome. Tools developed for:• Pathway biomarker identification• Patient stratification• Partnered drug discovery• Drug repurposing -
Sr. Principle Scientist/Associate DirectorCelgene Oct 2016 - Jun 2020Summit, New Jersey, UsHead of the Systems Proteomics GroupAggressively recruited top talent, built, and led a “systems proteomics” group integrating proteomics, bioinformatics, and cellular biology. Orchestrated integration of the group with all aspects of early research and development, supporting teams froovery biology through preclinical toxicology. The self-contained nature and strong informatics allowed the group to harness the vast amount of information available, turning it rapidly into actionable knowledge.• Led the systems proteomics group exploring protein homeostasis and ligase biology. • Developed assays to determine targets and downstream pathways of small molecule ligase modulators.• Identified small molecules and PROTACS that direct ligases to degrade therapeutically relevant oncology targets.• Coordinated an outsourced proteomics/informatics project on an unprecedented scale to support drug discovery efforts• Optimized methodologies to run global proteomics on in vivo samples.• Proteomics support for project teams including compound selectivity and MoA.• Significantly shortened turnaround from informatics through hypothesis testing, from months to weeks. -
Sr. Scientist/Principal ScientistCelgene Oct 2011 - Oct 2016Summit, New Jersey, UsProtein Sciences Group LeaderBuilt, managed and oversaw the protein sciences and biophysics group of 8 people +CRO support. The group supported the R&ED needs for protein production, proteomics and SPR assays for the biotherapeutics, oncology and inflammation departments across multiple sites.• Created a team and system that could support the introduction of biotherapeutics, a new modality for the company• Core project team member for drug discovery projects across multiple modalities.• Antibody and antigen production to support all biotherapeutic needs from project conception through non-GLP tox studies. • Protein production for crystallography, enzymology and biophysical analysis. • Biophysical analysis of protein-protein, protein-ligand and antibody interactions using SPR, BLI, FTM, SEC-HPLC and LC/MS. . -
Scientist I/Scientist IiCelgene Jan 2007 - Oct 2011Summit, New Jersey, Us• Managed the protein sciences group with oversight of protein production for crystallography and enzymology • Protein crystallography: data collection and structure solution.• Biochemistry representative for Epigenetic targets.• High throughput analysis of aggregation prone proteins. -
Postdoctoral ResearcherUniversity Of California, Irvine Aug 2005 - Dec 2006Irvine, Ca, UsWorked with professor Greg Weiss on novel applications of phage display to study aggregation prone proteins and peptides.
Pilgrim Jackson Skills
Pilgrim Jackson Education Details
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Yale UniversityMolecular Biochemistry And Biophysics -
University Of California, Santa CruzBiophysical Chemistry
Frequently Asked Questions about Pilgrim Jackson
What company does Pilgrim Jackson work for?
Pilgrim Jackson works for Yatiri Bio Inc.
What is Pilgrim Jackson's role at the current company?
Pilgrim Jackson's current role is Founder/CEO, Yatiri Bio | Informatics and Proteomics.
What is Pilgrim Jackson's email address?
Pilgrim Jackson's email address is pj****@****ene.com
What is Pilgrim Jackson's direct phone number?
Pilgrim Jackson's direct phone number is +190867*****
What schools did Pilgrim Jackson attend?
Pilgrim Jackson attended Yale University, University Of California, Santa Cruz.
What skills is Pilgrim Jackson known for?
Pilgrim Jackson has skills like Protein Purification, Protein Chemistry, Molecular Biology, Proteomics, Peptides, Elisa, Nmr, Lc Ms, Hplc, Peptide Synthesis, X Ray Crystallography, Protein Production.
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