Prasad Krishnan Email & Phone Number

Greater Noida

I train caregivers to prepare for abroad assignments, as part of Skill India project. The training includes personality development, effective communication in English and interview preparation.

Kottayam, Kerala, India

Kottayam, Kerala, India

Kottayam, Kerala, India

I train Nursing Graduates in Speaking Module of OET examination through role plays pertaining to various real-life medical/healthcare situations. In addition, I teach English Grammar to Nursing graduates focusing on OET examination modules.

I train health care professionals, who aspire to migrate to Middle East and Commonwealth Nations, in medical communication. Training modules include role plays and case studies.

I collaborate with physicians practicing Ayurveda, the Indian system of medicine, to collect and collate clinical information. I prepare scientific articles, based on the analyzed data, to publish in leading ayurvedic journals.

University Park

My work focussed on understanding the molecular mechanism behind the antiviral activity of 2’ modified nucleoside analogs against the viral RNA-dependent RNA polymerase (RdRp) enzyme found in the viruses causing acute and chronic diseases like common cold, encephalitis, myocarditis, hepatitis and paralytic poliomyelitis.

State College, Pennsylvania Area

I investigated the role of Pparβ/δ in various cancers like skin, prostate, liver and lung. I used in vitro and in vivo models to elucidate the anti proliferative and anti inflammatory role of this nuclear receptor. The preliminary results showed that activating this nuclear receptor provides protective effects against in cancer.In a collaboration project with 3M Company, I investigated the mechanism of liver toxicity of PFOS (perfluorooctane sulfonate). I used metabolomic analysis to identify the changes in the metabolite profile with PFOS treatment.In a collaboration project, with Dupont, I worked on the developmental toxicity of PFOA (perfluorooctanoic acid). The results showed that PFOA did not produce developmental toxicity in mice with humanized Ppar-α receptor.

Storrs, Connecticut

My area of study was the small intestinal ulceration after administration of NSAIDs like diclofenac andnimesulide. The in vitro studies were done in rat small intestinal cells to understand the effect of these compounds on ER (endoplasmic reticulum) stress and to elucidate the role of ER stress in small intestinal ulceration. The in vivo studies were performed in mouse model of enteropathy.

Shreveport, Louisiana Area

My project was on the chemopreventive effects of auraptene (a natural compound found in citrus fruits) against breast cancer. I demonstrated the chemopreventive effects of auraptene in the MNU-rat mammary cancer model and also in human breast cancer cell lines. Through HPLC analysis I estimated the concentration of auraptene in the rat mammary tissues after dietary administration. The cell cycle analysis followed by qRT-PCR array indicated that auraptene inhibits DNA synthesis and modulates cell cycle machinery.In a second project, I was part of the Breast Cancer Focus Group at LSUHSC-Shreveport and I analyzed human breast cancer tissues for cancer biomarkers. I compared the results from human and rat mammary tissues to identify the biomarkers modulated by my test compound, auraptene.

Chicago

I analyzed the rate and extent of absorption of nanoparticles of various sizes under different experimental conditions using flow cytometry. This project gave me the opportunity to work under FDA guidelines.