Prashanth Ananth Email & Phone Number

San Francisco, Ca, Us

Kansas City, Missouri, United States

• Designing and leading preclinical research with the following focuses: A) Exploring the efficacy of phospholipid nanoparticle colloid-small molecules for treating severe sepsis by modulating inflammatory factors and signaling pathways. B) Investigating the reversal of clinical death following hemorrhagic shock through intra-arterial infusion of phospholipid nanoparticle colloids. • Engaged in clinical research through collaboration with Vivacelle Bio Inc., where along with a team of clinicians I evaluated the effectiveness of novel phospholipid nanoparticles for treating relative hypovolemia and hypotension in septic shock patients. We are progressing towards phase III of the clinical trial. • Expertise in developing hypothesis-driven proposals, designing studies, executing experiments, managing projects, establishing laboratories, and engaging in scientific writing, including SBIR and STTR grant writing. • Mentoring post-doctoral fellows, residents, and medical students in the laboratory.

Pullman, Washington, United States

• Developed a serine protease inhibitor as an innovative over-the-counter contraceptive method. Our research garnered attention and was featured in various online news outlets. Currently, serine protease inhibitors are undergoing testing for birth control in female rhesus macaques in vivo. • Developed, screened, and optimized enzyme assays for Prostate-specific antigen inhibitors as part of NIH X01 project. • Defined the molecular mechanisms integral to estrogen signaling in the oviduct during fertilization and pre-implantation embryonic development. Utilizing cell-type specific estrogen receptor alpha (ERα) knockout mice, investigated how estrogen contributes to the establishment of early pregnancy. • Established productive scientific collaborations to fulfill project requirements and enhance research outcomes. • Trained graduate and undergraduate students and actively supervised their research projects.

Detroit, Michigan, United States

• Pioneered novel research into the identification of estrogen receptor alpha (ERα) splice isoforms and their regulation during human pregnancy utilizing clinical samples. This was the first report that established ERα splice variants as the primary regulators of uterine contractile behavior throughout pregnancy. • Investigated the role of Steroidogenic Factor 1 (SF-1) in Sertoli cell function utilizing knockout mouse model. • Evaluated existing and established new laboratory protocols. • Trained graduate/undergraduate students and helped supervise their research projects.

Pittsburgh, Pennsylvania, United States

• Explored the critical function of hypothalamic phosphodiesterase-3B (PDE3B) in mediating the regulatory effects of leptin and insulin, employing both diet-induced obesity and knockout mouse models. • Investigated the impact of PDE3B over-expression and knockdown on Neuropeptide Y gene expression in a hypothalamic neuronal cell line.

Hyderabad, Telangana, India

• Examined the role of Retinyl Palmitate in the regulation of obesity using a mutant rat (WNIN/Ob) model. • Identified the key genes involved in thermogenesis, adipogenesis, apoptosis and glucocorticoid metabolism pathways, and their regulation by vitamin A in mediating anti-obesity effects.

Visakhapatnam, Andhra Pradesh, India

• Study of host specificity in the entomopathogenic fungus Beauveria bassiana. Study was funded by Andhra Pradesh-Netherlands Biotechnology Program.

Doctor Of Philosophy - Phd, Biochemistry

Master Of Science - Ms, Biotechnology, A

Bachelor Of Science - Bs, Biotechnology, A