Preeti Gupta Lal Ph.D Email and Phone Number
Experienced leader in data Science, translational medicine, clinical biomarker and CDx implementation in all phases of clinical trials development, regulatory interactions with both the drug and device divisions of FDA, and companion diagnostics (Dx) programs. Co-inventor on >150 patents. Led a very exciting and diverse teams involved in the discovery of novel therapeutics in Immuno Oncology, Gastro-Intestinal diseases and a team of engineers/informatics using cutting edge Machine learning methods to develop predictors of response to drugs by analyzing diverse data from both host and microbiome. Worked at several leading healthcare companies:• Alladapt Immunotherapeutic: led translational medicine and data science projects in multi food allergy• Roche Diagnostics: worked on liquid biopsy and digital health• Gilead Sciences: led Gilead first companion Dx program; focused on clinical biomarkers and companion Dx across a range of therapeutic indications including Oncology and immunology• Genentech: led biomarker development work in asthma and autoimmune diseases including leading a companion Dx program in an immunology indication • CareDx: Used Big data and machine learning to develop the diagnostic algorithm “AlloMap” containing multiple gene expression values; approved under IVDMIA guidance by FDA as an aid in the management of heart transplant subjects and reduce routine heart biopsies. • Incyte Genomics: managed a bioinformatics group involved with data mining and usage of novel methods for the discovery of drug targets and biomarkers including secreted proteins and the analysis of laboratory data from cell-based assays. Core technical expert on numerous pharma collaborations.
Vgenomics - Your Dna Decoder
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Cso And CofounderVgenomics - Your Dna Decoder Apr 2022 - PresentNoida, Uttar Pradesh, InWorking on diagnosis and drugs for rare diseases by harnessing the power of NGS, big data, and machine learning
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Chief Scientific OfficerSecond Genome Inc. Jan 2021 - Jan 2022South San Francisco, Ca, Us -
Scientific AdvisorAlladapt Immunotherapeutics Jan 2021 - Jan 2022
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Vice President Of Development Sciences And Translational MedicineAlladapt Immunotherapeutics, Inc. Oct 2018 - Jan 2021Menlo Park, California, Us -
OncologyRoche Sequencing Feb 2017 - Oct 2018Worked on 1)Understanding and analyzing Real-world data2)Developing and executing a strategic plan for cancer genomics and bioinformatics3)Understanding the need for the products and R&D in cancer analysis and assays and 4)Leading and providing direction for cancer research and cancer bioinformaticsdevelopment. 5) Involved in big data and data science of NGS and interpretation for therapy
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Technical Advisor3S Ventures Inc Sep 2016 - Feb 2017
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Director, Clinical Biomarker And Companion DxGilead Sciences Jun 2012 - May 2016Foster City, Ca, Us• Led post marketing commitment submission to determine mechanism of resistance in CLL for IDELA using exome sequencing by NGS• Instrumental in concept and design of translational study in collaboration with clinical science to find subpopulations which would benefit from new molecular entity.• Established the bioinformatics group; hired and managed a team of nine Ph.D. s charged with serving the needs of the research biology and biomarker group.• Designed research plans across all technology platforms (genomics, transcriptome, metabolome and proteome, an and microRNA) to support translation efforts from pre-clinical species to humans.• Experience in PK/PD modeling and understanding of safety findings and biomarkers.• Led the first Gilead potential companion diagnostic assay development in collaboration with a diagnostic partner. Managed the effort from inception including due diligence involved with the selection of the diagnostic partner.• Collaborated with CRO, clinical operations and sample management teams to ensure optimal biomarker testing and data collection in clinical trials. • Led biomarker strategy for clinical studies in Inflammation, Fibrosis, Respiratory and Cardiovascular diseases in phase I, II and III studies. -
Personalized Health Care LeaderGenentech Mar 2008 - Jun 2012South San Francisco, California, Us• Biomarker lead for the anti-IL13 (Lebrikizumab) program with periostin as companion diagnostic.• Collaborated with a network of external KOLs and clinical research partners on leading the translation strategies that supported Periostin as novel biomarker.• Led Asthma Diagnostic team to implement companion diagnostics in phase III program of Lebrikizumab including getting central labs ready for phase III program in accordance with FDA regulation.• Participated and supported regulatory meetings with PGWP, Pre-IDE, End of Phase II meeting with FDA and EMA as core member representing biomarker (companion Dx) of Global Development team.• Developed and implemented clinical biomarker strategies for late-stage respiratory immunology clinical programs.• Provided expert advice to clinical teams for the optimal design and conduct of clinical trials with diagnostic as well as optimal PD markers.• Provided ongoing monitoring of biomarker and diagnostic activities, ensuring effective wet lab support, coordination of data collection and interpretation and preparation of the results for informed decision-making.• Led the Rheumatoid Arthritis Diagnostic team to find predictive biomarkers. Supported five NMEs from phase I to marketed products resulting in two first author publications• Set the processes and paths for the utilization of critical clinical trial residual PK samples for biomarker validation.• Translated clinical and commercial needs into Personalized Health Care biomarker discovery strategies/priorities. -
Assoc DirectorXdx Is Now Caredx, Inc. 2003 - 2008• Performed a dual role in the company as strategic manager of the intellectual property as well as for clinical studies and data. Reported directly to the CSO.• Developed the statistical algorithm AlloMap containing multiple genes approved under IVDMIA guidance by FDA as an aid in diagnostic for heart transplant (AlloMap).• Participated in and contributed to multi-disciplinary groups providing bioinformatics solution for development of predictive algorithm, IP search strategies, SNP annotation and gene databases.• Managed clinical study design and sample selection for various studies being carried out in collaboration with various external and internal clinicians.• Worked with database programmer to set up an algorithm that automated efficient intellectual property, biomarkers and PubMed searches based on sequences and text.• Worked with external legal counsel on the identification, filing, and prosecution of various inventions.• Performed the analysis of QPCR data, primer design of various biomarkers for clinical utility. -
Group Leader Research BioinformaticsIncyte Genomics Nov 1995 - Jan 2003Wilmington, Delaware, Us• Managed a bioinformatics group involved with the data mining and usage of novel methods for the discovery of secreted proteins (use and construction of Hidden Markov models), and the analysis of laboratory data from cell based assays.• Served as the technical expert on various research Committees for collaboration with external pharmaceutical partners for discovery of novel protein therapeutics. • Managed and participated in client interactions, client presentations, business development and helped in closing multimillion-dollar deals.• The key bioinformatics scientist charged with the discovery of novel protein therapeutics and antibody targets for use in external collaborations.• Served as technical expert called upon by research groups to support bioinformatics needs by extensive analysis of EST, Genomic, Micro array, SNPs, sub-cellular localization, secondary structure analysis, et cetera, and subsequently generating an integrated in-silico picture of targets.• Managed the overall design, development, and quality control of novel algorithms based on scientific methods and models with emphasis in the field of data-mining of cell surface molecules and high-value drug targets.
Preeti Gupta Lal Ph.D Education Details
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Stanford UniversityOncology And Cancer Biology -
Medical University Of South CarolinaImmunology
Frequently Asked Questions about Preeti Gupta Lal Ph.D
What company does Preeti Gupta Lal Ph.D work for?
Preeti Gupta Lal Ph.D works for Vgenomics - Your Dna Decoder
What is Preeti Gupta Lal Ph.D's role at the current company?
Preeti Gupta Lal Ph.D's current role is Translation Medicine | Companion Diagnostics | Clinical Biomarker | Machine Learning | Big Data | Bioinformatics | Drug Development | Diagnostic Development | CLIA | FDA | Clinical trials |.
What schools did Preeti Gupta Lal Ph.D attend?
Preeti Gupta Lal Ph.D attended Stanford University, Medical University Of South Carolina.
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