Design and synthesis of small molecule RNA-targeted libraries and the QSAR hit follow-up series of RNA-targeted compounds.

Chemical technology process research, pilot scale synthesis and development of industrially viable methods. Managed and actively participated in contract research projects. Provided expert support to customer service, prepared quotations and cost evaluations. Conducted synthetic route scouting, task distribution, and team coordination. Composed product master files, technological SOPs, internal documentation and external reporting.

With Prof. M. Frederick Hawthorne. Cancer Therapy and Imaging. Design and synthesis of catabolism-proof structural modules for incorporation in new pharmaceuticals. DMPK studies of new compounds for the boron-10 neutron capture cancer therapy (BNCT). MS MALDI tissue imaging. Analytical LC/MS control of blood and excrements for animal studies. Isolation and structure elucidation of major metabolites of the lead compounds via high resolution MS/MS methods.

Served on the board of directors of Enamine Ltd. Directed customer service, business development, marketing and the sales team for the North American region. Guided the foundation of the Contract Biology Department at Enamine Ltd., complementing medicinal chemistry with biological HTS, ADME/Tox profiling, and new focused services for drug discovery.

With Prof. Matthew D. Disney. Synthetic modification of aminoglycoside antibiotics. Development of new diversity-oriented synthetic methodologies for obtaining small molecule libraries. Design of microarray assays for high throughput screening. Conjugation of bioactive compounds with fluorescent probes for the detailed studies of binding modes with relevant biological targets.

Group leader on contract projects for synthesis of reference standards and impurities for quality control of drug candidates, active pharmaceutical ingredients, and agrochemicals.

With Prof. Howard E. Zimmerman. Post-doctoral training and experimental research in photochemistry and physical organic chemistry. Research in theoretical aspects of photochemistry utilizing electronic structure exploration.

Process Research