Qing Zhang Email & Phone Number

South San Francisco, California, Us

Global RWD Lead for Lung Driver Mutations Lifecycle Team

South San Francisco, California, Us

Provide Bioinformatics support for Antibody Engineering and Protein Sciences

Tarrytown, New York, Us

Molecular ProfilingLead Oncology molecular profiling support across the pipeline: discovery, PK/PD & tox, translational and clinical• Led team to establish workflow and analysis pipeline for NGS profiling of tumor samples at both RNA and DNA level• Initiated testing of drug efficacy using in vivo models derived from CCLE/CGP tumor cell lines & established computational pipeline to discover predictive responder biomarkers by correlating response with public CCLE/CGP baseline profiling data• Established signature score algorithm enabling pathway/network analysis• Principal Investigator for TCGA data access dbGaP application for Regeneron • Participate in ImmunoOncology Working GroupFounded and led Integrated Genetics Working Group• Mined Loss Of Function genes from 1000 Genome Project for their Gain of Function variations from OMIM• Integrated in-house mouse KO phenotype & RNA-Seq profiling data for extreme phenotype analysis correlating phenotype with expression & variation dataEnabled molecular profiling and phenotype data integration, visualization & search capabilities across companyCoordinate with IT on development of Molecular Profiling project tracking system & Disease target data mining crowd-sourcing system

Formerly Schering-Plough Research InstituteDiscover & develop biomarkers (target engagement, pharmacodynamics & predictive responder), & provide bioinformatics support for oncology programs• 2 biologics (monoclonal antibodies) (including MK3475 aka Keytruda Phase I clinical trial)• 3 small molecules (including MK8353 ERKi in Phase I clinical trial)Contribute to Biomarker & Statistical Analysis Plan in Early Development Plan (EDP), Protocol, & Sample Collection Requirements in Procedural Manual for clinical programs Coordinate genome-wide molecular profiling effort & integrated data analysis for mutation, copy number variation, gene expression, next generation sequencing & proteomicsInitiated collaboration with Animal Health to apply molecular profiling (e.g., Next Generation Sequencing (NGS)) to optimize protein production in engineered cells; Initiated collaboration with BioSimilar to apply molecular profiling to discover & develop responder biomarkersServed as Bioinformatics representative on NTRLC IT WG (New Technology Review & Licensing Committee IT Working Group) to evaluate, recommend and fund new technologies

Kenilworth, New Jersey, Us

Co-led Oncology bioinformatics integration effort during Schering Plough & Merck mergerFounded and co-organized Drug Discovery & Development Symposia on Zetia/Vytorin, Sugammadex, Boceprevir & Telcagpant to educate scientists about R&DServed as Bioinformatics lead on Oncology Signal Transduction & Cell Cycle Lead Finding Teams to manage Target Identification/Validation & Lead Identification portfolio and resources Built genome, transcriptome & proteome model for human, mouse, rat & dog; Integrated sequence, species homologs, functional annotation (e.g. tissue expression profile, protein domains) & internal experimental data; Explored outsourcing Designed & implemented novel algorithms (e.g. species conservation & cyclic peptides) to mine peptide candidates for GPCR ligands or other bioactivity; Developed method integrating protein structure modeling (threading) with evolutionarily conversed residues analysis to assist protein function prediction; Applied species conservation (Ka/Ks) to target prioritizationDeveloped phenotype mapping tool to advance druggable genes (e.g. GPCR, protein kinase, ion channel) to target validation; Identify genes in disease loci across species & prioritize based on gene expression profile and QTL strains cSNPsIntegrated and analyzed data from various animal models (e.g., human, mouse, rat, worm) on various platforms (e.g. microarray, proteomics) for Zetia Mechanism of Action projectRecommended targets for anti-infectives & animal health; Cataloged essential genes in bacterial or fungal pathogens; Provided specificity & broad-spectrum-ness by comparative genomicsStreamlined protein functional annotation pipeline & increased efficiency 10x

Managed a group of 5 scientists as direct reports since 1999Co-managed candidate triage project, automated collection of genomic, function and competitive information for targets pursued at Celera Therapeutics & DiagnosticsManaged Isis collaboration project; Selected genes based on anti-sense phenotypeCollaborated with ClearForest & won KDD (Knowledge Disc. & Data Mining) cup 2002Led team & generated first proof that WGS (whole genome shotgun sequencing) worked for eukaryotesDesigned database schema & developed pipeline for genome mapping & annotationServed as contact for Drosophila gap closure with BDGP (Berkeley Drosophila Genome Project) & Baylor; Represented scientists in customer support team

Phd, Pathology

Summer Program, Pharmacoepidemiology

Ms, Computer Sciences

Artificial Intelligence

Postdoctoral Fellow, Cell Biology & Signal Transduction

Bachelor’S Degree, Biochemistry

High School