(1): Founder of MedKoo Biosciences, a global leading supplier of small molecule medicines. Extensive experiences in design and development, and marketing bioactive small molecule drugs for research use.(2): General: 20+ year biotech/pharmaceutical industry experiences in drug synthesis and small molecule drug discovery; 5 year postdoctoral experiences in organic synthesis/medicinal chemistry. (3) : Medicinal/synthetic chemistry: (a) strong expertise in all areas of modern synthetic organic chemistry and medicinal chemistry, including parallel and combinatorial synthesis, chromatographic purification, and characterization of complicated molecules using state-of-the-art instrumentation; (b) extensive ‘bench” experiences on modern drug discovery, including target/receptor/mechanism-based drug design, hit discovery and lead optimization, SAR development, in vitro evaluation assay, HTS and ADMET, (c) deep and wide knowledge of SAR for anticancer drug candidates.(4): R & D experiences on 3 approved drugs and 3 drug candidates under clinical trial development, and 10+ drug candidates under pre-clinical trial stage. (5). Other “bench research” experiences: pre-formulation and formulation development; bioconjugation chemistry, protein and enzyme assay, analytical method development, biomolecule labeling, synthesis of peptides, carbohydrates, pyrrolic pigments, porphyrins, heterocycles, PEG derivatives, MRI agents, radio labeled molecules.(6). Other scientific skills: familiar with basic aspects of biochemistry, cell/molecular biology, pharmacology, ADMET, assay development, compound profiling, and data analysis; strong skills on scientific information searching; strong presentation and communication skills. Fluent in English and Chinese.(7). Publication records: author or co-author of 10 books, >20 patents plus >100 publications in international reputable journals.
Listed skills include Drug Discovery, Organic Chemistry, Medicinal Chemistry, Chemistry, and 33 others.
