Responsable de projet - Ingénieur en électrophysiologieDéveloppement de projet et tests précliniques de composés pharmaceutiques en neurones sur tranches et en culture Supervisions des étudesAcquisition et analyse de données expérimentales Rapport scientifiques et communication client

In my group we investigate the involvement of astrocytes in neurotransmission regulation regarding memory formation and consolidation processes. Various mechanisms as gliotransmitter release and neurotransmitter uptake enable this neural cell type to influence synaptic information transfer in long-term. We also investigate their involvement in neurodegenerative disorders as epilepsy.

During my Ph.D., I used to work on in vitro hippocampal neuron primary cultures for electrophysiology and diverse molecular biology technics to investigate presynaptic mechanisms of vesicular fusion, evoked neurotransmitter release and synaptic plasticity. In the same period, in collaboration with other neuroscientists, we developed technics and data analysis in order to correlate presynaptic Ca2+ transients events with quantal neurotransmitter release using Ca2+ indicator. I also scrutinized several potential Ca2+-sensors for their functions in exocytosis using knock-out mouse models.

Neurophysiology and new microscopy laboratory (Inserm U603)Study of the astrocyte transporters currents within the somatosensory cortex: Research project on glutamate uptake by astrocytes in cortical layer IVEtude des courants de transporteurs du glutamate au sein des astrocytes de la couche IV du cortex somatosensoriel primaire : Projet de recherche portant sur l'absorption du glutamate par les astrocytes au sein de la couche IV du cortex somatosensoriel

Neurophysiology and new microscopy laboratory (Inserm U603)Study of Kir4.1 potassium channel expression within oligodendrocytes precursors cells during postnatal myelination ETUDE DE L’EXPRESSION DU CANAL POTASSIQUE KIR4.1 DANS LES CELLULES PRECURSEURS D’OLIGODENDROCYTES AU COURS DE LA MYELINISATION POSTNATALE DU CORTEX SOMATOSENSORIEL