Providing expert guidance in areas including chemical processes, laboratory analyses and quality management systems for the chemical, pharmaceutical and environmental industries.

My responsibilities include the leadership of all NMR and MS structure elucidation activities at the 5 Merck research sites (Rahway and Kenilworth, NJ; West Point, PA; Boston, MA, South San Francisco, CA). We also provide support for the Merck Research site in Cambridge MA,for intractable and/or time-critical problems at our manufacturing sites, and with our outsourcing partners overseas.

My responsibilities included the leadership of all chemistry-related NMR activities at the 4 Merck research sites (Rahway and Kenilworth, NJ; West Point, PA; Boston, Ma). We also provide support for intractable and/or time-critical problems at our manufacturing sites and with our outsourcing partners overseas.

My responsibilities included the leadership of all chemistry-related NMR activities at the Merck research sites located in NJ (Rahway and Kenilworth). We also provide support for intractable and/or time-critical problems at our manufacturing sites and with our outsourcing partners overseas.

Highly motivated and successful Project Coordinator/Chemistry Team Leader for various incoming process development projects involving drug candidates in clinical trials with on-site budgets exceeding $1,000,000. -Provide general spectroscopy support and foreign material identification for both process development and manufacturing (Liquids NMR, Raman, NIR, UV, and FT-IR). This support comprises structure verification and chemical shift assignment of 300-500 compounds per year. Also provide final product testing for a 1.8 billion dollar per year drug that utilizes NMR as a primary release test. -Provide expert specialty NMR problem solving support for process development and manufacturing. This role includes low-level impurity isolation and identification, troubleshooting unknowns in commercial processes, and assisting process chemists with identification of intermediates and unknown by-products. -Provide Solid State NMR support for all Roche sites as designated 'Center of Excellence' for polymorph identification and quantitation. -Develop new NMR techniques to expedite small molecule structure elucidation. These methods provide more efficient approaches to both structure identification and stereochemical determination.-Develop, implement, and supervise all Process Analytical Technology (PAT) projects on-site at lab scale, pilot scale, and manufacturing scale (NMR, NIR, Mid-IR, Raman, MS, RI, density, chemometrics, etc.; interface data with automation and plant DCS). Evaluation of at least 20 lab PAT projects and implementation of more than 10 plant applications per year make Roche Carolina the corporation's world-wide leader in PAT. Implementation of PAT projects at our site consistently reflects significant cost savings and a 40% average decrease in cycle times for each step. Implementation of PAT to hazardous chemistry has allowed our site to run processes that can not be safely run at other Roche API sites.

Provided specialty NMR and problem solving support for Medicinal and Natural Products Chemists.-Developed new NMR Techniques to expedite small molecule structure elucidation.-Developed new NMR and chemical approaches for the determination of relative and absolute stereochemistry.-Regularly utilized modern LC techniques coupled with UV, MS, MS-MS, and NMR detection. Our laboratory at Wyeth used Bruker NMR instruments and HP/Agilent LC and MS systems.-Regularly incorporated low-resolution MS using ESI, CI, APCI, and EI ionization into the solution of routine and non-routine structure problems.-Regularly incorporated high-resolution FT-MS and SORI-CAD FT-MS mass spectral data into the solution of routine and non-routine structure problems.-Supervised 3 direct Reports (2 NMR and 1 FT-MS

Explored the application and development of new NMR pulse sequences to real world problems.-Studied the isolation, structure elucidation, and biosynthesis of marine cyanobacterial metabolites under the direction of Dr. William H. Gerwick.-Incorporated a wide breadth of chromatographic techniques and stationary phases into the isolation of structurally challenging and potentially unstable compounds. These techniques included HPLC, GC-MS (chiral and non-chiral), LC-MS, Vacuum Liquid Chromatography (VLC; C18 and Si). In addition, a wide variety of stationary phases such as LH-20, HP-20, Silica Gel, C18, C8, CN, diol, chiral cyclodextrin, and valine-based chiral columns were used as needed to solve particular problems. Isolations ranged from the sub-microgram to gram level.-Studied the isolation, structure elucidation and biosynthesis of both terrestrial and marine Streptomyces sp. secondary metabolites under the direction of Dr. Steven J. Gould and Dr. John R. Carney.-Gained considerable experience and knowledge in the organic synthesis of a wide variety of isotopically labeled precursors for biosynthetic feeding experiments.-Acquired a detailed working knowledge of primary and secondary metabolism pathways.

Studied the isolation, structure elucidation, total synthesis, and structure-activity relationships of biologically active galactolipids from marine cyanobacteria under the direction of Dr. Pamela Seaton.-Gained experience in standard chromatographic techniques and structure elucidation as well as a great deal of familiarity and knowledge of modern synthetic chemistry techniques.