Rachael Barton Email & Phone Number

Tarrytown, New York, United States

Novel Molecules Purification Development Group, Pre-Clinical Manufacturing and Process Development Department

Tarrytown, NY

• Novel Molecules Purification Development Group, Pre-Clinical Manufacturing and Process Development Department
• Led team of five direct reports in mammalian cell culture purifications of research reagents and candidate molecules under consideration for clinically-enabling programs.
• Collaborated with representatives from multiple departments to provide cross-functional assessments for ease of clinically-enabling development for select novel molecules.
• Communicated with Regeneron… Show more Novel Molecules Purification Development Group, Pre-Clinical Manufacturing and Process Development Department
• Communicated with Regeneron researchers and program management on timelines, inventory, and quality characteristics of reagent and candidate productions in support of program-specific objectives and trouble-shooting.
• Served as department representative for one early stage program, with responsibilities including active participation at multi-department meetings, coordination and/or authoring of process development regulatory.

Tarrytown, NY

• Membrane Technologies Purification Development Group, Pre-Clinical Manufacturing and Process Development Department
• Designed commercially-enabling virus retentive filtration and ultrafiltration/diafiltration unit operations for a monoclonal antibody process utilizing Quality by Design principles.
• Developed purification processes for monoclonal antibodies in support of multiple speed-to-clinic programs, with unit operations including but not limited to affinity, anion exchange, and… Show more Membrane.
• Developed purification processes for monoclonal antibodies in support of multiple speed-to-clinic programs, with unit operations including but not limited to affinity, anion exchange, and hydrophobic interaction.
• Supported the development and transfer of clinically- and commercially-enabling purification unit operations through authoring of development reports, issuance of transmittals, review of manufacturing records and model.
• Managed a summer intern in investigations of ImmunoPET conjugation scale-up and process robustness studies.

Bethlehem, PA

• Department of Chemical and Biomolecular Engineering
• Utilized novel biochemical and computational techniques to identify conserved amino acids and motifs that impact homomeric interactions for two transmembrane proteins: plexinA3 and neuropilin-2a.
• Designed and expressed recombinant fusion proteins using an inducible E. coli expression system to assess biochemical characteristics of select receptor domains.
• Developed novel cell-based methods to characterize ligand binding activity… Show more Department of Chemical and Biomolecular Engineering
• Developed novel cell-based methods to characterize ligand binding activity and specificity, and used these methods to determine effects of juxtamembrane mutations on receptor signal transduction.
• Initiated an in vivo zebrafish model in the laboratory to characterize the physiological impacts of mutations to key motifs identified in transmembrane receptors, incorporating core developmental genetics techniques.

Tarrytown, NY

• Cell Culture and Media Development Group, Pre-Clinical Manufacturing and Process Development Department
• Developed a shake flask model for cell growth and antibody production in fed-batch 2L bioreactors to increase throughput in mammalian cell line screenings and media development efforts.
• Supported transfer of the shake flask model of 2L bioreactors to the Protein Expression Sciences Department to facilitate cell line screening efforts.
• Assisted in optimization experiments… Show more Cell Culture and Media Development Group, Pre-Clinical Manufacturing and Process Development Department
• Assisted in optimization experiments examining the effects of media adjustments, temperature, pH, and agitation rate on antibody production in shaker tubes, shake flasks, and 2L bioreactors with teams of two to seven.
• Contributed to beta testing efforts for the Nova Biomedical BioProfile CDV. Show less

West Point, PA

• Viral Vaccines Group
• Developed a flow cytometry cell cycle assay and synchronization procedure for a mammalian cell line in efforts to investigate the cell density effect in adenovirus-infected cultures.
• Created a new media formulation that reduced cellular ammonia production.

West Point, PA

Viral Vaccines GroupModeled cell growth of a mammalian cell line in roller bottles using T-flasks to increase throughput of process optimization experiments.

Doctor Of Philosophy (Ph.D.), Chemical And Biomolecular Engineering, 4.0

Activities and Societies: Chemical Engineering Graduate Association Advisor: Bryan W. Berger Thesis Title: “Understanding the role of.

Bachelor Of Science (B.S.), Chemical And Biomolecular Engineering, 3.68

Activities and Societies: American Institute of Chemical Engineers